Tag: 300-400

Synthesis and Properties of Oligonucleotides with Iodo-Substituted Aromatic Aglycons: Investigation of Possible Halogen Bonding Base Pairs was written by Tawarada, Ryuya;Seio, Kohji;Sekine, Mitsuo. And the article was included in Journal of Organic Chemistry in 2008.Formula: C3H2I2N2 This article mentions the following:

Ab initio calculations of halogen bond energies of artificial base pairs constructed between iodinated aromatic nucleobase mimics and nitrogen-containing acceptor mols. such as pyridine and imidazole suggest that modified base pairs are converted to optimized planar base pairs with weak ΔE values of -0.19 to -3.93 kcal/mol. To evaluate the contribution of halogen bonding toward duplex stabilization of such modified nucleobase mimics introduced into artificial base pairs, three C-nucleoside analogs I and II (R = H and F) with several iodinated aromatic rings and an imidazole nucleoside derivative III were synthesized, and they were incorporated into oligodeoxynucleotides. Hybridization studies of modified oligodeoxynucleotides incorporating iodoarom. bases showed their unique universal base-like ability; however, no indication of halogen bond formation was observed A more sophisticated design is required for the development of new base pairs stabilized by halogen bonding. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Formula: C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Formula: C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed alkoxycarbonylation of unactivated secondary alkyl bromides at low pressure was written by Sargent, Brendon T.;Alexanian, Erik J.. And the article was included in Journal of the American Chemical Society in 2016.Product Details of 77350-52-8 This article mentions the following:

Catalytic carbonylations of organohalides are important C-C bond formations in chem. synthesis. Carbonylations of unactivated alkyl halides remain a challenge and currently require the use of alkyl iodides under harsh conditions and high pressures of CO. Herein we report a palladium-catalyzed alkoxycarbonylation of secondary alkyl bromides that proceeds at low pressure (2 atm CO) under mild conditions. Preliminary mechanistic studies are consistent with a hybrid organometallic-radical process. These reactions efficiently deliver esters from unactivated alkyl bromides across a diverse range of substrates and represent the first catalytic carbonylations of alkyl bromides with carbon monoxide. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Product Details of 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A general carbonyl alkylative amination for tertiary amine synthesis was written by Kumar, Roopender;Floden, Nils J.;Whitehurst, William G.;Gaunt, Matthew J.. And the article was included in Nature (London, United Kingdom) in 2020.Quality Control of 1-Bromo-4-(2-iodoethyl)benzene This article mentions the following:

The ubiquity of tertiary alkylamines in pharmaceutical and agrochem. agents, natural products and small-mol. biol. probes has stimulated efforts towards their streamlined synthesis. Arguably the most robust method for the synthesis of tertiary alkylamines is carbonyl reductive amination, which comprises two elementary steps: the condensation of a secondary alkylamine with an aliphatic aldehyde to form an all-alkyl-iminium ion, which is subsequently reduced by a hydride reagent. Direct strategies were sought for a ‘higher order’ variant of this reaction via the coupling of an alkyl fragment with an alkyl-iminium ion that was generated in situ. However, despite extensive efforts, the successful realization of a ‘carbonyl alkylative amination’ has not yet been achieved. Here the authors present a practical and general synthesis of tertiary alkylamines through the addition of alkyl radicals to all-alkyl-iminium ions. The process is facilitated by visible light and a silane reducing agent, which trigger a distinct radical initiation step to establish a chain process. This operationally straightforward, metal-free and modular transformation forms tertiary amines, without structural constraint, via the coupling of aldehydes and secondary amines with alkyl halides. The structural and functional diversity of these readily available precursors provides a versatile and flexible strategy for the streamlined synthesis of complex tertiary amines. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Quality Control of 1-Bromo-4-(2-iodoethyl)benzene).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Quality Control of 1-Bromo-4-(2-iodoethyl)benzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2′-deoxy nucleoside analogues was written by Wauchope, Orrette R.;Johnson, Cameron;Krishnamoorthy, Pasupathy;Andrei, Graciela;Snoeck, Robert;Balzarini, Jan;Seley-Radtke, Katherine L.. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Product Details of 15813-09-9 This article mentions the following:

Introducing structural diversity into the nucleoside scaffold for use as potential chemotherapeutics has long been considered an important approach to drug design. In that regard, we have designed and synthesized a number of innovative 2′-deoxy expanded nucleosides, e.g. I, where a heteroaromatic thiophene spacer ring has been inserted in between the imidazole and pyrimidine ring systems of the natural purine scaffold. The synthetic efforts towards realizing the expanded 2′-deoxy-guanosine and -adenosine tricyclic analogs as well as the preliminary biol. results are presented herein. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Product Details of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Product Details of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Regioselective synthesis of 1-benzyl- and 1-methyl-4-vinylimidazole and their reactions with N-phenylmaleimide was written by Lovely, Carl J.;Du, Hongwang;Dias, H. V. Rasika. And the article was included in Heterocycles in 2003.Safety of 4,5-Diiodo-1H-imidazole This article mentions the following:

The regioselective synthesis of 1-benzyl- and 1-methyl-4-vinylimidazole from 4,5-diiodoimidazole is described. Their Diels-Alder reactions with N-phenylmaleimide provide a variety of adducts, including the anticipated enamine and the corresponding aromatized isomer. However, addnl. products including ene adducts, a bis Diels-Alder adduct and oxidation products were isolated. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Safety of 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Assembly of a series of zinc coordination polymers based on 1,4-bis[2-(4-pyridyl)ethenyl]-2,3,5,6-tetramethylbenzene and 1,3-benzenedicarboxylate derivatives was written by Ge, Yu;Li, Ni-Ya;Ji, Xue-Ying;Wang, Jun-Feng;Liu, Dong;Tang, Xiao-Yan. And the article was included in CrystEngComm in 2014.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

Five new coordination polymers, namely, [Zn(1,3-BDC)(1,4-bpetmb)]_n (1), {[Zn₂(5-Cl-1,3-BDC)₂(1,4-bpetmb)₂]·MeCN}_n (2), [Zn(5-NO₂-1,3-BDC)(1,4-bpetmb)_0.5]_n (3), {[Zn(5-NH₂-1,3-BDC)(1,4-bpetmb)_0.5]·2H₂O}_n (4) and [Zn₂(μ-OH)(1,3,5-BTC)(1,4-bpetmb)]_n (5) have been synthesized under solvothermal conditions, based on the bis-pyridyl linker 1,4-bis[2-(4-pyridyl)ethenyl]-2,3,5,6-tetramethylbenzene (1,4-bpetmb) along with 1,3-benzenedicarboxylate (1,3-BDC) or its derivatives such as 5-chloro-1,3-benzenedicarboxylate (5-Cl-1,3-BDC), 5-nitro-1,3-benzenedicarboxylate (5-NO₂-1,3-BDC), 5-amino-1,3-benzenedicarboxylate (5-NH₂-1,3-BDC) and 1,3,5-benzenetricarboxylate (1,3,5-BTC). Compounds 1–5 have been characterized by elemental anal., IR spectroscopy, powder x-ray diffraction (PXRD) and unambiguously by single crystal X-ray diffraction anal. 1 And 2 feature the 2D (4,4) net. 3 Comprises an interlocked 3D framework, and the 3D framework is derived from the inclined interpenetration of the 2D (4,4) net. 4 Exhibits a thick 2D (3,4)-connected network with a Schlafli symbol of (6³)(6⁵·8). 5 Displays a 3D two-fold interpenetrating (3,5)-connected framework with the Schlafli symbol of (6³)(6⁷·8³). Thermal stability and solid-state photoluminescence properties of 1–5 were also investigated. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Room temperature charge-transfer phosphorescence from organic donor-acceptor Co-crystals was written by Garain, Swadhin;Ansari, Shagufi Naz;Kongasseri, Anju Ajayan;Chandra Garain, Bidhan;Pati, Swapan K.;George, Subi J.. And the article was included in Chemical Science in 2022.COA of Formula: C10H12I2 This article mentions the following:

Engineering the electronic excited state manifolds of organic mols. can give rise to various functional outcomes, including ambient triplet harvesting, that has received prodigious attention in the recent past. Herein, we introduce a modular, non-covalent approach to bias the entire excited state landscape of an organic mol. using tunable ‘through-space charge-transfer’ interactions with appropriate donors. Although charge-transfer (CT) donor-acceptor complexes have been extensively explored as functional and supramol. motifs in the realm of soft organic materials, they could not imprint their potentiality in the field of luminescent materials, and it still remains as a challenge. Thus, in the present study, we investigate the modulation of the excited state emission characteristics of a simple pyromellitic diimide derivative on complexation with appropriate donor mols. of varying electronic characteristics to demonstrate the selective harvesting of emission from its locally excited (LE) and CT singlet and triplet states. Remarkably, co-crystallization of the pyromellitic diimide with heavy-atom substituted and electron-rich aromatic donors leads to an unprecedented ambient CT phosphorescence with impressive efficiency and notable lifetime. Further, gradual minimizing of the electron-donating strength of the donors from 1,4-diiodo-2,3,5,6-tetramethylbenzene (or 1,2-diiodo-3,4,5,6-tetramethylbenzene) to 1,2-diiodo-4,5-dimethylbenzene and 1-bromo-4-iodobenzene modulates the source of ambient phosphorescence emission from the ³CT excited state to ³LE excited state. Through comprehensive spectroscopic, theor. studies, and single-crystal analyses, we elucidate the unparalleled role of intermol. donor-acceptor interactions to toggle between the emissive excited states and stabilize the triplet excitons. We envisage that the present study will be able to provide new and innovative dimensions to the existing mol. designs employed for triplet harvesting. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1COA of Formula: C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.COA of Formula: C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com