Tag: 300-400

Jin, Youxiang; Wen, Hao; Yang, Feiyan; Ding, Decai; Wang, Chuan published their research in ACS Catalysis in 2021. The article was titled 《Synthesis of Multisubstituted Allenes via Nickel-Catalyzed Cross-Electrophile Coupling》.Product Details of 301673-14-3 The article contains the following contents:

In this study, the successful application of a cross-electrophile strategy in the synthesis of multisubstituted allenes ArC(R1)=C=C(R2)R3 [Ar = thiophen-2-yl, 4-methoxyphenyl, 4-chlorophenyl, etc.; R1 = cyclohexyl, n-Bu, 2-phenylethyl, etc.; R2 = H, Me; R3 = Me, 4-methoxyphenyl, n-pentyl, n-Pr, t-Bu; R2R3 = -(CH2)4-] was reported. Under the catalysis of nickel, reductive cross-coupling between propargyl carbonates ArCCC(OBoc)(R2)R3 and organoiodides R1I provides an entry to prepare tri- or tetrasubstituted allenes without employing any pregenerated organometallics. Furthermore, propargyl carbonates also prove to be suitable allenylating agents in nickel-catalyzed asym. reductive aryl-allenylation of aryl-iodide-tethered unactivated alkenes 2-I-4-R4-5-R5C6H2XCH2C(=CHC2)R6 [R4 = H, Cl, t-Bu; R5 = H, Me, OMe; R4R5 = -OCH2O-; R6 = 2-methoxypheny, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.], furnishing a variety of chiral benzene-fused cyclic compounds I bearing a quaternary allenyl-substituted stereogenic center in a highly enantioselective manner. After reading the article, we found that the author used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Product Details of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Product Details of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cottet, Fabrice; Schlosser, Manfred published their research in Tetrahedron on December 13 ,2004. The article was titled 《Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids》.Recommanded Product: 823221-97-2 The article contains the following contents:

Although there are many conceivable ways to functionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only 2-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid from this precursor and 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl)pyridine into only the 4- and 6-carboxylic acids and to make the 3-carboxylic acid from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. The experimental process involved the reaction of 3-Bromo-5-chloro-2-iodopyridine(cas: 823221-97-2Recommanded Product: 823221-97-2)

3-Bromo-5-chloro-2-iodopyridine(cas: 823221-97-2) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 823221-97-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jia, Xiangqing; Zhang, Ziyan; Gevorgyan, Vladimir published their research in ACS Catalysis in 2021. The article was titled 《Three-Component Visible-Light-Induced Palladium-Catalyzed 1,2-Alkyl Carbamoylation/Cyanation of Alkenes》.HPLC of Formula: 301673-14-3 The article contains the following contents:

A mild visible-light-induced Pd-catalyzed one-pot three-component alkyl-carbamoylation and cyanation of alkenes was developed. This general transformation, which proceeded via the in situ formation of a reactive ketenimine intermediate, allowed for a rapid construction of a broad range of valuable amides I [Ar = Ph, 3-MeC6H4, 4-MeOC6H4, etc.; R1 = n-Bu, i-Bu, 2,2-dimethylpropyl, etc.; R2 = t-Bu, 1-adamantyl, 1,1,3,3-tetramethylbutyl] and nitriles II [Ar1 = Ph, 4-FC6H4, 4-ClC6H4, 4-MeOC6H4, (6-methoxy-3-pyridyl); R3 = n-Bu, cyclohexyl, 2,2-dimethylpropyl, trimethylsilylmethyl, phenethyl] from readily available alkenes, alkyl iodides, and isocyanides. An efficient synthesis of tetrazole and amidine via this approach was also demonstrated. In addition to this study using tert-Butyl 4-iodopiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3HPLC of Formula: 301673-14-3) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.HPLC of Formula: 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides》 was published in Organic Letters in 2020. These research results belong to Huang, Wenyi; Wang, Yun; Weng, Yangyang; Shrestha, Mohini; Qu, Jingping; Chen, Yifeng. Name: tert-Butyl 4-iodopiperidine-1-carboxylate The article mentions the following:

Herein, disclosed a Ni-catalyzed formal aminocarbonylation of primary and secondary unactivated aliphatic iodides with isocyanides to afford alkyl amide, e.g., I, which proceeded via the selective monomigratory insertion of isocyanides with alkyl iodides, subsequent β-hydride elimination, and hydrolysis process. The reaction featured wide functional group tolerance under mild conditions. Addnl., the selective, one-pot hydrolysis of reaction mixture under acid conditions allowed for expedient synthesis of the corresponding alkyl carboxylic acid. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Name: tert-Butyl 4-iodopiperidine-1-carboxylate)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Name: tert-Butyl 4-iodopiperidine-1-carboxylate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic Letters included an article by Chen, Yanchi; Su, Lei; Gong, Hegui. Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate. The article was titled 《Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO》. The information in the text is summarized as follows:

This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Forni, Jose A.; Gandhi, Vir H.; Polyzos, Anastasios published an article in ACS Catalysis. The title of the article was 《Carbonylative Hydroacylation of Styrenes with Alkyl Halides by Multiphoton Tandem Photoredox Catalysis in Flow》.Related Products of 301673-14-3 The author mentioned the following in the article:

The photocatalytic carbonylative hydroacylation of styrenes (R1)R2C=CH2 (R1 = H, Ph, Me, Et; R2 = Ph, naphthalen-2-yl, pyridin-2-yl, thiophen-2-yl, etc.) with inactivated alkyl halides RX (R = Cyclohexyl, cyclopentyl, n-Bu, i-Pr, etc.; X = Br, I) was reported. This protocol unifies the visible-light multiphoton catalytic cycle of [Ir(ppy)2(dtb-bpy)]+ with flow chem. to engage energy-demanding alkyl bromides and iodides at moderate pressures of carbon monoxide. The mild and practical methodol. was employed to prepare a diverse array of 43 unsym. dialkyl ketones RC(O)CH2CH(R1)R2 from primary, secondary, and tertiary inactivated alkyl halides. The application of flow chem. technol. to achieve spatially resolved chemoselectivity and broad functional group tolerance for the mild generation of functionalized C(sp3)-rich ketone products was demonstrated. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Related Products of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Related Products of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2018,Hofmayer, Maximilian S.; Hammann, Jeffrey M.; Cahiez, Gerard; Knochel, Paul published 《Iron-Catalyzed C(sp2)-C(sp3) Cross-Coupling Reactions of Di(hetero)arylmanganese Reagents and Primary and Secondary Alkyl Halides》.Synlett published the findings.SDS of cas: 301673-14-3 The information in the text is summarized as follows:

An iron-catalyzed cross-coupling between di(hetero)arylmanganese reagents and primary and secondary alkyl halides is reported. No rearrangement of secondary alkyl halides to unbranched products was observed in these C-C bond-forming reactions. In addition to this study using tert-Butyl 4-iodopiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3SDS of cas: 301673-14-3) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.SDS of cas: 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2016 ,《Reaction of Alkyl Halides with Rongalite: One-Pot and Telescoped Syntheses of Aliphatic Sulfonamides, Sulfonyl Fluorides, and Unsymmetrical Sulfones》 was published in Organic Letters. The article was written by Shavnya, Andre; Coffey, Steven B.; Hesp, Kevin D.; Ross, Stuart C.; Tsai, Andy S.. The article contains the following contents:

An efficient methodol. has been developed for the one-pot or telescoped synthesis of aliphatic sulfonamides, sulfonyl fluorides, and unsym. sulfones on the basis of interrupted alkylation of sodium hydroxymethylsulfinate (rongalite) with alkyl halides. The protocols are conducted under mild conditions, use inexpensive and shelf-stable reagents, and are not sensitive to air/moisture. These conditions can be applied in rapid parallel chem. synthesis, which was demonstrated by the preparation of a small sulfonamide library based on the core structure of the anticoagulant drug Tirofiban. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Category: iodides-buliding-blocks)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Ren, Xiaoxiao; Gao, Xing; Min, Qiao-Qiao; Zhang, Shu; Zhang, Xingang published an article in Chemical Science. The title of the article was 《(Fluoro)alkylation of alkenes promoted by photolysis of alkylzirconocenes》.SDS of cas: 301673-14-3 The author mentioned the following in the article:

An unprecedented example of alkylzirconocenes Cp2ZrCl(CH2)2R (R = Bn, dimethyl(phenyl)silyl, trimethylsilyl, etc.) promoted difluoroalkylation of alkyl- and silyl-alkenes RCH=CH2 with a variety of unactivated difluoroalkyl iodides and bromides R1C(F2)X (R1 = [(ethanesulfonyl)oxy]methyl, (morpholin-4-yl)carbonyl, 3-[(4-chlorophenyl)carbonyloxy]propyl, etc.; X = I, Br) under the irradiation of visible light without a catalyst. The resulting difluoroalkylated compounds RC(F2)R1 can serve as versatile synthons in organic synthesis. The reaction can also be applied to activated difluoroalkyl, trifluoromethyl, perfluoroalkyl, monofluoroalkyl, and nonfluorinated alkyl halides, providing a general method to controllably access fluorinated compounds Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway induced by a Zr(III) species is involved in the reaction, in which the Zr(III) species is generated by the photolysis of alkylzirconocene with blue light. In the experiment, the researchers used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3SDS of cas: 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.SDS of cas: 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Mingjun; Yu, Mo; Wang, Ziwen; Liu, Yuxiu; Wang, Qingmin published an article in 2022. The article was titled 《Rapid Access to Aliphatic Sulfonamides》, and you may find the article in Organic Letters.Formula: C10H18INO2 The information in the text is summarized as follows:

Herein, a mild, rapid, straightforward method for visible-light-mediated sulfonamide ethylation to afford a diverse array of compounds with C(sp3)-sulfonamide skeletons RS(O)2N(R1)R2 (R = 4-phenylbutyl, 3,3-dimethylbutyl, 2-cyclobutylethyl, 4-(pyridin-2-yl)butyl, etc.; R1 = H, Ph, 2-oxooxolan-3-yl, benzyl, etc.; R2 = H, Me, phenyl) was reported. The method relies on inexpensive, abundant, com. available primary, secondary, and tertiary alkyl carboxylic acids I (R3 = 2-phenylethyl, 2,2-diphenylethyl, 2-(pyridin-3-yl)ethyl, pentyl, etc.) and alkyl iodides R4I (R4 = 2-cyclohexylethyl, pentyl, 4-(trimethylsilyl)butyl, hept-6-yn-1-yl, etc.) as substrates. The method has a broad substrate scope and potential utility for late-stage functionalization of natural products and synthetic medicines and can be expected to facilitate rapid structural diversification of bioactive mols. In addition to this study using tert-Butyl 4-iodopiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Formula: C10H18INO2) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Formula: C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com