Tag: 300-400

A novel synthetic approach towards chiral QUINAP via diastereomeric sulfoxide intermediates was written by Thaler, Tobias;Geittner, Florian;Knochel, Paul. And the article was included in Synlett in 2007.Application In Synthesis of 2-Bromo-1-iodonaphthalene The following contents are mentioned in the article:

A novel enantioselective synthesis of chiral QUINAP is described. Hereby, the separation of the diastereomers was achieved by the preparation and simple chromatog. separation of chiral sulfoxide intermediates. Subsequent sulfoxide-lithium exchange, quenching with Ph₂PCl and sulfur, and then desulfurization with Raney-Ni provided (R)- and (S)-QUINAP in 54-56% overall yield. This study involved multiple reactions and reactants, such as 2-Bromo-1-iodonaphthalene (cas: 676267-05-3Application In Synthesis of 2-Bromo-1-iodonaphthalene).

2-Bromo-1-iodonaphthalene (cas: 676267-05-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of 2-Bromo-1-iodonaphthalene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nitrodiphenyl ethers from 1,2- or 1,4-dinitrobenzenes and copper in pyridine was written by Bjorklund, Christer;Wahren, Robert. And the article was included in Acta Chemica Scandinavica in 1976.Computed Properties of C12H8INO3 The following contents are mentioned in the article:

Reaction of o-C6H4(NO2)2 (I) with Cu in pyridine at 116掳 gave 65% (o-O2NC6H4)2O (II); 77% (p-O2NC6H4)2O was obtained from p-C6H4(NO2)2 similarly. Treatment of I with Cu in pyridine and BuX (X = I, Br, Cl) gave o-BuOC6H4NO2, II, and o-O2NC6H4OH (III). Reaction of the dinitrobenzenes, Cu, and phenols in boiling pyridine gave unsym. diaryl ether, sym. diaryl ether and III. This study involved multiple reactions and reactants, such as 1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1Computed Properties of C12H8INO3).

1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Computed Properties of C12H8INO3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ir-Catalyzed Synthesis of Substituted Tribenzosilepins by Dehydrogenative C-H/Si-H Coupling was written by Shibata, Takanori;Uno, Ninna;Sasaki, Tomoya;Takano, Hideaki;Sato, Tatsuki;Kanyiva, Kyalo Stephen. And the article was included in Journal of Organic Chemistry in 2018.Computed Properties of C10H6BrI The following contents are mentioned in the article:

The Ir-catalyzed intramol. reaction of 2′,6′-diaryl-2-(hydrosilyl)biphenyls gave substituted tribenzosilepins by direct dehydrogenative C-H/Si-H coupling. This is the 1st example of catalytic construction of the tribenzosilepin skeleton. Enantiomerically pure tribenzosilepin was prepared by optical resolution using chiral HPLC, and its inversion barrier was calculated by measurement of rate of racemization using the Eyring kinetic equation under heating conditions. This study involved multiple reactions and reactants, such as 2-Bromo-1-iodonaphthalene (cas: 676267-05-3Computed Properties of C10H6BrI).

2-Bromo-1-iodonaphthalene (cas: 676267-05-3) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Computed Properties of C10H6BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Trifluoromethylthiolation of Unsymmetrical 位³-Iodane Derivatives: Additive-Free, Selective and Scalable Introduction of the SCF₃ Group was written by Nikolaienko, Pavlo;Yildiz, Tuelay;Rueping, Magnus. And the article was included in European Journal of Organic Chemistry in 2016.Recommanded Product: 1-Iodo-4-(4-nitrophenoxy)benzene The following contents are mentioned in the article:

The reaction of copper trifluoromethyl sulfide with diaryliodonium salts provides a straightforward pathway for the synthesis of aryl trifluoromethyl thioethers under mild reaction conditions and within short reaction times. High chemoselectivity was achieved by using mesityl as a leaving group. A large range of novel [(het)aryl](mesityl)iodonium salts underwent this reaction under the optimized conditions to give the desired products in moderate to good yields. This study involved multiple reactions and reactants, such as 1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1Recommanded Product: 1-Iodo-4-(4-nitrophenoxy)benzene).

1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 1-Iodo-4-(4-nitrophenoxy)benzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes was written by Yuan, Zhenbo;Feng, Ziwen;Zeng, Yuye;Zhao, Xiaobin;Lin, Aijun;Yao, Hequan. And the article was included in Angewandte Chemie, International Edition in 2019.Category: iodides-buliding-blocks The following contents are mentioned in the article:

A palladium-catalyzed asym. reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β-hydrogen atoms, was realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibited good functional-group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4Category: iodides-buliding-blocks).

Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

An efficient and mild ortho-zincation of aromatics and heterocycles by using TMP₂Mg·2LiCl in the presence of ZnCl₂ was written by Dong, Zhi-Bing;Zhu, Wei-Hua;Zhang, Zhi-Guang;Li, Min-Zhi. And the article was included in Journal of Organometallic Chemistry in 2010.COA of Formula: C9H8ClIO2 The following contents are mentioned in the article:

A variety range of functionalized aryl and heteroaryl zinc reagents were efficiently generated by using TMP₂Mg·2LiCl (TMP = 2,2,6,6-tetramethylpiperidinyl) in the presence of ZnCl₂. The subsequently functionalization gave after reaction with electrophiles the expected polyfunctionalized products in good yields. E.g., metalation of pyrazine with ZnCl₂, followed by TMP₂Mg·2LiCl, then treatment with I₂, gave 71% 2-iodopyrazine. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4COA of Formula: C9H8ClIO2).

Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.COA of Formula: C9H8ClIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

CsF/clinoptilolite: an efficient solid base in S_NAr and copper-catalyzed Ullmann reactions was written by Keipour, Hoda;Hosseini, Abolfazl;Afsari, Amir;Oladee, Razieh;Khalilzadeh, Mohammad A.;Ollevier, Thierry. And the article was included in Canadian Journal of Chemistry in 2016.Application In Synthesis of 1-Iodo-4-(4-nitrophenoxy)benzene The following contents are mentioned in the article:

CsF/clinoptilolite was found to be an efficient solid base catalyst for both S_NAr and Ullmann ether reactions. A general and efficient one-step procedure was developed for the synthesis of biaryl ethers via direct coupling of electron-deficient aryl halides to phenols using CsF/clinoptilolite. The protocol was also applied to electron-rich aryl halides by addition of a catalytic amount of copper oxide nanoparticles. Both S_NAr and Ullmann reactions were rapid and provided good to excellent yields. This study involved multiple reactions and reactants, such as 1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1Application In Synthesis of 1-Iodo-4-(4-nitrophenoxy)benzene).

1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Application In Synthesis of 1-Iodo-4-(4-nitrophenoxy)benzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ligand-free solid supported palladium(0) nano/microparticles promoted C-O, C-S, and C-N cross coupling reaction was written by Bandna;Guha, Nitul Ranjan;Shil, Arun K.;Sharma, Dharminder;Das, Pralay. And the article was included in Tetrahedron Letters in 2012.Name: 1-Iodo-4-(4-nitrophenoxy)benzene The following contents are mentioned in the article:

Ligand-free solid-supported nano and microparticles of Pd(0) (SS-Pd) were used as a heterogeneous catalyst in carbon-heteroatom bond formation reactions. Nitro substituted aryl halides reacted with oxygen, sulfur, and nitrogen nucleophiles to afford the corresponding products in good yields. A one-pot sequential cross coupling and nitro-reduction was also performed using the same SS-Pd catalyst to access amine substituted carbon-heteroat. mols. In addition, SS-Pd could be recycled up to seven runs without a significant loss of catalytic activity. This study involved multiple reactions and reactants, such as 1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1Name: 1-Iodo-4-(4-nitrophenoxy)benzene).

1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Name: 1-Iodo-4-(4-nitrophenoxy)benzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Interaction of functional groups through π-electron systems. V. Interaction through aromatic rings connected by a monofunctional bridging group was written by Lutskii, A. E.;Obukhova, E. M.;Cheshko, R. S.. And the article was included in Zhurnal Fizicheskoi Khimii in 1968.Application of 21969-05-1 The following contents are mentioned in the article:

Dipole moments (μH) of 4-XC6H4ZC6H4Y-4′ where Z was CH2, O, S, NH, and CH2CH2 and X and Y were NO2, CN, Cl, Br, I, OH, Me, and NH2 were measured. Values of μH prove existence of the interaction of the substituents in 4,4′ position through bridges with σ and p electrons. Any change in the electron d. at Z in the case of its interaction with substituents of the 1st ring causes a change in degree of its interaction with substituents of the 2nd ring. Only electron effects are transmitted from one substituent to the other substituents of the rings through the bridging groups. This study involved multiple reactions and reactants, such as 1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1Application of 21969-05-1).

1-Iodo-4-(4-nitrophenoxy)benzene (cas: 21969-05-1) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application of 21969-05-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

[2+2+2] Cycloisomerisation of Aromatic Cyanodiynes in the Synthesis of Pyridohelicenes and Their Analogues was written by Klivar, Jiri;Jancarik, Andrej;Saman, David;Pohl, Radek;Fiedler, Pavel;Bednarova, Lucie;Stary, Ivo;Stara, Irena G.. And the article was included in Chemistry – A European Journal in 2016.Electric Literature of C10H6BrI The following contents are mentioned in the article:

We have developed a methodol. for the synthesis of pyridohelicenes and their analogs based on the Ni⁰-, Co^I– or Rh^I-mediated intramol. [2+2+2] cycloisomerization of cyanodiynes. It allows for folding the linear precursors into the corresponding helical backbones comprising the newly formed pyridine unit in their central part. Along with racemic pyrido[n]helicenes (n=5,6,7) and their derivatives, both enantio- and diastereomerically pure pyrido[n]helicene-like mols. (n=5,6) were prepared by employing the chiral substrate-controlled cyclization of the corresponding enantiopure cyanodiynes. This study involved multiple reactions and reactants, such as 2-Bromo-1-iodonaphthalene (cas: 676267-05-3Electric Literature of C10H6BrI).

2-Bromo-1-iodonaphthalene (cas: 676267-05-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Electric Literature of C10H6BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com