Tag: 300-400

Synthesis of Complexes with Abnormal “Protic” N-Heterocyclic Carbenes was written by Jin, Hanpeng;Tan, Tristan Tsai Yuan;Hahn, F. Ekkehardt. And the article was included in Angewandte Chemie, International Edition in 2015.Product Details of 15813-09-9 This article mentions the following:

Neutral 4-iodo-N-ethylimidazole 3 oxidatively adds to [Pt(PPh₃)₄] to give, in the presence of different tetraalkylammonium salts, complexes trans-[4], trans-[5], and trans-[6] containing an anionic C4-bound heterocycle with an unsubstituted ring-nitrogen atom. Complex trans-[4] reacts with the proton source NH₄I under protonation of the ring-nitrogen atom to produce complex trans-[7]I which bears an NH,NR-substituted aNHC ligand. The reaction of trans-[4] with CH₃I yields the complex trans-[8]I which has a classical aNHC ligand with two alkylated ring-nitrogen atoms. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Product Details of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Product Details of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

1,3-Diiodo-5,5-dimethylhydantoin: an efficient reagent for iodination of aromatic compounds was written by Chaikovskii, V. K.;Filimonov, V. D.;Funk, A. A.;Skorokhodov, V. I.;Ogorodnikov, V. D.. And the article was included in Russian Journal of Organic Chemistry in 2007.Name: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

1,3-Diiodo-5,5-dimethylhydantoin (I) in organic solvents successfully iodinates alkylbenzenes, aromatic amines, and Ph ethers. The reactivity of electrophilic iodine is controlled by the acidity of the medium. Superelectrophilic iodine, generated upon dissolution of I in sulfuric acid, readily reacts with electron-deficient arenes at 0 to 20° with formation of the corresponding iodo derivatives in good yields. The structure of electrophilic iodine species generated from I in sulfuric acid is discussed. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Name: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Name: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective and effective iodination of alkyl-substituted benzenes with elemental iodine activated by selectfluor F-TEDA-BF₄ was written by Stavber, Stojan;Kralj, Petra;Zupan, Marko. And the article was included in Synlett in 2002.Reference of 3268-21-1 This article mentions the following:

Selective direct introduction of an I atom into alkyl-substituted benzene derivatives was effectively achieved by reaction of target mols. with elemental I₂ in the presence of 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor F-TEDA-BF₄). The number of I atoms introduced could be modulated by the molar ratio between substrate, I₂ and F-TEDA-BF₄. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Reference of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Reference of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-assisted displacement reaction of nonactivated iodoarenes with arenesulfinates. Convenient alternative synthesis of unsymmetrical diaryl sulfones was written by Suzuki, Hitomi;Abe, Hajime. And the article was included in Tetrahedron Letters in 1995.Reference of 3268-21-1 This article mentions the following:

In the presence of CuI in hot DMF, a variety of functionalized iodoarenes ArI (Ar = Ph, 4-MeC₆H₄, C₆Me₅, 4-PhSC₆H₄, etc.) undergo nucleophilic displacement reaction with sodium arenesulfinates Ar’SO₂Na (Ar’ = Ph, 4-MeC₆H₄) to give the corresponding unsym. diaryl sulfones ArSO₂Ar’ in moderate to good yields. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Reference of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Reference of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photoinduced self-assembly of Pt(II)-linked rings and cages via the photolabilization of a Pt(II)-pyridine bond was written by Yamashita, Ken-ichi;Sato, Kei-ichi;Kawano, Masaki;Fujita, Makoto. And the article was included in New Journal of Chemistry in 2009.Electric Literature of C10H12I2 This article mentions the following:

An inert Pt(II)-pyridine bond is considerably labilized upon UV irradiation On the basis of this phenomenon, kinetically inert Pt(II)-linked coordination rings and cages are formed in high yields from their components by obtaining a kinetically distributed mixture and subsequently equilibrating the mixture into the thermodynamically stable structures upon temporary photolabilization. This method is applicable when the pyridine rings in the ligands are not conjugated with other aromatic rings, in good agreement with DFT calculations that indicate the dependency of the photolability on the π-conjugation of the ligand frameworks. Interruption of π-conjugation either by introducing an methylene linker or by twisting the aromatic rings are effective to accomplish the photoinduced self-assembly. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Electric Literature of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Modular Approach to Arylazo-1,2,3-triazole Photoswitches was written by Tuck, Jeremy R.;Tombari, Robert J.;Yardeny, Noah;Olson, David E.. And the article was included in Organic Letters in 2021.Name: N,N-Diethyl-4-iodobenzamide This article mentions the following:

Azoheteroarenes make up an emerging class of photoswitchable compounds with unique photophys. properties and advantages over traditional azobenzenes. Therefore, methods for synthesizing azoheteroarenes are highly desirable. Here, we utilize azide-alkyne click chem. to access arylazo-1,2,3-triazoles, a previously unexplored class of azoheteroarenes that exhibit high thermal stabilities and near-quant. bidirectional photoconversion. Controlling the catalyst or 1,3-dipole grants access to both regioisomeric arylazotriazoles and arylazoisoxazoles, highlighting the versatility of our approach. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Name: N,N-Diethyl-4-iodobenzamide).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Name: N,N-Diethyl-4-iodobenzamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

