Tag: 300-400

Rational Design of a Novel Mononuclear Rhodium(II) Complex was written by Dixon, Felicia M.;Farrell, Joshua R.;Doan, Peter E.;Williamson, Amanda;Weinberger, Dana A.;Mirkin, Chad A.;Stern, Charlotte;Incarvito, Christopher D.;Liable-Sands, Louise M.;Zakharov, Lev N.;Rheingold, Arnold L.. And the article was included in Organometallics in 2002.Recommanded Product: 3268-21-1 This article mentions the following:

Reaction of rhodium(I) with a multidentate hemilabile bisphosphine ligand yields a two-legged piano-stool complexes I (X = O, n = 1,2; X = CH₂, n = 2) whose steric and electronic factors stabilize rhodium(II) upon chem. oxidation The inherent stabilizing properties of the ligand system allow for the first structural isolation of a novel mononuclear organometallic rhodium(II) complex in a two-legged piano-stool geometry. The crystal structures of I (X = O, CH₂, n = 2) and the oxidized product of I (X = CH₂, n = 2) were determined In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen was written by Riggs, Jennifer R.;Nagy, Mark;Elsner, Jan;Erdman, Paul;Cashion, Dan;Robinson, Dale;Harris, Roy;Huang, Dehua;Tehrani, Lida;Deyanat-Yazdi, Gordafaried;Narla, Rama Krishna;Peng, Xiaohui;Tran, Tam;Barnes, Leo;Miller, Terra;Katz, Jason;Tang, Yang;Chen, Ming;Moghaddam, Mehran F.;Bahmanyar, Sogole;Pagarigan, Barbra;Delker, Silvia;LeBrun, Laurie;Chamberlain, Philip P.;Calabrese, Andrew;Canan, Stacie S.;Leftheris, Katerina;Zhu, Dan;Boylan, John F.. And the article was included in Journal of Medicinal Chemistry in 2017.Computed Properties of C6H2Cl2IN3 This article mentions the following:

Triple neg. breast cancer (TNBC) remains a serious unmet medical need with discouragingly high relapse rates. The authors report here the synthesis and structure-activity relationship (SAR) of a novel series of 2,4,5-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines with potent activity against TNBC tumor cell lines. These compounds were discovered from a TNBC phenotypic screen and possess a unique dual inhibition profile targeting TTK (mitotic exit) and CLK2 (mRNA splicing). Design and optimization, driven with a TNBC tumor cell assay, identified potent and selective compounds with favorable in vitro and in vivo activity profiles and good iv PK properties. This cell-based driven SAR produced compounds with strong single agent in vivo efficacy in multiple TNBC xenograft models without significant body weight loss. These data supported the nomination of CC-671 (compound I) into IND-enabling studies as a single agent TNBC therapy. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1Computed Properties of C6H2Cl2IN3).

2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Computed Properties of C6H2Cl2IN3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Polyimides derived from 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl. 2. Synthesis and characterization of polyimides prepared from fluorinated benzenetetracarboxylic dianhydrides was written by Matsuura, Tohru;Ishizawa, Maki;Hasuda, Yoshinori;Nishi, Shiro. And the article was included in Macromolecules in 1992.Product Details of 3268-21-1 This article mentions the following:

Fluorinated rigid-rod polyimides are prepared by the polymerization of 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl (I) with 1,4-bis(trifluoromethyl)-2,3,5,6-benzenetetracarboxylic dianhydride (II), 1-(trifluoromethyl)-2,3,5,6-benzenetetracarboxylic dianhydride, or pyromellitic dianhydride (III). The dielec. constant, refractive index, and water absorption of the copolymers decrease with an increasing number of CF₃ side chains. The I–II polyimide, which has the highest F content, has the lowest dielec. constant of 2.6 at 1 MHz, the lowest refractive index of 1.490 at 589.3 nm, and the lowest water absorption of 0.38%. The coefficient of thermal expansion (CTE) of the copolymers increases with an increasing number of CF₃ side chains. I–III polyimide has a neg. CTE of -5 × 10^-6 °C^-1 by thermomech. anal. and a high polymer decomposition temperature of 613° measured for a 10% weight loss in a N atm. by TG. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Product Details of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective angiotensin II AT₂ receptor agonists: Benzamide structure-activity relationships was written by Wallinder, Charlotta;Botros, Milad;Rosenstroem, Ulrika;Guimond, Marie-Odile;Beaudry, Helene;Nyberg, Fred;Gallo-Payet, Nicole;Hallberg, Anders;Alterman, Mathias. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Recommanded Product: N,N-Diethyl-4-iodobenzamide This article mentions the following:

