Tag: 300-400

Five-State Rotary Nanoswitch was written by Gaikwad, Sudhakar;Schmittel, Michael. And the article was included in Journal of Organic Chemistry in 2017.Computed Properties of C10H12I2 This article mentions the following:

In our quest to develop artificial multistate devices, we synthesized the nanomech. switch 1 that is characterized by a tetrahedral core equipped with four pending arms. The rotary arm with its azaterpyridine terminal is intramolecularly coordinated to a zinc(II) porphyrin station that is the terminus of another arm in 1. The two other arms carry identical sterically shielded phenanthroline stations. The 2-fold alternate addition of a copper(I) ion and [1,10]-phenanthroline (1 equiv each) results in the formation of five different switching states (State Iâ†?State IIâ†?State IIIâ†?State IVâ†?State V â†?State I), which force the toggling arm to move back and forth between the zinc(II) porphyrin and phenanthroline stations separated by a distance of 25 Å. All switching states constitute clean single species, except for State III, and thus are fully characterized by spectroscopic methods and elemental anal. Finally, the initial state of nanoswitch was reset by addition of cyclam for complete removal of the copper(I) ions. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Computed Properties of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Computed Properties of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dissecting Porosity in Molecular Crystals: Influence of Geometry, Hydrogen Bonding, and [π···π] Stacking on the Solid-State Packing of Fluorinated Aromatics was written by Hashim, Mohamed I.;Le, Ha T. M.;Chen, Teng-Hao;Chen, Yu-Sheng;Daugulis, Olafs;Hsu, Chia-Wei;Jacobson, Allan J.;Kaveevivitchai, Watchareeya;Liang, Xiao;Makarenko, Tatyana;Miljanic, Ognjen S.;Popovs, Ilja;Tran, Hung Vu;Wang, Xiqu;Wu, Chia-Hua;Wu, Judy I.. And the article was included in Journal of the American Chemical Society in 2018.Electric Literature of C10H12I2 This article mentions the following:

Porous mol. crystals are an emerging class of porous materials that is unique in being built from discrete mols. rather than being polymeric in nature. In this study, we examined the effects of mol. structure of the precursors on the formation of porous solid-state structures with a series of 16 rigid aromatics The majority of these precursors possess pyrazole groups capable of hydrogen bonding, as well as electron-rich aromatics and electron-poor tetrafluorobenzene rings. These precursors were prepared using a combination of Pd- and Cu-catalyzed cross-couplings, careful manipulations of protecting groups on the nitrogen atoms, and solvothermal syntheses. Our study varied the geometry and dimensions of precursors, as well as the presence of groups capable of hydrogen bonding and [π···π] stacking. Thirteen derivatives were crystallog. characterized, and four of them were found to be porous with surface areas between 283 and 1821 m² g^-1. Common to these four porous structures were (a) rigid trigonal geometry, (b) [π···π] stacking of electron-poor tetrafluorobenzenes with electron-rich pyrazoles or tetrazoles, and (c) hydrogen bonding between the terminal heteroaromatic rings. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Electric Literature of C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides was written by Wu, Jiang;Liu, Yafei;Lu, Changhui;Shen, Qilong. And the article was included in Chemical Science in 2016.Formula: C6H2ClF3IN This article mentions the following:

Palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyrazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new led compounds for drug discovery. Likewise, aryl iodides were difluoromethylthiolated in high yields under a modified reaction condition. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Formula: C6H2ClF3IN).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C6H2ClF3IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed direct thioetherification of Alkyl Halides with S-Alkyl Butanethioate as Thiol transfer reagent was written by Tian, Qingqiang;Wang, Lili;Li, Yahui. And the article was included in Journal of Sulfur Chemistry in 2022.COA of Formula: C8H8BrI This article mentions the following:

A new and convenient copper-catalyzed synthesis of alkyl sulfides were accomplished using S-alkyl butanethioate as a thiol source. This catalytic protocol displayed a good functional groups tolerance and high efficiency. Both secondary and primary alkyl iodides were used in this procedure. In addition, this method featured operational simplicity and a wide substrate range, providing a complementary method for alkyl sulfide synthesis without requiring toxic thiols and noble metals. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9COA of Formula: C8H8BrI).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C8H8BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Octopolar Chromophores Based on Donor- and Acceptor-Substituted 1,3,5-Tris(phenylethynyl)benzenes: Impact of meta-Conjugation on the Molecular and Electronic Structure by Means of Spectroscopy and Theory was written by Moreno Oliva, Maria;Casado, Juan;Hennrich, Gunther;Lopez Navarrete, Juan T.. And the article was included in Journal of Physical Chemistry B in 2006.Application of 3268-21-1 This article mentions the following:

