Tag: 300-400

On July 15, 2022, Nguyen, Viet D.; Trevino, Ramon; Greco, Samuel G.; Arman, Hadi D.; Larionov, Oleg V. published an article.HPLC of Formula: 1287221-36-6 The title of the article was Tricomponent Decarboxysulfonylative Cross-coupling Facilitates Direct Construction of Aryl Sulfones and Reveals a Mechanistic Dualism in the Acridine/Copper Photocatalytic System. And the article contained the following:

A dual catalytic process that enabled the previously inaccessible, broad-scope, direct conversion of carboxylic acids to aromatic sulfones-centrally important carbonyl group bioisosteric replacements and synthetic intermediates-by a tricomponent decarboxysulfonylative cross-coupling with aryl halides was reported. Detailed mechanistic and computational studies revealed the roles of the copper catalysts, bases and halide anions in channeling the acridine/copper system via a distinct dual catalytic manifold. In contrast to the halide-free decarboxylative conjugate addition that involved cooperative dual catalysis via low-valent copper species, the halide counteranions divert the decarboxysulfonylative cross-coupling with aryl halides through a two-phase, orthogonal relay catalytic manifold, comprising a kinetically coupled (via antithetical inhibitory and activating roles of the base in the two catalytic cycles), mechanistically discrete sequence of a photoinduced, acridine-catalyzed decarboxylative process and a thermal copper-catalyzed arylative coupling. The study underscores the importance of non-innocent roles of counteranions and key redox steps at the interface of catalytic cycles for enabling previously inaccessible dual catalytic transformations. The experimental process involved the reaction of 4-Iodophenylboronic acid MIDA ester(cas: 1287221-36-6).HPLC of Formula: 1287221-36-6

The Article related to carboxylic acid aryl halide potassium metabisulfite acridine copper catalyst, aromatic halide carboxylic acid dabso acridine copper catalyst, aryl sulfone preparation tricomponent decarboxysulfonylative cross coupling reaction and other aspects.HPLC of Formula: 1287221-36-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yoshida, Suguru; Shimomori, Ken; Kim, Youngchan; Hosoya, Takamitsu published an article in 2016, the title of the article was Single C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group.Quality Control of 5-Bromo-2-iodobenzotrifluoride And the article contains the following content:

The transformation of a single C-F bond of trifluoromethylarenes bearing a hydrosilyl group at the ortho position was achieved. The activation of the hydrosilyl group with a trityl cation in the presence of nucleophiles allowed for selective C-F bond functionalization, for example, by allylation, carboxylation, or chlorination. Further derivatization of the resulting fluorosilylarenes afforded various aromatic difluoromethylene compounds The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

The Article related to silylbenzotrifluoride preparation defluorinative monoallylation allyltrimethylsilane trityl cation, fluorobutenyl fluorosilylarene preparation, c−f activation, allylation, fluorine, silanes, trityl cation and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On December 31, 1982, Bolton, Roger; Moore, Clive; Sandall, John P. B. published an article.Computed Properties of 364-12-5 The title of the article was Nucleophilic displacement in polyhaloaromatic compounds. Part 11. Kinetics of protiodeiodination of iodoarenes in dimethyl sulfoxide-methanol. And the article contained the following:

The kinetics were determined of the MeO–induced protiodeiodination of 15 polychloroiodobenzenes and 6 of their Br- or CF3-substituted analogs in 9:1 (volume) DMSO-MeOH at 323.2 K. The true reagent is the DMSO anion. The reaction rates in some cases approached the diffusion-controlled process. Cl and CF3 substituents promote the reaction in the order ortho > meta > para and ortho > para > meta, resp. Protiodeiodinaton is promoted by o-NO2 groups, but the p-NO2 group encourages methoxydeiodination. Unlike polychloroiodobenzenes, polychlorobenzenes underwent methoxydechlorination. A mechanism involving nucleophilic attack by a carbanion was proposed. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Computed Properties of 364-12-5

