Tag: 300-400

The author of 《Methyl, Trifluoromethyl, and Methoxycarbonyl-Introduction to the Fifth Position on the Pyridine Ring of Chloronicotinyl Insecticide Imidacloprid》 were Kagabu, Shinzo. And the article was published in Synthetic Communications in 2006. Name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine The author mentioned the following in the article:

Imidacloprid is the first (chloro)nicotine insecticide and is currently the largest-selling insecticide worldwide. As a project to find its variants of different insecticidal spectra, derivatives substituted with Me, trifluoromethyl, and methoxycarbonyl at the fifth position on the pyridine ring of imidacloprid were prepared In the experiment, the researchers used many compounds, for example, 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7Name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine)

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Liu, Zhenwei; Luan, Nannan; Shen, Linhua; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie. Application of 301673-14-3. The article was titled 《Palladium-Catalyzed Hiyama Cross-Couplings of Arylsilanes with 3-Iodoazetidine: Synthesis of 3-Arylazetidines》. The information in the text is summarized as follows:

The first palladium-catalyzed Hiyama cross-coupling reactions of arylsilanes with 3-iodoazetidine were described. The protocol provides a convenient access to a variety of useful 3-arylazetidines which are of great interest in pharmaceutical laboratories in moderate to good yields (30%-88%). In addition, this strategy has the advantage of easy operation and mild reaction conditions. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Chen, Bo; Yu, Kai; Wu, Xiao-Feng published an article in Organic & Biomolecular Chemistry. The title of the article was 《Visible-light-induced defluorinative carbonylative coupling of alkyl iodides with α-trifluoromethyl substituted styrenes》.Product Details of 301673-14-3 The author mentioned the following in the article:

A visible-light-mediated defluorinative carbonylative cross-coupling of alkyl iodides RI (R = Me, cyclopentyl, N-Boc azetidin-3-yl, etc.) with α-trifluoromethyl styrenes R1C(=CH2)CF3 (R1 = 4-benzyloxyphenyl, 3-methylphenyl, 2-naphthyl, etc.) has been developed. The reaction occurs at room temperature under blue light irradiation, and various gem-difluoroalkenes R1C(CH2C(O)R)=CF2 were obtained in moderate to good yields. Synthetic transformations of the obtained product were performed as well. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Product Details of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Yan, Songlin; Yu, Weijie; Zhang, Jianye; Fan, Hongmei; Lu, Zhifeng; Zhang, Zhenming; Wang, Tao published an article in Journal of Organic Chemistry. The title of the article was 《Access to gem-Difluoroalkenes via Organic Photoredox-Catalyzed gem-Difluoroallylation of Alkyl Iodides》.Formula: C10H18INO2 The author mentioned the following in the article:

An organic photoredox-catalyzed gem-difluoroallylation of α-trifluoromethyl alkenes CH2=CR(CF3) (R = Br, 4-bromophenyl, thiophen-3-yl, benzodioxol-5-yl, etc.) and 4-(trifluoromethyl)-1,2-dihydronaphthalene with alkyl iodides R1I (R1 = cyclohexyl, oxetan-3-yl, N-boc piperidin-4-yl, etc.) via C-F bond cleavage for the synthesis of gem-difluoroalkene derivatives RC(CH2R1)=CF2 and I is reported. This transition-metal-free transformation utilized a readily available organic dye 4CzIPN as the sole photocatalyst and employed a common chem. N,N,N’,N’-tetramethylethylenediamine as the radical activator of alkyl iodides via halogen-atom transfer. In addition, a variety of iodides, including primary, secondary, and tertiary alkyl iodides, were tolerated and provided good to high yields.tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Formula: C10H18INO2) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Formula: C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Zhen; Koenigs, Rene M. published their research in Chemistry – A European Journal in 2021. The article was titled 《Photoinduced Palladium-Catalyzed Dicarbofunctionalization of Terminal Alkynes》.Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate The article contains the following contents:

Herein, a conceptually distinct approach was developed that allowed for the dicarbofunctionalization of alkynes at room temperature using simple, bench-stable alkyl iodides and a second mol. of alkyne as coupling partner. Specifically, the photochem. activation of palladium complexes enabled this strategic dicarbofunctionalization via addition of alkyl radicals from secondary and tertiary alkyl iodides and formation of an intermediate palladium vinyl complex that could undergo subsequent Sonogashira reaction with a second alkyne mol. This alkylation-alkynylation sequence allowed the one-step synthesis of 1,3-enynes including heteroarenes and biol. active compounds with high efficiency without exogenous photosensitizers or oxidants and now opens up pathways towards cascade reactions via photochem. palladium catalysis. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3》 was written by Li, Zhihong; Wang, Xianghong; Eksterowicz, John; Gribble, Michael W.; Alba, Grace Q.; Ayres, Merrill; Carlson, Timothy J.; Chen, Ada; Chen, Xiaoqi; Cho, Robert; Connors, Richard V.; DeGraffenreid, Michael; Deignan, Jeffrey T.; Duquette, Jason; Fan, Pingchen; Fisher, Benjamin; Fu, Jiasheng; Huard, Justin N.; Kaizerman, Jacob; Keegan, Kathleen S.; Li, Cong; Li, Kexue; Li, Yunxiao; Liang, Lingming; Liu, Wen; Lively, Sarah E.; Lo, Mei-Chu; Ma, Ji; McMinn, Dustin L.; Mihalic, Jeffrey T.; Modi, Kriti; Ngo, Rachel; Pattabiraman, Kanaka; Piper, Derek E.; Queva, Christophe; Ragains, Mark L.; Suchomel, Julia; Thibault, Steve; Walker, Nigel; Wang, Xiaodong; Wang, Zhulun; Wanska, Malgorzata; Wehn, Paul M.; Weidner, Margaret F.; Zhang, Alex J.; Zhao, Xiaoning; Kamb, Alexander; Wickramasinghe, Dineli; Dai, Kang; McGee, Lawrence R.; Medina, Julio C.. Recommanded Product: 3-Bromo-2-fluoro-4-iodopyridine And the article was included in Journal of Medicinal Chemistry on April 24 ,2014. The article conveys some information:

The authors describe the structural optimization of a lead compound that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR anal., using cell-based assays, led to the discovery of AMG 925 (I), a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date. Compound I inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb+) and U937 (FLT3WT) and induced cell death in MOLM13 (FLT3ITD) and even in MOLM13 (FLT3ITD, D835Y), which exhibits resistance to a number of FLT3 inhibitors currently under clin. development. At well-tolerated doses, compound I leads to significant growth inhibition of MOLM13 xenografts in nude mice, and the activity correlates with inhibition of STAT5 and Rb phosphorylation.3-Bromo-2-fluoro-4-iodopyridine(cas: 884494-52-4Recommanded Product: 3-Bromo-2-fluoro-4-iodopyridine) was used in this study.

3-Bromo-2-fluoro-4-iodopyridine(cas: 884494-52-4) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 3-Bromo-2-fluoro-4-iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Haoxiang; Liang, Mengze; Zhang, Xiao; He, Meng-Ke; Yang, Chao; Guo, Lin; Xia, Wujiong published an article in Organic Chemistry Frontiers. The title of the article was 《Electrochemical synthesis of functionalized gem-difluoroalkenes with diverse alkyl sources via a defluorinative alkylation process》.Application of 301673-14-3 The author mentioned the following in the article:

An electrochem. defluorinative alkylation protocol of α-trifluoromethyl alkenes was described. This reaction enabled the preparation of functionalized gem-difluoroalkenes F2C=C(R)CH2R1 [R = 4-MeC6H4, 4-MeOC6H4, 2-naphthyl, etc.; R1 = cyclohexyl, tetrahydropyran-4-yl, Bn, etc.] with the use of diverse alkyl sources including organohalides, N-hydroxyphthalimide (NHP) esters and Katritzky salts. This method exhibited lots of synthetic advantages including mild conditions, simple operation, and convenience of amplification, and provides a new route for the synthesis of gem-difluoroalkenes. In the experimental materials used by the author, we found tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Rio-Rodriguez, Roberto del; Fragoso-Jarillo, Lorena; Garrido-Castro, Alberto F.; Maestro, M. Carmen; Fernandez-Salas, Jose A.; Aleman, Jose published an article in Chemical Science. The title of the article was 《General electrochemical Minisci alkylation of N-heteroarenes with alkyl halides》.Application of 301673-14-3 The author mentioned the following in the article:

A general, facile and environmentally friendly Minisci-type alkylation of N-heteroarenes under simple and straightforward electrochem. conditions using widely available alkyl halides as radical precursors was reported. Primary, secondary and tertiary alkyl radicals were efficiently generated and coupled with a large variety of N-heteroarenes. The method presented a very high functional group tolerance, including various heterocyclic-based natural products, which highlighted the robustness of the method. This applicability was further proved in the synthesis of various interesting biol. valuable building blocks. In addition, a mechanism based on different proofs and pieces of electrochem. evidence was proposed. The results came from multiple reactions, including the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ)》 were Yue, Eddy W.; Li, Yun-Long; Douty, Brent; He, Chunhong; Mei, Song; Wayland, Brian; Maduskuie, Thomas; Falahatpisheh, Nikoo; Sparks, Richard B.; Polam, Padmaja; Zhu, Wenyu; Glenn, Joseph; Feng, Hao; Zhang, Ke; Li, Yanlong; He, Xin; Katiyar, Kamna; Covington, Maryanne; Feldman, Patricia; Shin, Niu; Wang, Kathy He; Diamond, Sharon; Li, Yu; Koblish, Holly K.; Hall, Leslie; Scherle, Peggy; Yeleswaram, Swamy; Xue, Chu-Biao; Metcalf, Brian; Combs, Andrew P.; Yao, Wenqing. And the article was published in ACS Medicinal Chemistry Letters in 2019. Synthetic Route of C10H18INO2 The author mentioned the following in the article:

A medicinal chem. effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3Kδ) led to the discovery of clin. candidate INCB050465 (20, parsaclisib). The unique structure of 20 contains a pyrazolopyrimidine hinge-binder in place of a purine motif that is present in other PI3Kδ inhibitors, such as idelalisib (1), duvelisib (2), and INCB040093 (3, dezapelisib). Parsaclisib (20) is a potent and highly selective inhibitor of PI3Kδ with drug-like ADME properties that exhibited an excellent in vivo profile as demonstrated through pharmacokinetic studies in rats, dogs, and monkeys and through pharmacodynamic and efficacy studies in a mouse Pfeiffer xenograft model. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Synthetic Route of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Synthetic Route of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

de Jesus Cortez, Felipe; Nguyen, Phuong; Truillet, Charles; Tian, Boxue; Kuchenbecker, Kristopher M.; Evans, Michael J.; Webb, Paul; Jacobson, Matthew P.; Fletterick, Robert J.; England, Pamela M. published their research in ACS Chemical Biology on December 15 ,2017. The article was titled 《Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen》.SDS of cas: 887707-25-7 The article contains the following contents:

Resistance to clin. antiandrogens has plagued the evolution of effective therapeutics for advanced prostate cancer. As with the first-line therapeutic bicalutamide (Casodex), resistance to newer antiandrogens (enzalutamide, ARN-509) develops quickly in patients, despite the fact that these drugs have ∼10-fold better affinity for androgen receptor than bicalutamide. Improving affinity alone is often not sufficient to prevent resistance and alternative strategies are needed to improve antiandrogen efficacy. Covalent and reversible covalent drugs are being used to thwart drug resistance in other contexts, and activated aryl nitriles are among the moieties being exploited for this purpose. The authors capitalized on the presence of an aryl nitrile in bicalutamide, and the existence of a native cysteine residue (Cys784) in the androgen receptor ligand binding pocket, to develop 5N-bicalutamide I, a cysteine-reactive antiandrogen. I exhibits a 150-fold improvement in Ki and 20-fold improvement in IC50 over the parent compound The authors attribute the marked improvement in affinity and activity to the formation of a covalent adduct with Cys784, a residue that is not among the more than 160 androgen receptor point mutations associated with prostate cancer. Increasing the residence time of bound antiandrogen via formation of a covalent adduct may forestall the drug resistance seen with current clin. antiandrogens. After reading the article, we found that the author used 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7SDS of cas: 887707-25-7)

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 887707-25-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com