The mol. and electronic structures of all-meta-substituted phenylacetylene mesitylenes peripherally substituted with donor or acceptor (D-A) groups are studied. The impact of meta- and para-substitution patterns is also analyzed by employing Raman and optical spectroscopies in conjunction with theor. calculations Outer Ph rings display a partial quinoid character induced by two different motifs: (i) outer phenyls â†?triple bond charge transfer for the cases where these phenyls are substituted with electron-donors; (ii) double electron withdrawing effect in the mols. with the peripheral phenyls substituted with electron acceptors. A moderate tuning of the optical gap is observed in agreement with the partial blockade of π-electron conjugation exerted by the meta disposition. The orbital structure of the compounds partially preserves that of the mesitylene group showing extra-conjugation due to the addition of the arms, so that conjugation is not entirely obstructed but partially impeded in the ground electronic state (i.e., electron occupied orbitals). As for the excited states, the low-lying energy empty orbitals offer better conditions for full conjugation over the whole mol. scaffold. Interesting optical properties such as overlapping centers along the lowest energy optical excitations and enhanced optical transparency with importance for the application of these materials in optoelectronics were justified from the electronic structure. A greater degree of quinoidization, and more allowed π-electron delocalization, over the entire mol. is recognized in the case of linear phenylacetylenes substituting in para positions the central core. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Application of 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Metal Insertion in a Methylamine-Functionalized Zirconium Metal-Organic Framework for Enhanced Carbon Dioxide Capture was written by Gomora-Figueroa, A. Paulina;Mason, Jarad A.;Gonzalez, Miguel I.;Bloch, Eric D.;Meihaus, Katie R.. And the article was included in Inorganic Chemistry in 2017.SDS of cas: 3268-21-1 This article mentions the following:

The reaction of ZrCl₄ with 2′,3′,5′,6′-tetramethylamino-p-terphenyl-4,4”-dicarboxylic acid (H₂tpdc-4CH₂NH₂·3HCl) in the presence of NaF affords Zr₆O₄(OH)_2.1F_1.9(tpdc-4CH₂NH₂·3HCl)₆ (1), which is a new member of the Zr₆O₄(OH)₄(dicarboxylate linker)₁₂ or UiO-68 family, and exhibits high porosity with BET and Langmuir surface areas of 1910 m²/g and 2220 m²/g, resp. Remarkably, fluoride ion incorporation in the zirconium clusters results in increased thermal stability, marking the first example of enhancement in the stability of a UiO framework by this defect-restoration approach. Although material 1 features four alkylamine groups on each organic linker, the framework does not exhibit the high CO₂ uptake that would be expected for reaction between CO₂ and the amine groups to form carbamic acid or ammonium carbamate species. The absence of strong CO₂ adsorption can likely be attributed to protonation at some of the amine sites and the presence of counterions. Indeed, exposure of material 1 to acetonitrile solutions of the organic bases 1,8-bis(dimethylamino)naphthalene (DMAN) or trimethylamine, affords a partially deprotonated material, which exhibits enhanced CO₂ uptake. Exposure of basic amine sites also facilitates the postsynthetic chelation of copper(I) ([Cu(MeCN)₄]·CF₃SO₃) to yield material 2 with an enhanced CO₂ uptake of 4% at 0.15 bar, which is double that of the parent framework 1. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1SDS of cas: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.SDS of cas: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1 Agonists with Reduced Effect on Heart Rate was written by Hamada, Maiko;Nakamura, Mitsuharu;Kiuchi, Masatoshi;Marukawa, Kaoru;Tomatsu, Ayumi;Shimano, Kyoko;Sato, Noriko;Sugahara, Kunio;Asayama, Mahoko;Takagi, Kan;Adachi, Kunitomo. And the article was included in Journal of Medicinal Chemistry in 2010.Synthetic Route of C8H8BrI This article mentions the following:

A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate receptor-1 (S1P₁) receptor agonists with potent immunomodulatory activity accompanied by little or no effect on heart rate. Many of the synthesized compounds sufficiently decreased the number of peripheral blood lymphocytes. Some of the phosphates had potent agonism at S1P₁ but no agonism at S1P₃, which had been reported to be a receptor responsible for heart rate reduction Although high S1P₁/S1P₃ selectivity was considered to be favorable to reduce the effect on heart rate, almost all the phosphates showed a remarkable heart rate lowering effect in vivo. The results suggest that other factors in addition to S1P₃ agonism should be responsible for the heart rate reduction caused by S1P₁ agonists. Only 2-amino-2-[2-[2′-fluoro-4′-(4-methylphenylthio)biphenyl-4-yl]ethyl]propane-1,3-diol (6d) was identified as a desired S1P₁ receptor agonist having both the immunomodulatory activity and an attenuated effect on heart rate by a unique screening flow using in vivo evaluating systems primarily. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Synthetic Route of C8H8BrI).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Synthetic Route of C8H8BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dense Iodine-Rich Compounds with Low Detonation Pressures as Biocidal Agents was written by He, Chunlin;Zhang, Jiaheng;Shreeve, Jean’ne M.. And the article was included in Chemistry – A European Journal in 2013.Product Details of 15813-09-9 This article mentions the following:

