Tag: 300-400

On September 25, 2003, Egbertson, Melissa; Langford, H. Marie; Melamed, Jeffrey Y.; Wai, John S.; Han, Wei; Perlow, Debbie S.; Zhuang, Linghang; Embrey, Mark published a patent.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Preparation of N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors for treatment of HIV infection/AIDS. And the patent contained the following:

Title compounds I [wherein R1 = H or F; R2 = carbamoylalkyl, carbamoyl, triazolyl or tetrazolyl, acylamino and derivatives, 2-oxopyrrolidin-1-yl and analogs, (cyclo)alkoxycarbonyl, COY; Y = azetidinyl, pyrrolidinyl, piperidinyl, morpholino; R3 = H, carbamoyl and derivatives, acylamino, carbamoyl(alkyl/methylthioxy/methyloxy/amino/alkylamino/alkenyl), (un)substituted 5- to 7-membered saturated heterocyclic ring containing 1 to 4 heteroatoms (N, O or S), (un)substituted 7- to 9-bridged azabicycloalkyl saturated ring; or their pharmaceutical acceptable salts] were prepared as HIV-integrase inhibitors for preventing and treating infection by HIV and for preventing, treating or delaying the onset of AIDS. For example, II鈥a was prepared via TEA-acylation of III鈥Cl (preparation given) with 5-(1,1-dioxo-1,2-thiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylic acid (IV) in DMF at room temperature overnight, followed by sodium salt formation by reaction with NaOH at room temperature for 30 min. IV was prepared from 8-hydroxy-1,6-naphthyridine-7-carboxylic acid Me ester in 5 steps by NBS-bromination in CHCl3, O-tosylation in CHCl3, condensation of the bromide with 1,4-butanesultam in DMF in the presence of Cu2O/2,2′-bipyridyl at 120掳 for 4 h, deprotection of tosyl group, and base-catalyzed hydrolysis in MeOH overnight at 60掳. Selected invention compounds inhibited the strand transfer activity of HIV integrase with IC50 < 0.5 渭M. The same compounds inhibited the replication of HIV in T-lymphoid cells with IC95 < 5 渭M. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

The Article related to naphthyridinecarboxamide hiv integrase inhibitor aids composition antiviral, carboxamide naphthyridine hiv replication inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On September 25, 2003, Egbertson, Melissa; Langford, H. Marie; Melamed, Jeffrey Y.; Wai, John S.; Han, Wei; Perlow, Debbie S.; Zhuang, Linghang; Embrey, Mark; Young, Steven D. published a patent.Application of 70931-59-8 The title of the patent was Preparation of N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors for treatment of HIV infection/AIDS. And the patent contained the following:

Title compounds I [wherein R1 = H or F; R2 = carbamoylalkyl, carbamoyl, triazolyl or tetrazolyl, acylamino and derivatives, 2-oxopyrrolidin-1-yl and analogs, (cyclo)alkoxycarbonyl, COY; Y = azetidinyl, pyrrolidinyl, piperidinyl, morpholino; R3 = H, carbamoyl and derivatives, acylamino, carbamoyl(alkyl/methylthioxy/methyloxy/amino/alkylamino/alkenyl), (un)substituted 5- to 7-membered saturated heterocyclic ring containing 1 to 4 heteroatoms (N, O or S), (un)substituted 7- to 9-bridged azabicycloalkyl saturated ring; or their pharmaceutically acceptable salts] were prepared as HIV-integrase inhibitors for preventing and treating infection by HIV and for preventing, treating or delaying the onset of AIDS. For example, II鈥a was prepared via TEA-acylation of III鈥Cl (preparation given) with 5-(1,1-dioxo-1,2-thiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylic acid (IV) in DMF at room temperature overnight, followed by sodium salt formation by reaction with NaOH at room temperature for 30 min. IV was prepared from 8-hydroxy-1,6-naphthyridine-7-carboxylic acid Me ester in 5 steps by NBS-bromination in CHCl3, O-tosylation in CHCl3, condensation of the bromide with 1,4-butanesultam in DMF in the presence of Cu2O/2,2′-bipyridyl at 120掳 for 4 h, deprotection of tosyl group, and base-catalyzed hydrolysis in MeOH overnight at 60掳. Selected invention compounds inhibited the strand transfer activity of HIV integrase with IC50 < 0.5 渭M. The same compounds inhibited HIV replication in T-lymphoid cells with IC95 < 5 渭M. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Application of 70931-59-8