In the investigation of the structure-activity relationship of nonpeptide AT₂ receptor agonists, a series of substituted benzamide analogs of the selective nonpeptide AT₂ receptor agonist M024 have been synthesized. In a second series, the biphenyl scaffold was compared to the thienylphenyl scaffold and the impact of the iso-Bu substituent and its position on AT₁/AT₂ receptor selectivity was also investigated. Both series included several compounds with high affinity and selectivity for the AT₂ receptor. Three of the compounds were also proven to function as agonists at the AT₂ receptor, as deduced from a neurite outgrowth assay, conducted in NG108-15 cells. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Recommanded Product: N,N-Diethyl-4-iodobenzamide).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: N,N-Diethyl-4-iodobenzamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents was written by Tan, Hanyi;Liu, Yue;Gong, Chaochao;Zhang, Jiawei;Huang, Jian;Zhang, Qian. And the article was included in European Journal of Medicinal Chemistry in 2021.HPLC of Formula: 1012785-51-1 This article mentions the following:

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized according to the E-pharmacophores generated by docking a library of 667 fragments into the ATP pocket of the co-crystal complex of FAK and PF-562271 (PDB ID: 3BZ3). The 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine derivatives demonstrated excellent activity against FAK and the cell lines SMMC7721 and YY8103. 2-((2-((3-(Acetamidomethyl)phenyl)amino)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide (I) was selected for further bioactivity evaluations in vivo, including preliminary pharmacokinetic profiling in rats and toxicity assays in mice, and tumor growth inhibition studies in a xenograft tumor model. The results showed that I did not affect the body weight gain of the animals up to a dose of 200 mg/kg, and significantly inhibited tumor growth with a tumor growth inhibition rate of 78.6% compared with the neg. control group. Furthermore, phosphoantibody array analyses of a sample of the tumor suggested that I inhibited the malignant proliferation of hepatocellular carcinoma (HCC) cells through decreasing the phosphorylation in the FAK cascade. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1HPLC of Formula: 1012785-51-1).

2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.HPLC of Formula: 1012785-51-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New methods of imidazole functionalization – from imidazole to marine alkaloids was written by Du, Hongwang;He, Yong;Rasapalli, Sivappa;Lovely, Carl J.. And the article was included in Synlett in 2006.Application In Synthesis of 4,5-Diiodo-1H-imidazole This article mentions the following:

The pyrrole-imidazole family of marine alkaloids, the so-called oroidin natural products, exhibits an impressive diversity of structural motifs. The majority of these natural products contain one or more imidazole moieties intricately embedded within a polycyclic framework and thus present significant challenges to extant synthetic methods. Our approach to this problem has centered on the development of methods for the elaboration of simple imidazoles. This review describes the results of these efforts leading to the development of a variety of methods, including cycloadditions, oxidative and transition-metal-catalyzed reactions (e.g., with π-allylpalladium). In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Application In Synthesis of 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application In Synthesis of 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD) was written by Lagu, Bharat;Kluge, Arthur F.;Tozzo, Effie;Fredenburg, Ross;Bell, Eric L.;Goddeeris, Matthew M.;Dwyer, Peter;Basinski, Andrew;Senaiar, Ramesh S.;Jaleel, Mahaboobi;Tiwari, Nirbhay Kumar;Panigrahi, Sunil K.;Krishnamurthy, Narasimha Rao;Takahashi, Taisuke;Patane, Michael A.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Recommanded Product: 15813-09-9 This article mentions the following:

Arylheterocyclylmethylphenoxyalkanoic and -alkenoic acids such as I were prepared as selective activators of PPARδ for potential use in improving mitochondrial function and for treatment of Duchenne muscular dystrophy (DMD); the heterocyclyl moiety was designed to mimic the cis-amide conformation found in the crystal structure of a previously prepared PPARδ activator to the ligand binding domain of PPARδ. The activation of PPARδ, selectivities for PPARδ over PPARα and PPARγ, and pharmacokinetics (half-lives, clearance, and AUC) in mice were determined for the compounds I (MA-0204) was a potent, selective PPARδ modulator with good pharmacokinetic properties. I was tested in vivo in mice and in myoblasts isolated from a DMD patient; I altered the expression of PPARδ target genes and improved fatty acid oxidation, indicating that I may be useful for treating DMD. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed enantioselective C(sp²)-H arylation of ferrocenyl ketones enabled by a chiral transient directing group was written by Xu, Jiancong;Liu, Yang;Zhang, Jinling;Xu, Xiaohua;Jin, Zhong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Electric Literature of C11H14INO This article mentions the following:

Palladium-catalyzed enantioselective C(sp²)-H activation of ferrocenyl ketones is achieved through utilizing catalytic, inexpensive L-tert-leucine as a chiral transient directing group. The transformation allows rapid access to ferrocene scaffolds simultaneously possessing planar- and stereogenic central chirality, widely applied in the ferrocene-based chiral ligand families. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Electric Literature of C11H14INO).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C11H14INO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives was written by Morgentin, Remy;Barlaam, Bernard;Foote, Kevin;Hassall, Lorraine;Hawkins, Janet;Jones, Clifford D.;Le Griffon, Antoine;Peru, Aurelien;Ple, Patrick. And the article was included in Synthetic Communications in 2012.Category: iodides-buliding-blocks This article mentions the following:

We have developed two different approaches in parallel to rapidly access 2,4-bis(aminoaryl)pyridine compounds, e.g., I, from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis(aminoaryl)pyridine compounds In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Category: iodides-buliding-blocks).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis and evaluation of a ¹¹C-labelled angiotensin II AT₂ receptor ligand was written by Aberg, Ola;Stevens, Marc;Lindh, Jonas;Wallinder, Charlotta;Hall, Hakan;Monazzam, Azita;Larhed, Mats;Langstrom, Bengt. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2010.Safety of N,N-Diethyl-4-iodobenzamide This article mentions the following:

Three ¹¹C-radiolabeled high-affinity nonpeptide AT₂ receptor-selective ligands were synthesized, and one of these was evaluated as positron emission tomog. (PET) tracer. The labeling reaction was performed via Pd(0)-mediated aminocarbonylation of the aryl iodide substrate using ¹¹CO as the labeled precursor. As an example, starting with 10.0 GBq ¹¹CO, 1.10 GBq of the product N-butoxycarbonyl-3-[4-(N-benzyl-[¹¹C]carbamoyl)phenyl]-5-isobutylthiophene-2-sulfonamide was obtained in 36% decay-corrected radiochem. yield (from ¹¹CO), 42 min from end of bombardment with a specific activity of 110 GBq μmol^-1. The N-isopropyl-[¹¹C]carbamoyl analog (radiochem. purity >95%) was studied employing autoradiog., organ distribution, and small animal PET. In vitro autoradiog. showed specific binding in the pancreas and kidney. Organ distribution in rats revealed a high uptake in liver, intestine, kidney, and adrenals. Small animal PET showed rapid and reversible uptake in the kidneys followed by accumulation in the urinary bladder suggesting fast renal excretion of the tracer. In addition, high accumulation was also seen in the liver. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Safety of N,N-Diethyl-4-iodobenzamide).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of N,N-Diethyl-4-iodobenzamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com