Fifteen iodo compounds and six iodyl compounds with an iodine content between 45.3-89.0 % were prepared The mono, di, and triiodyl compounds were obtained from the corresponding iodo compound by employing Oxone. All the compounds were characterized by IR, ¹H and ¹³C NMR, elemental anal., and differential scanning calorimetry (DSC). The impact sensitivity was measured by using BAM (Bundesamt fuer Materialforschung) methodol. Based on the calculated heats of formation and exptl. densities, the detonation properties and detonation products were predicted by employing Cheetah 6.0. A total percentage of iodine-containing species in weight % (I₂, HI, and I in gas phase) ranged from 46.7 (21)-88.94 % (11) was found in the detonation products. The high concentration and easy accessibility of iodine and/or iodine-containing species is very important in developing materials suitable as Agent Defeat Weapons (ADWs). In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Product Details of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Product Details of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

3α-Hydroxy-3β-(phenylethynyl)-5β-pregnan-20-ones: Synthesis and Pharmacological Activity of Neuroactive Steroids with High Affinity for GABA_A Receptors was written by Upasani, Ravindra B.;Yang, Kevin C.;Acosta-Burruel, Manuel;Konkoy, Chris S.;McLellan, James A.;Woodward, Richard M.;Lan, Nancy C.;Carter, Richard B.;Hawkinson, Jon E.. And the article was included in Journal of Medicinal Chemistry in 1997.Application of 77350-52-8 This article mentions the following:

Neuroactive steroids that allosterically modulate GABA_A receptors have potential uses as anticonvulsants, anxiolytics, and sedative-hypnotic agents. Recently, a series of pregnanes substituted with simple alkyl groups at the 3β-position were synthesized and found to be active in vitro. The present report describes the synthesis of a series of substituted 3α-hydroxy-3β-(phenylethynyl)pregnan-20-ones I [R = 4-MeO, 4-Cl, 4-Me₂N, CN-4, CONH₂-4, 4-Ph, 4-HO, 4-O₂N, 2-MeO, 3,4-(MeO)₂, 3,4-OCH₂O, 2-HO, 3-HO, 4-Me, 4-H₂N, 4-CF₃, 4-Ac, 4-EtO₂C, CHO-4, CONEt₂-4, COPh-4; R¹ = Me; R = Ac, CO₂Et-4, R¹ = H] and their in vitro structure-activity relationship determined by their potency for inhibition of [³⁵S]TBPS binding in rat brain membranes. Appropriate substitution of the Ph group results in ligands with particularly high affinity for the neuroactive steroid site on GABA_A receptors [e.g., I (R = 4-Ac; R¹ = Me), IC₅₀ 10 nM]. The potency of selected steroids was confirmed electrophysiol. in oocytes expressing cloned human GABA_A α1β2γ2L receptors [e.g., I (R = 4-Ac; R¹ = Me), EC₅₀ 6.6 nM]. Consistent with their in vitro activity, some of the 3β-(phenylethynyl)-substituted steroids displayed anticonvulsant activity in the pentylenetetrazol (PTZ) and maximal electroshock (MES) tests following i.p. administration in mice. Notably, the 3β-[(4-acetylphenyl)ethynyl]-19-nor derivative I (R = Ac, R¹ = H) provided an attractive anticonvulsant profile (PTZ and MES ED₅₀ values of 2.8 and 9.2 mg/kg, resp.). A new pharmacophore for the neuroactive steroid site of GABA_A receptors is proposed based upon the high affinity of certain substituted 3β-(phenylethynyl) steroids. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Application of 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application of 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of soluble, linear trisphenanthrolines was written by Schmittel, Michael;Michel, Christoph;Wiegrefe, Andreas. And the article was included in Synthesis in 2005.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

The preparation of several soluble, linear tris(phenanthroline) derivatives is described. The ligands are designed along the HETPHEN concept as precursors for heteroleptic bis(phenanthroline) metal ion complexes. Hence, they are important building blocks for various supramol. structures, such as nanogrids, nanoladders and nanotubes. An example compound thus prepared was a tris(phenanthroline) (I). In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com