Tag: 300-400

ortho-Metalation of Unprotected 3-Bromo and 3-Chlorobenzoic Acids with Hindered Lithium Dialkylamides was written by Gohier, Frederic;Mortier, Jacques. And the article was included in Journal of Organic Chemistry in 2003.Recommanded Product: 503821-94-1 This article mentions the following:

Upon treatment of 3-chloro/bromobenzoic acids with hindered lithium dialkylamides (LDA or LTMP) at -50 鎺矯, lithium 3-chloro/bromo-2-lithiobenzoates are generated. These dianions can be trapped as such to afford after electrophilic quenching a variety of simple 2-substituted-3-chloro/bromobenzoic acids. The 3-bromo-2-lithiobenzoate is less stable than the 3-chloro analog and partly eliminates lithium bromide, thus setting free lithium 2,3- and 3,4-dehydrobenzoates that can be intercepted in situ with the hindered base. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-iodobenzoic acid (cas: 503821-94-1Recommanded Product: 503821-94-1).

3-Bromo-2-iodobenzoic acid (cas: 503821-94-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 503821-94-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase was written by Ding, Min;He, Feng;Hudyma, Thomas W.;Zheng, Xiaofan;Poss, Michael A.;Kadow, John F.;Beno, Brett R.;Rigat, Karen L.;Wang, Ying-Kai;Fridell, Robert A.;Lemm, Julie A.;Qiu, Dike;Liu, Mengping;Voss, Stacey;Pelosi, Lenore A.;Roberts, Susan B.;Gao, Min;Knipe, Jay;Gentles, Robert G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: iodides-buliding-blocks This article mentions the following:

Presented here are initial structure-activity relationship (SAR) studies on a series of novel heteroaryl fused tetracyclic indole-based inhibitors of the hepatitis C viral polymerase, NS5B. The introduction of alternative heterocyclic moieties into the indolo-fused inhibitor class significantly expands the reported SAR and resulted in the identification of pyridino analogs, typified by compounds I and II that displayed excellent potency against the NS5B polymerase of both HCV 1a and HCV 1b genotypes. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Category: iodides-buliding-blocks).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalyst as colour indicator for endpoint detection to enable selective alkyne trans-hydrogenation with ethanol was written by Wang, Yulei;Huang, Zhidao;Huang, Zheng. And the article was included in Nature Catalysis in 2019.Safety of N,N-Diethyl-4-iodobenzamide This article mentions the following:

An iridium complex catalyzed semi-hydrogenation of internal alkynes using ethanol as hydrogen donor to afford E-alkenes and Et acetate was reported. Importantly, issues of over-reduction and stereoselection was successfully addressed by using a color change effect due to shift of catalyst resting states, thereby precisely detecting the endpoint of the reaction. This catalytic system was applicable to a wide variety of internal alkynes bearing many auxiliary functional groups, and its utility for synthesis of biol. relevant mols. was also demonstrated. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Safety of N,N-Diethyl-4-iodobenzamide).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of N,N-Diethyl-4-iodobenzamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stannyl-Lithium: A Facile and Efficient Synthesis Facilitating Further Applications was written by Wang, Dong-Yu;Wang, Chao;Uchiyama, Masanobu. And the article was included in Journal of the American Chemical Society in 2015.Synthetic Route of C11H14INO This article mentions the following:

We have developed a highly efficient, practical, polycyclic aromatic hydrocarbon (PAH)-catalyzed synthesis of stannyl lithium (Sn-Li), in which the tin resource (stannyl chloride or distannyl) is rapidly and quant. transformed into Sn-Li reagent at room temperature without formation of any (toxic) byproducts. The resulting Sn-Li reagent can be stored at ambient temperature for months and shows high reactivity toward various substrates, with quant. atom efficiency. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Synthetic Route of C11H14INO).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C11H14INO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

ortho-Metalation of Unprotected 3-Bromo and 3-Chlorobenzoic Acids with Hindered Lithium Dialkylamides was written by Gohier, Frederic;Mortier, Jacques. And the article was included in Journal of Organic Chemistry in 2003.Recommanded Product: 503821-94-1 This article mentions the following:

Upon treatment of 3-chloro/bromobenzoic acids with hindered lithium dialkylamides (LDA or LTMP) at -50 °C, lithium 3-chloro/bromo-2-lithiobenzoates are generated. These dianions can be trapped as such to afford after electrophilic quenching a variety of simple 2-substituted-3-chloro/bromobenzoic acids. The 3-bromo-2-lithiobenzoate is less stable than the 3-chloro analog and partly eliminates lithium bromide, thus setting free lithium 2,3- and 3,4-dehydrobenzoates that can be intercepted in situ with the hindered base. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-iodobenzoic acid (cas: 503821-94-1Recommanded Product: 503821-94-1).