General and facile route to isomerically pure tricyclic peptides based on templated tandem CLIPS/CuAAC Cyclizations was written by Richelle, Gaston J. J.;Ori, Sumeet;Hiemstra, Henk;van Maarseveen, Jan H.;Timmerman, Peter. And the article was included in Angewandte Chemie, International Edition in 2018.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

We report a one-pot ligation/cyclization technol. for the rapid and clean conversion of linear peptides into tricyclic peptides that is based on using tetravalent scaffolds containing two benzyl bromide and two alkyne moieties. These react via CLIPS/CuAAC reactions with cysteines and azides in the peptide. Flexibility in the scaffolds is key to the formation of isomerically pure products as the flexible scaffolds T4₁ and T4₂ mostly promote the formation of single isomeric tricycles while the rigid scaffolds T4₃ and T4₄ do not yield clean products. There seems to be no limitation to the number and types of amino acids present as 18 canonical amino acids were successfully implemented. We also observed that azides at the peptide termini and cysteine residues in the center gave better results than compounds with the functional groups placed the other way round. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Three chloro(trifluoromethyl)pyridines as model substrates for regioexhaustive functionalization was written by Cottet, Fabrice;Schlosser, Manfred. And the article was included in European Journal of Organic Chemistry in 2004.Name: 2-Chloro-5-(trifluoromethyl)-4-iodopyridine This article mentions the following:

As a further test of the concept of regioexhaustive functionalization, 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)pyridine were each converted into the three possible carboxylic acids. This was achieved by employing several, but not all of the organometallic “toolbox methods”; transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration, site discriminating deprotonation with lithium N,N-diisopropylamide or lithium 2,2,6,6-tetramethylpiperidide, regio-divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Name: 2-Chloro-5-(trifluoromethyl)-4-iodopyridine).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 2-Chloro-5-(trifluoromethyl)-4-iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro was written by Thames, Joy E.;Waters, Charles D. III;Valle, Coralie;Bassetto, Marcella;Aouadi, Wahiba;Martin, Baptiste;Selisko, Barbara;Falat, Arissa;Coutard, Bruno;Brancale, Andrea;Canard, Bruno;Decroly, Etienne;Seley-Radtke, Katherine L.. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Safety of 4,5-Diiodo-1H-imidazole This article mentions the following:

Flaviviruses, such as Dengue (DENV) and Zika (ZIKV) viruses, represent a severe health burden. There are currently no FDA-approved treatments, and vaccines against most flaviviruses are still lacking. We have developed several flexible analogs (“fleximers”) of the FDA-approved nucleoside Acyclovir that exhibit activity against various RNA viruses, demonstrating their broad-spectrum potential. The current study reports activity against DENV and Yellow Fever Virus (YFV), particularly for compound 1. Studies to elucidate the mechanism of action suggest the flex-analog triphosphates, especially 1-TP, inhibit DENV and ZIKV methyltransferases, and a secondary, albeit weak, effect on the DENV RNA-dependent RNA polymerase was observed at high concentrations The results of these studies are reported herein. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Safety of 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Modulation of π-electron conjugation in oligo(triacetylene) chromophores by incorporation of a central spacer was written by Martin, Rainer E.;Wytko, Jennifer A.;Diederich, Francois;Boudon, Corinne;Gisselbrecht, Jean-Paul;Gross, Maurice. And the article was included in Helvetica Chimica Acta in 1999.Synthetic Route of C10H12I2 This article mentions the following:

A series of trimeric hybrid oligomers was prepared by insertion of different hetero-spacers between two (E)-hex-3-ene-1,5-diyne (E = 1,2-diethynylethene, DEE) moieties, and the optical and electrochem. properties of the resulting π-conjugated materials were compared to those of the DEE dimer and trimer, which formally contain a DEE moiety as homo-spacer. The hetero-spacers were: benzenoid (phenylene, naphthalene, biphenylene, anthracene), π-electron-deficient (pyrazine, pyridine) and π-electron-rich (thiophene, furan) aromatic rings, and trans-Pt(PEt₃)₂. The hybrid oligomers were synthesized using the method of K. Sonogashira et al. (1978), i.e., cross-coupling between mono-deprotected DEE and the appropriately bis-functionalized spacer. UV/VIS data revealed that the majority of the hetero-spacers were less effective than the homo-spacer DEE in facilitating π-electron delocalization along the linearly conjugated oligomeric backbone. With increasing degree of benzenoid aromaticity in the hetero-spacer, the electronic communication between the terminal DEE moieties in the hybrid oligomers was reduced. As a remarkable exception, a large bathochromic shift of the longest-wavelength absorption maximum, which is indicative of enhanced π-electron delocalization, was obtained upon introducing an anthracene-9,10-diyl moiety as hetero-spacer. Electrochem. studies by cyclic and steady-state voltammetry confirmed the limited extent of π-electron delocalization in the majority of the hybrid oligomers. The fluorescence properties of many of the DEE hybrid materials were dramatically enhanced upon incorporation of the heterospacers. The heterocyclic derivatives containing pyridine, pyrazine, or thiophene spacers, resp., displayed a strong fluorescence emission, demonstrating the value of combining repeat units to modulate oligomeric and polymeric properties. The pyridine derivative provided an interesting example of a mol. system, in which both the electronic absorption and emission characteristics can be reversibly switched as a function of pH. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Synthetic Route of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com