The Article related to naphthyridinecarboxamide hiv integrase inhibitor aids composition antiviral, carboxamide naphthyridine hiv replication inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 15, 2002, Tobe, Yoshito; Utsumi, Naoto; Kawabata, Kazuya; Nagano, Atsushi; Adachi, Kiyomi; Araki, Shunji; Sonoda, Motohiro; Hirose, Keiji; Naemura, Koichiro published an article.Safety of Ethyl 4-amino-3-bromo-5-iodobenzoate The title of the article was m-Diethynylbenzene Macrocycles: Syntheses and Self-Association Behavior in Solution. And the article contained the following:

M-Diethynylbenzene macrocycles (DBMs), buta-1,3-diyne-bridged [4n]metacyclophanes, have been synthesized and their self-association behaviors in solution were investigated. Cyclic tetramers, hexamers, and octamers of DBMs having exo-annular octyl, hexadecyl, and 3,6,9-trioxadecyl ester groups were prepared by intermol. oxidative coupling of dimer units or intramol. cyclization of the corresponding open-chain oligomers. The aggregation properties were investigated by two methods, the 1H NMR spectra and the vapor pressure osmometry (VPO). Although some discrepancies were observed between the association constants obtained from the two methods, the qual. view was consistent with each other. The anal. of self-aggregation by VPO revealed unique aggregation behavior of DBMs in acetone and toluene, which was not elucidated by the NMR method. Namely, the association constants for infinite association are several times larger than the dimerization constant, suggesting that the aggregation is enhanced by the formation of dimers (a nucleation mechanism). In polar solvents, DBMs aggregate more strongly than in chloroform due to the solvophobic interactions between the macrocyclic framework and the solvents. Moreover, DBMs self-associate in aromatic solvents such as toluene and o-xylene more readily than in chloroform. In particular, the hexameric DBM having a large macrocyclic cavity exhibits extremely large association constants in aromatic solvents. By comparing the aggregation properties of DBMs with the corresponding acyclic oligomers, the effect of the macrocyclic structure on the aggregation propensity was clarified. Finally, it turned out that DBMs tend to aggregate more readily than the corresponding phenylacetylene macrocycles, acetylene-bridged [2n]metacyclophanes, owing to the withdrawal of the electron d. from the aromatic rings by the butadiyne linkages which facilitates 蟺-蟺 stacking interactions. The experimental process involved the reaction of Ethyl 4-amino-3-bromo-5-iodobenzoate(cas: 437707-51-2).Safety of Ethyl 4-amino-3-bromo-5-iodobenzoate

The Article related to nmr vapor pressure osmometry selfassocn preparation thermodn diethynylbenzene macrocycle, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Safety of Ethyl 4-amino-3-bromo-5-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 6, 2016, Welz, Claudia; Koehler, Adeline; Boerngen, Kirsten; Kulke, Daniel; Goergens, Ulrich; Schwarz, Hans-Georg; Ilg, Kerstin published a patent.Computed Properties of 364-12-5 The title of the patent was Preparation of arylamide compounds for use in anthelmintic treatment. And the patent contained the following:

Disclosed are compounds of formula I which possess anthelmintic properties wherein the structural elements have the meaning as indicated in the description. Further disclosed are such compounds for the control, treatment and/or prevention of infections with helminths in animals and humans. Compounds of formula I wherein n is 1, 2 and 3; m is 0, 1, 2, 3 and 4; R1 is H, CHO, OH, C1-4 alkyl,e tc.; each X is independently halo, NO2, CN, amino, etc.; each Y is independently H, halo, NO2, CN, OH, SH, etc.; A is (un)substituted Ph, (un)substituted pyridinyl and (un)substituted pyrazinyl; and salts, solvates, solvates of salts, N-oxides, metal complexes and metalloid complexes thereof, are claimed. Example compound II was prepared by amidation of 2-trifluoromethylbenzoyl chloride with 2-(4-bromo-2- chloro-phenyl)-2,2-difluoro-ethanamine; the resulting N-[2-(4-bromo-2-chloro-phenyl)-2,2-difluoro-ethyl]-2-(trifluoromethyl)benzamide underwent cross-coupling with 4-fluorophenylboronic acid to give compound II. The invention compounds were evaluated for their anthelmintic activity (some data given). The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Computed Properties of 364-12-5