The Article related to aryl iodide protiodeiodination kinetics, substituent effect protiodeiodination iodoarene, chlorobenzene methoxydechlorination kinetics, iodochlorobenzene substitution methanol kinetics and other aspects.Computed Properties of 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On September 14, 2017, Janetka, James W.; Mydock-McGrane, Laurel published a patent.Quality Control of 5-Bromo-2-iodobenzotrifluoride The title of the patent was Preparation of C-glycoside compounds useful for treating urinary tract infection. And the patent contained the following:

The present invention relates to mannosides I, wherein Ar is aryl, heteroaryl; Y1 and Y2 are independently H, hydroxyl, alkoxy, amino; were prepared and are useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection, bacterial infection, Crohn’s disease, and inflammatory bowel disease. Thus, glycoside II was prepared and tested for its hemagglutination (EC>90 = 0.006 μM) inhibition and as FimH inhibitor. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

The Article related to antibacterial antagonist hemagglutination urinary tract infection glycoside preparation mannoside, alkyne azide cycloaddition suzuki coupling fimh inhibitor human antibiotic, triazole click preparation c glycoside urinary tract infection and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On January 31, 2022, Shen, Guodong; Lu, Qichao; Wang, Zeyou; Sun, Weiwei; Zhang, Yalin; Huang, Xianqiang; Sun, Manman; Wang, Zhiming published an article.Product Details of 1012882-90-4 The title of the article was Environmentally Friendly and Recyclable CuCl2 -Mediated C-S Bond Coupling Strategy Using DMEDA as Ligand, Base and Solvent. And the article contained the following:

An environment-friendly, recyclable and economic strategy was developed to synthesize diaryl chalcogenides by the CuCl2-catalyzed C-S bond-formation reaction via iodobenzenes and benzenethiols/1,2-diphenyldisulfanes using N,N’-dimethylethane-1,2-diamine (DMEDA) as ligand, base and solvent. For these reactions, especially the reactions of diiodobenzenes and aminobenzenethiols/disulfanediyldianilines, a range of substrates were compatible and gave the corresponding products in good to excellent yields. Both of the reagents in the catalytic system (CuCl2/DMEDA) were inexpensive, conveniently separable and recyclable for more than five cycles. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Product Details of 1012882-90-4

The Article related to iodobenzene thiophenol copper catalyst carbon sulfur bond formation, diphenylsulfane preparation green chem, diiodobenzene diphenyldisulfane copper catalyst carbon sulfur bond formation, bisphenylsulfanyl benzene preparation green chem and other aspects.Product Details of 1012882-90-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On July 15, 2022, Nguyen, Viet D.; Trevino, Ramon; Greco, Samuel G.; Arman, Hadi D.; Larionov, Oleg V. published an article.HPLC of Formula: 1287221-36-6 The title of the article was Tricomponent Decarboxysulfonylative Cross-coupling Facilitates Direct Construction of Aryl Sulfones and Reveals a Mechanistic Dualism in the Acridine/Copper Photocatalytic System. And the article contained the following:

A dual catalytic process that enabled the previously inaccessible, broad-scope, direct conversion of carboxylic acids to aromatic sulfones-centrally important carbonyl group bioisosteric replacements and synthetic intermediates-by a tricomponent decarboxysulfonylative cross-coupling with aryl halides was reported. Detailed mechanistic and computational studies revealed the roles of the copper catalysts, bases and halide anions in channeling the acridine/copper system via a distinct dual catalytic manifold. In contrast to the halide-free decarboxylative conjugate addition that involved cooperative dual catalysis via low-valent copper species, the halide counteranions divert the decarboxysulfonylative cross-coupling with aryl halides through a two-phase, orthogonal relay catalytic manifold, comprising a kinetically coupled (via antithetical inhibitory and activating roles of the base in the two catalytic cycles), mechanistically discrete sequence of a photoinduced, acridine-catalyzed decarboxylative process and a thermal copper-catalyzed arylative coupling. The study underscores the importance of non-innocent roles of counteranions and key redox steps at the interface of catalytic cycles for enabling previously inaccessible dual catalytic transformations. The experimental process involved the reaction of 4-Iodophenylboronic acid MIDA ester(cas: 1287221-36-6).HPLC of Formula: 1287221-36-6

