Tag: 300-400

Visible-Light-Driven Conversion of Alcohols into Iodide Derivatives with Iodoform was written by Zhao, Yubao;Antonietti, Markus. And the article was included in ChemPhotoChem in 2018.Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene This article mentions the following:

A mild, cost effective, operationally simple and environmentally benign visible-light-driven alc. iodination reaction system for the synthesis of iodoalkanes was developed. In this reaction system, visible light and iodoform were employed as the energy source and iodination reagent, resp. The reaction begins with the homolytic fission of the C-I bond in iodoform induced by visible-light irradiation, produced active radicals. The following steps involved as radical trapping by DMF, nucleophilic substitution, Vilsmeier-type reagent formation, and the final iodination of the alc. The excellent performance of the model reaction in the flow photoreactor demonstrated the potential of this system for practical application. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor was written by Li, Huifang;Ban, Fuqiang;Dalal, Kush;Leblanc, Eric;Frewin, Kate;Ma, Dennis;Adomat, Hans;Rennie, Paul S.;Cherkasov, Artem. And the article was included in Journal of Medicinal Chemistry in 2014.Quality Control of 4,5-Diiodo-1H-imidazole This article mentions the following:

The human androgen receptor (AR) is considered as a master regulator in the development and progression of prostate cancer (PCa). As resistance to clin. used anti-AR drugs remains a major challenge for the treatment of advanced PCa, there is a pressing need for new anti-AR therapeutic avenues. In this study, we identified a binding site on the DNA binding domain (DBD) of the receptor and utilized virtual screening to discover a set of micromolar hits for the target. Through further exploration of the most potent hit (1), a structural analog (6) was identified demonstrating 10-fold improved anti-AR potency. Further optimization resulted in a more potent synthetic analog (25) with anti-AR potency comparable to a newly FDA-approved drug Enzalutamide. Site-directed mutagenesis demonstrated that the developed inhibitors do interact with the intended target site. Importantly, the AR DBD inhibitors could effectively inhibit the growth of Enzalutamide-resistant cells as well as block the transcriptional activity of constitutively active AR splice variants, such as V7. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Quality Control of 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Quality Control of 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Triarylboron-based fluorescent conjugated microporous polymers was written by Liu, Xiaoming;Zhang, Yuwei;Li, He;A, Sigen;Xia, Hong;Mu, Ying. And the article was included in RSC Advances in 2013.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

Novel triarylboron-based conjugated microporous polymers (BCMPs) were successfully synthesized and characterized, which are insoluble in common organic solvents and water, and can keep stable up to 310 °C under a nitrogen atm. According to the nitrogen physisorption isotherms, the Brunauer-Emmett-Teller sp. surface area values for these porous materials vary between 815 and 911 m² g^-1. Two polymer frameworks display good carbon dioxide uptake capacity at 273 K and 1 bar. These materials might find applications in organic electronics and sensing technologies. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Excited-State Structure and Delocalization in Ruthenium(II)-Bipyridine Complexes That Contain Phenyleneethynylene Substituents was written by Wang, Yingsheng;Liu, Shengxia;Pinto, Mauricio R.;Dattelbaum, Dana M.;Schoonover, Jon R.;Schanze, Kirk S.. And the article was included in Journal of Physical Chemistry A in 2001.Category: iodides-buliding-blocks This article mentions the following:

A comprehensive photophys. study was carried out on the two prepared complexes [(bpy)₂Ru(4,4′-PE-bpy)]²⁺ and [(bpy)₂Ru(5,5′-PE-bpy)]²⁺ (44Ru and 55Ru, resp., where bpy = 2,2′-bipyridine and PE = phenyleneethynylene 4-Et₂NCOC₆H₄CC-). The objective of this work is to determine the effect of the phenyleneethynylene substituents on the properties of the metal-to-ligand charge-transfer excited state. The complexes were characterized by using UV-visible absorption, photoluminescence, and UV-visible and IR transient absorption spectroscopy. The results indicate that the MLCT excited state is localized on the PE-substituted bpy ligands. Also, the photophys. data indicate that in the MLCT excited state the excited electron is delocalized into the PE substituents and the manifestations of the electronic delocalization are larger when the substituents are in the 4,4′-positions. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Category: iodides-buliding-blocks).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple method for the synthesis of iodomethylbenzenes was written by Merkushev, E. B.;Sedov, A. M.;Simakhina, N. D.. And the article was included in Zhurnal Organicheskoi Khimii in 1978.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

P-xylene, mesitylene, durene and C₆Me₅H were treated with iodine, HNO₃ and H₂SO₄ in HOAc to give 87% 2,5-Me₂C₆H₃I and 85% 2,5-Me₂C₆H₂I₂-1,4, 88% 2,4,6-Me₃C₆H₂I, 80% 2,4,6-Me₃C₆HI₂-1,3 and 63% 1,3,5-Me₃C₆I₃, 100% 2,3,5,6-Me₄C₆HI and 88% 1,4-I₂C₆Me₄, and 87% C₆Me₅I, resp., depending on the temperature and amount of HNO₃ and H₂SO₄ used. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Probing hydrogen bonding to bound dioxygen in synthetic models for heme proteins: the importance of precise geometry was written by Dube, Henry;Kasumaj, Besnik;Calle, Carlos;Felber, Beatrice;Saito, Makoto;Jeschke, Gunnar;Diederich, Francois. And the article was included in Chemistry – A European Journal in 2009.HPLC of Formula: 15813-09-9 This article mentions the following:

Distal hydrogen bonding in natural dioxygen binding proteins is crucial for the discrimination between different potential ligands such as O₂ or CO. In the present study, we probe the chem. requirements for proper distal hydrogen bonding in a series of synthetic model compounds for dioxygen-binding heme proteins. The model compounds 1-Co to 7-Co bear different distal residues. The hydrogen bonding in their corresponding dioxygen adducts is directly measured by pulse EPR spectroscopy. The geometrical requirements for this interaction to take place were found to be narrow and very specific. Only two model complexes, 1-Co and 7-Co, form a hydrogen bond to bound dioxygen, which was characterized in terms of geometry and nature of the bond. The geometry and dipolar nature of this interaction in 1-Co-O₂ is more similar to the one in natural cobalt myoglobin (Co-Mb), making 1-Co the best model compound in the entire series. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9HPLC of Formula: 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.HPLC of Formula: 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Oxidative displacement of halogen from alkyl halides by phenyliodine(III) dicarboxylates was written by Gallos, John;Varvoglis, Anastasios. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1983.Reference of 3268-21-1 This article mentions the following:

The reaction of alkyl iodides with aryliodine(III) dicarboxylates gave mainly esters derived through substitution of iodine by an acyloxy group, together with, in some cases, α-iodoalkyl esters. E.g., reaction of PhI(O₂CCF₃)₂ with Me₂CHI in EtOH-free CHCl₃ in the dark at room temperature for 2-8 h gave F₃CCO₂CHMe₂, quant. Reactive bromides and chlorides reacted similarly. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Reference of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Reference of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Thiophene-expanded guanosine analogues of gemcitabine was written by Chen, Zhe;Ku, Therese C.;Seley-Radtke, Katherine L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Recommanded Product: 4,5-Diiodo-1H-imidazole This article mentions the following:

The chemotherapeutic drug Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine, has long been the standard of care for a number of cancers. Gemcitabine’s chemotherapeutic properties stem from its 2′,2′-difluoro-2′-deoxyribose sugar, which mimics the natural nucleoside, but also disrupts nucleic acid synthesis, leading to cell death. As a result, numerous analogs have been prepared to further explore the biol. implications for this structural modification. In that regard, a thieno-expanded guanosine analog was of interest due to biol. activity previously observed for the tricyclic heterobase scaffold. Several analogs were prepared, including the McGuigan ProTide, however the parent nucleoside exhibited the best chemotherapeutic activity, specifically against breast cancer cell lines (89.53% growth inhibition). In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Convergent Synthesis of Immune Inhibitor IMMH002 was written by Chen, Si;Shi, Zeyu;Xiao, Qiong;Yin, Dali. And the article was included in Synthesis in 2021.Computed Properties of C8H8BrI This article mentions the following:

A convergent synthesis of IMMH002 in 36% overall yield starting from bromobenzene was described with a key Suzuki-Miyaura cross-coupling reaction used to provide a crucial intermediate. The route does not require column chromatog. and solves the most intractable quality problem caused by a homolog byproduct in the original linear synthesis. Furthermore, reducing the use of Lewis acid mediated reactions improves the environmental impact of the synthesis and reduces overall waste. The new route described herein was more efficient, convenient, reliable, and economically more viable when compared to the previously reported linear route. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Computed Properties of C8H8BrI).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Computed Properties of C8H8BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Study on synthesis of 2-chloro-5-trifluoromethyl pyridine-4-yl-boronic acid was written by Liu, Guoquan;Wang, Shanshan;Liang, Jiudi;Li, Qiuwu;Han, Jianrong. And the article was included in Hebei Keji Daxue Xuebao in 2014.Formula: C6H2ClF3IN This article mentions the following:

2-Chloro-5-trifluoromethyl pyridine-4-yl-boronic acid was prepared with 2-chloro-4-iodo-5-trifluoromethyl pyridine as the raw material through reaction with Bu lithium reagent. Several reaction conditions of the synthesis process were studied through the experiment The purity and structure of the products were characterized by HPLC, FTIR and ¹H NMR. Exptl. result shows that when the temperature is -70°C, the reaction time is 2h, the molar ratio of n(C₆H₂ClF₃IN):n(C₁₂H₂₇BO₃):n(C₄H₉Li)is=1.00:1.20:1.20, and the pH is 9.0, the yield of 2-chloro-5-trifluoromethyl pyridine-4-yl-boronic acid reaches 83.10%, and its purity is up to 98.65%. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Formula: C6H2ClF3IN).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Formula: C6H2ClF3IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com