The Article related to arylamide preparation anthelmintic, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Computed Properties of 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On May 17, 2022, Kusakabe, Yu; Wada, Yoshimasa; Misono, Tomoya; Suzuki, Katsuaki; Shizu, Katsuyuki; Kaji, Hironori published an article.Recommanded Product: 5-Bromo-2-iodobenzotrifluoride The title of the article was Imidazole Acceptor for Both Vacuum-Processable and Solution-Processable Efficient Blue Thermally Activated Delayed Fluorescence. And the article contained the following:

The members of the imidazole family have been widely used for electron transporting, host, conventional fluorescent, and phosphorescent materials. Although the imidazole core also has great potential as an acceptor segment of deep-blue thermally activated delayed fluorescence (TADF) owing to its high triplet energy, the emission color of imidazole-based TADF organic light-emitting diodes (OLEDs) has so far been limited to blue to green. In this work, four acridan-imidazole systems are theor. designed aiming for deep- or pure-blue emitters. All four emitters exhibit deep-blue to blue emission owing to the high energy levels of the lowest excited singlet states, exhibiting y coordinates of Commission Internationale de l’Eclairage coordinates between 0.06 and 0.26. The mol. composed of a trifluoromethyl-substituted benzimidazole acceptor in combination with a tetramethyl-9,10-dihydroacridine donor (named MAc-FBI) achieves a high maximum external quantum efficiency (EQEMAX) of 13.7% in its application to vacuum-processed OLEDs. The emitter has high solubility even in ecofriendly nonhalogenated solvents, which motivates us to fabricate solution-processed MAc-FBI-based OLEDs, resulting in an even higher EQEMAX of 16.1%. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Recommanded Product: 5-Bromo-2-iodobenzotrifluoride

The Article related to imidazole acceptor vacuum processable solution blue thermally activated fluorescence, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Structure Correlation With Physical Properties and other aspects.Recommanded Product: 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On December 5, 2019, Pitts, Cody Ross; Santschi, Nico; Togni, Antonio published a patent.Product Details of 364-12-5 The title of the patent was Method for preparing polyfluorinated compound. And the patent contained the following:

The present invention relates to a process for preparing a polyfluorinated compound of formula Ar-Ri , wherein Ar-Ri(I) is an aromatic ring system wherein R1 is selected from the group consisting of SF4CI, SF3, SF2CF3, TeFS, TeF4CF3, SeF3, IF2, SeF2CF3, and IF4, X2 is N or CR2, X3 is N or CR3, X4 is N or CR4 , X5 is N or CR5, X 6 is N or CR6, and the total number of nitrogen atoms in the aromatic ring system is between 0 and 3, and if X5 is CR5 and X6 is CR6 R5 and R6 may form together a saturated or unsaturated five or six membered ring system comprising one or more nitrogen, wherein said five or six membered ring system may be substituted with one or more residues R 7 said process involving the following reaction step reacting a starting material selected from the group consisting of Ar2S2, Ar2Te2, Ar2Se2, ArSCF3, Arl, ArTeCF3, ArSeCF3, ArSCF3, and ArSCl, wherein Ar has the same definition as above, with trichloroisocyanuric acid (TCICA) in the presence of the alkali metal fluoride (MF). The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Product Details of 364-12-5

The Article related to trichloroisocyanuric acid alkali metal fluoride fluorination reagent, polyfluorinated compound preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Product Details of 364-12-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Galan, Elena; Perrin, Mickael L.; Lutz, Martin; van der Zant, Herre S. J.; Grozema, Ferdinand C.; Eelkema, Rienk published an article in 2016, the title of the article was Synthesis of 1,2-biphenylethane based single-molecule diodes.Application In Synthesis of 5-Bromo-2-iodobenzotrifluoride And the article contains the following content:

We have described the synthesis of novel biphenylethane-based wires for mol. electronics. Exceptional single-mol. diode behavior was predicted for unsym. substituted biphenylethane derivatives, synthesized here using the so far unexplored unsym. substituted 1,2-bis(4-bromophenyl)ethanes as key intermediates, which were obtained from the corresponding tolane precursor by selective hydrogenation. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Application In Synthesis of 5-Bromo-2-iodobenzotrifluoride