3-Bromo-2-iodobenzoic acid (cas: 503821-94-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 503821-94-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase was written by Ding, Min;He, Feng;Hudyma, Thomas W.;Zheng, Xiaofan;Poss, Michael A.;Kadow, John F.;Beno, Brett R.;Rigat, Karen L.;Wang, Ying-Kai;Fridell, Robert A.;Lemm, Julie A.;Qiu, Dike;Liu, Mengping;Voss, Stacey;Pelosi, Lenore A.;Roberts, Susan B.;Gao, Min;Knipe, Jay;Gentles, Robert G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: iodides-buliding-blocks This article mentions the following:

Presented here are initial structure-activity relationship (SAR) studies on a series of novel heteroaryl fused tetracyclic indole-based inhibitors of the hepatitis C viral polymerase, NS5B. The introduction of alternative heterocyclic moieties into the indolo-fused inhibitor class significantly expands the reported SAR and resulted in the identification of pyridino analogs, typified by compounds I and II that displayed excellent potency against the NS5B polymerase of both HCV 1a and HCV 1b genotypes. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Category: iodides-buliding-blocks).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

C-H functionalization of amines with aryl halides by nickel-photoredox catalysis was written by Ahneman, Derek T.;Doyle, Abigail G.. And the article was included in Chemical Science in 2016.SDS of cas: 77350-52-8 This article mentions the following:

Synthesis of phenylpyrrolidines e.g., I via functionalization of α-amino C-H bonds with aryl halides using a combination of nickel and photoredox catalysis was described. This direct C-H, C-X coupling uses inexpensive and readily available starting materials to generate benzylic amines, an important class of bioactive mols. Mechanistically, this method features the direct arylation of α-amino radicals mediated by a nickel catalyst. This reactivity was demonstrated for a range of aryl halides and N-aryl amines, with orthogonal scope to existing C-H activation and photoredox methodologies. Reactions with several complex aryl halides, demonstrating the potential utility of this approach in late-stage functionalization was also reported. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8SDS of cas: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.SDS of cas: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Molybdenum-Mediated Carbonylation of Aryl Halides with Nucleophiles Using Microwave Irradiation was written by Roberts, Bryan;Liptrot, David;Alcaraz, Lilian;Luker, Tim;Stocks, Michael J.. And the article was included in Organic Letters in 2010.SDS of cas: 77350-52-8 This article mentions the following:

A new, efficient, and practical molybdenum-mediated carbonylation of aryl and heteroaryl halides with a variety of nucleophiles is described using microwave irradiation A range of reactions illustrating the wide scope of this chem. were carried out and proceeded in good to excellent yields. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8SDS of cas: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

From an Eight-Component Self-Sorting Algorithm to a Trisheterometallic Scalene Triangle was written by Mahata, Kingsuk;Saha, Manik Lal;Schmittel, Michael. And the article was included in Journal of the American Chemical Society in 2010.Related Products of 3268-21-1 This article mentions the following:

Using motifs from 3-fold completive self-sorting in an eight-component library, the authors report on the design and fabrication of a fully dynamic trisheterometallic scalene triangle, a demanding supramol. structure that complements the so far known triangular structures. The trisheterometallic scalene triangle complexes have the compositions [CuZn(7)(8)(9)](OTf)₂(PF₆) and [CuHg(7)(8)(9)](ClO₄)₂(PF₆) (7 = (5-(4-(2,9-bis(2,6-dimethoxyphenyl)-1,10-phenanthrolin-3-ylethynyl)phenyl)-10,15,20-trimesitylporphyrinato)zinc, 8 = 4′-(4-(1,10-phenanthrolin-3-ylethynyl)phenyl)-2,2′:6′,2”-terpyridine, 9 = 2-(4-bromo-2,3,5,6-tetramethylphenyl)-9-mesityl-3-((4-(pyridin-4-ylethynyl)-2,3,5,6-tetramethylphenyl)ethynyl)-1,10-phenanthroline). In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Related Products of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Related Products of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Early Process Development of an Irreversible Epidermal Growth Factor Receptor (EGFR) T790 M Inhibitor was written by Tao, Yong;Keene, Nandell F.;Wiglesworth, Kristin E.;Sitter, Barbara;McWilliams, J. Christopher. And the article was included in Organic Process Research & Development in 2019.Synthetic Route of C6H2Cl2IN3 This article mentions the following:

The original synthesis of the irreversible epidermal growth factor receptor (EGFR) T790 M inhibitor 1 (I) was enabled by successful application of ammonium hydroxide to cleanly cleave the N-hydroxymethyl group and by development of high yielding conditions for the subsequent amidation reaction. Furthermore, a protection-free and regioselective new synthetic route was developed that shortened the synthesis from the original 8 steps to 6 steps and improved the overall yield from 5% to 34% on scale. Crystallizations of 1 and intermediates were correspondingly developed to control the quality en route. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1Synthetic Route of C6H2Cl2IN3).

2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Synthetic Route of C6H2Cl2IN3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com