The Article related to carboxylic acid aryl halide potassium metabisulfite acridine copper catalyst, aromatic halide carboxylic acid dabso acridine copper catalyst, aryl sulfone preparation tricomponent decarboxysulfonylative cross coupling reaction and other aspects.HPLC of Formula: 1287221-36-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yoshida, Suguru; Shimomori, Ken; Kim, Youngchan; Hosoya, Takamitsu published an article in 2016, the title of the article was Single C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group.Quality Control of 5-Bromo-2-iodobenzotrifluoride And the article contains the following content:

The transformation of a single C-F bond of trifluoromethylarenes bearing a hydrosilyl group at the ortho position was achieved. The activation of the hydrosilyl group with a trityl cation in the presence of nucleophiles allowed for selective C-F bond functionalization, for example, by allylation, carboxylation, or chlorination. Further derivatization of the resulting fluorosilylarenes afforded various aromatic difluoromethylene compounds The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

The Article related to silylbenzotrifluoride preparation defluorinative monoallylation allyltrimethylsilane trityl cation, fluorobutenyl fluorosilylarene preparation, c−f activation, allylation, fluorine, silanes, trityl cation and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 18, 2007, Saavedra, Oscar Mario; Claridge, Stephen William; Zhan, Lijie; Raeppel, Franck; Vaisburg, Arkadii; Raeppel, Stephane; Deziel, Robert; Mannion, Michael; Zhou, Nancy Z.; Isakovic, Ljubomir published a patent.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Thienopyridine and thienopyrimidine derivatives and their preparation, pharmaceutical compositions, and use as inhibitors of VEGF receptor and HGF receptor signaling for treatment of proliferative diseases. And the patent contained the following:

The invention relates to the inhibition of vascular endothelial growth factor (VEGF) receptor signaling and hepatocyte growth factor (HGF) receptor signaling. The invention provides compounds of formula I and methods for inhibiting VEGF receptor signaling and HGF receptor signaling for treatment of proliferative diseases. Compounds of formula I, wherein T is (un)substituted (hetero)aryl(alkyl), cycloalkyl or heterocyclyl; W is O, S, NH, or NMe; Z is O, S, or NH; X and X1 are independently H, (un)substituted C1-6 alkyl, halo, CN, or NO2; or X and X1 together may form C3-7 cycloalkyl; R1, R2, R3, R4 are independently H, halo, trihalomethyl, CN, NO2, NH2 and derivatives, OH and derivatives, CO2H and derivatives, COH and derivatives, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; R5 is H, CN, (un)substituted (CH2)2-5 (hetero)aryl, (un)substituted C1-6 alkyl, (un)substituted C2-6 alkenyl, C2-6 alkynyl, CH2(CH2)0-4T2, (un)substituted C1-4 alkylcarbonyl, (un)saturated 3- to 7-membered carboxycyclic or heterocyclic group; where T2 is OH, OMe, OEt, NH2, NHMe, or NMe2; Q is CH2, O, S, NH, N(C1-6 alkyl), N(alkyl)aryl, NOMe, NCH2OMe, or NBn; D is C-E or N; L is N or CR where R is H, halo, CN, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; E is E1, E2 or E3 wherein E1 is H, halo, NO2, azido, (un)substituted C1-6 alkyl, C3-10 cycloalkyl, etc.; E2 is (un)substituted alkynes; E3 is (un)substituted heterocyclyl(ene); and the pharmaceutically acceptable salts and complexes thereof are claimed in this invention. Example compound II was prepared by chlorination of thieno[3,2-b]pyridine-7-ol followed by carboxylation and the resulting lithium carboxylate was converted into the corresponding acid chloride, which reacted with dimethylamine to give compound III; compound III underwent coupling with 2-fluoro-4-nitrophenol, and the resulting 7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthienopyridinecarboamide was reduced to give the corresponding arylamine, which was reacted with phenylacetyl isocyanate to give example compound II. Addnl. 329 examples were prepared in this invention. The example compounds were tested for their in vitro HGF receptor and VEGF receptor signaling inhibition and solid tumor growth inhibition. The invention compounds showed inhibitory activity and was reported to have IC50 values less than 50 nM, ≥50 but <250 nM, ≥250 but <500 nM, ≥ 500 nM, or no activity in various assays. Example compound II showed and IC50 of >50 nM for inhibition of VEGF receptors, and this compound also showed tumor growth inhibition (TGI) against several types of tumors. Example compound II had greater than 100% TGI against U87MG, which indicated tumor shrinkage. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to thienopyridine preparation pharmaceutical composition, thienopyrimidine preparation vegf hgf receptor signaling inhibitor, thieno pyridine preparation vegf hgf receptor signaling inhibitor, pyridine thieno preparation treatment proliferative disease, pyrimidine thieno preparation treatment proliferative disease and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fyfe, James W. B.; Valverde, Elena; Seath, Ciaran P.; Kennedy, Alan R.; Redmond, Joanna M.; Anderson, Niall A.; Watson, Allan J. B. published an article in 2015, the title of the article was Speciation control during Suzuki-Miyaura cross-coupling of haloaryl and haloalkenyl MIDA boronic esters.Application of 1287221-36-6 And the article contains the following content:

Effects of aryl halide, water, base, reaction temperature, catalyst precursor and ligand on chemoselectivity of Suzuki coupling of PhBpin with 4-HalC6H4BMIDA, producing 4-PhC6H4Bpin with up to 92% selectivity, were evaluated. Boronic acid solution speciation can be controlled during the Suzuki-Miyaura cross-coupling of haloaryl N-methyliminodiacetic acid (MIDA) boronic esters to enable the formal homologation of boronic acid derivatives The reaction is contingent upon control of the basic biphase and is thermodynamically driven: temperature control provides highly chemoselective access to either BMIDA adducts at room temperature or boronic acid pinacol ester (BPin) products at elevated temperature Control experiments and solubility analyses have provided some insight into the mechanistic operation of the formal homologation process. The experimental process involved the reaction of 4-Iodophenylboronic acid MIDA ester(cas: 1287221-36-6).Application of 1287221-36-6

The Article related to suzuki coupling chemoselectivity pinacol mida boronate preparation biaryl, aryl halide solvent base temperature effect chemoselectivity suzuki coupling, homologation boronate arylene insertion chemoselective suzuki coupling pinacol mida, boron, chemoselectivity, cross-coupling, palladium, speciation and other aspects.Application of 1287221-36-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 2, 2018, Morales, Guilermo A.; Garlich, Joseph R.; Durden, Donald L. published a patent.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate The title of the patent was Preparation of thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors. And the patent contained the following:

The title compounds I-VI [M = (independently) S or O; R1 = H, halo, alkyl, etc.; R2 = VII, VIII (wherein X = C, N, P, P(O), SiRb; n = 0-2; Y = CR1, O, S, NRa, etc.; Z = O or S; R1 = H or independently at each instance any group defined in R1; Rb = H or independently at each instance any group defined in R1; and wherein R2 in III excludes morpholine; Cyc = (un)substituted aryl, heterocycle, carbocycle); R3 = R1; R4 = R1; Rc = a hydrolyzable linker group which is optionally substituted with a targeting agent; Ar = an aryl, heterocycle, or heteroaryl group unsubstituted beyond the attachment to thiophene (or furan) ring; and the R3 substituent is in the meta- or para-positions], useful for treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atherosclerosis, type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-dependent disorder by modulating biol. processes by the inhibition of cell cycle checkpoint targets CDKs, and/or PI3 kinase, and/or bromodomain protein binding to substrates, were prepared E.g., a multi-step synthesis of IX, starting from 6-chloro-1-cyclopentyl-1,5,7-triaza-1H-indene-2-carboxylic acid and dimethylamine hydrochloride salt, was described. Representative compounds I were tested for their affinity toward CDK6, PI3K and BRD4 (data given). Pharmaceutical composition comprising compound I-VI was disclosed. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate

The Article related to thienopyranone furanopyranone preparation kinase bromodomain checkpoint inhibitor antitumor antiviral, proliferative autoimmune disease sepsis treatment antiatherosclerotic thienopyranone furanopyranone preparation, antidiabetic antiobesity antiinflammatory thienopyranone furanopyranone preparation and other aspects.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com