The Article related to ethynyl ethylnylphenethyldifluorobenzene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application In Synthesis of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On March 5, 2021, Provencher, Philip A.; Bay, Katherine L.; Hoskin, John F.; Houk, K. N.; Yu, Jin-Quan; Sorensen, Erik J. published an article.HPLC of Formula: 70931-59-8 The title of the article was Cyclization by C(sp3)-H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes. And the article contained the following:

Pd(II)-catalyzed cyclative C(sp3)-H arylation of ketones with a transient directing group (TDG). Based on calculations, the oxidative addition step implicates a highly strained trigonal bipyramidal geometry around a Pd(IV) intermediate afforded by the bidentate TDG and the intramol. arylation process. As a consequence, unproductive protodeiodination outcompetes the cyclative arylation Pd(II/IV) pathway under standard conditions. The desired selectivity was achieved by prudent selection of the TDG and the Ag(I) source. The reaction was accelerated by the inclusion of stoichiometric quantities of trifluoroacetic acid, which benefits both the palladium catalysis and the attachment of the TDG for the pivotal C(sp3)-H palladation. Critically, the use of the 2-pyridone ligand improves yields significantly and enables the cyclative arylation of both Me and linear methylene C-H bonds. Mechanistically, the high energy barrier associated with the transition state of this cyclization type was sufficient to drive selective linear methylene C-H activation in the presence of a more reactive Me C-H bond. The reaction was showcased in a two-step synthesis of a substituted indane using 3-iodoanisole as the linchpin in a formal [3 + 2] annulation concept featuring two C(sp3)-H arylations. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).HPLC of Formula: 70931-59-8

The Article related to iodophenyl alkyl ketone palladium acetate catalyst glycine cyclization diastereoselective, alkyl dihydroindenyl ethanone preparation c h activation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Benzocyclopropenes, Benzocyclobutenes, and Indenes and other aspects.HPLC of Formula: 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On September 14, 2017, Janetka, James W.; Mydock-McGrane, Laurel published a patent.Quality Control of 5-Bromo-2-iodobenzotrifluoride The title of the patent was Preparation of C-glycoside compounds useful for treating urinary tract infection. And the patent contained the following:

The present invention relates to mannosides I, wherein Ar is aryl, heteroaryl; Y1 and Y2 are independently H, hydroxyl, alkoxy, amino; were prepared and are useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection, bacterial infection, Crohn’s disease, and inflammatory bowel disease. Thus, glycoside II was prepared and tested for its hemagglutination (EC>90 = 0.006 μM) inhibition and as FimH inhibitor. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Quality Control of 5-Bromo-2-iodobenzotrifluoride

The Article related to antibacterial antagonist hemagglutination urinary tract infection glycoside preparation mannoside, alkyne azide cycloaddition suzuki coupling fimh inhibitor human antibiotic, triazole click preparation c glycoside urinary tract infection and other aspects.Quality Control of 5-Bromo-2-iodobenzotrifluoride

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On January 31, 2022, Shen, Guodong; Lu, Qichao; Wang, Zeyou; Sun, Weiwei; Zhang, Yalin; Huang, Xianqiang; Sun, Manman; Wang, Zhiming published an article.Product Details of 1012882-90-4 The title of the article was Environmentally Friendly and Recyclable CuCl2 -Mediated C-S Bond Coupling Strategy Using DMEDA as Ligand, Base and Solvent. And the article contained the following:

An environment-friendly, recyclable and economic strategy was developed to synthesize diaryl chalcogenides by the CuCl2-catalyzed C-S bond-formation reaction via iodobenzenes and benzenethiols/1,2-diphenyldisulfanes using N,N’-dimethylethane-1,2-diamine (DMEDA) as ligand, base and solvent. For these reactions, especially the reactions of diiodobenzenes and aminobenzenethiols/disulfanediyldianilines, a range of substrates were compatible and gave the corresponding products in good to excellent yields. Both of the reagents in the catalytic system (CuCl2/DMEDA) were inexpensive, conveniently separable and recyclable for more than five cycles. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Product Details of 1012882-90-4

The Article related to iodobenzene thiophenol copper catalyst carbon sulfur bond formation, diphenylsulfane preparation green chem, diiodobenzene diphenyldisulfane copper catalyst carbon sulfur bond formation, bisphenylsulfanyl benzene preparation green chem and other aspects.Product Details of 1012882-90-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com