Tag: 300-400

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) was written by Lucas-Hourani, Marianne;Munier-Lehmann, Helene;El Mazouni, Farah;Malmquist, Nicholas A.;Harpon, Jane;Coutant, Eloi P.;Guillou, Sandrine;Helynck, Olivier;Noel, Anne;Scherf, Artur;Phillips, Margaret A.;Tangy, Frederic;Vidalain, Pierre-Olivier;Janin, Yves L.. And the article was included in Journal of Medicinal Chemistry in 2015.Recommanded Product: 4,5-Diiodo-1H-imidazole This article mentions the following:

Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bearing analogs. As in our previous report, the structure-activity study of this series of human DHODH inhibitors was based on a phenotypic assay measuring measles virus replication. Among other inhibitors, this round of syntheses and biol. evaluation iteration led to the highly active 5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-3-fluoropyridine (I). Inhibition of DHODH by this compoundI was confirmed in an array of in vitro assays, including enzymic tests and cell-based assays for viral replication and cellular growth. I was found to be more active than the known inhibitors of DHODH, brequinar and teriflunomide, thus opening perspectives for its use as a tool or for the design of an original series of immunosuppressive agent. Moreover, because other series of inhibitors of human DHODH have been found to also affect Plasmodium falciparum DHODH, all the compounds were assayed for their effect on P. falciparum growth. However, the modest in vitro inhibition solely observed for two compounds did not correlate with their inhibition of P. falciparum DHODH. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 4,5-Diiodo-1H-imidazole).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 4,5-Diiodo-1H-imidazole

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New strategies in the synthesis of regioselectively trifluoromethyl- and trifluoromethoxy-substituted arenes as building blocks for biologically active molecules was written by Leconte, Stephane;Ruzziconi, Renzo. And the article was included in Journal of Fluorine Chemistry in 2002.Reference of 505084-55-9 This article mentions the following:

Regioisomerically pure trifluoromethyl- and trifluoromethoxy-substituted aromatic and heteroaromatic aldehydes and carboxylic acids are valuable building blocks for the synthesis of biol. active mols. They have been prepared by employing modern organometallic methods. On this basis, a novel access to 2,3-dihydro-5-(trifluoromethoxy)indole was developed which represents an intriguing example of how organometallic and radical chem. can fecundate each other. Iodination of [4-(trifluoromethoxy)phenyl]carbamic acid 1,1-dimethylethyl ester gave [2-Iodo-4-(trifluoromethoxy)phenyl]carbamic acid 1,1-dimethylethyl ester. Allylation of the latter gave [2-iodo-5-(trifluoromethoxy)phenyl]-2-propenylcarbamic acid 1,1-dimethylethyl ester which was cyclized to give 2,3-dihydro-3-methyl-5-(trifluoromethoxy)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Reference of 505084-55-9).

2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Reference of 505084-55-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Solid-state organic reactions proceeding by pulverization: oxidation and halogenation with iodosobenzene and inorganic solid-supports was written by Sohmiya, Hajime;Kimura, Takahide;Fujita, Mitsue;Ando, Takashi. And the article was included in Tetrahedron in 1998.Quality Control of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

Pulverization-activation method was employed to accelerate solid-state organic reactions. Crushing and grinding of solid mixtures of hydrogen halide-treated silica gels, iodosobenzene, and organic substrates in the absence of a solvent brought about smooth and rapid reactions to give halogenated and/or oxidized products in good yields. Various sulfides were smoothly converted to sulfonyl chlorides in one step in excellent yields. The surface of silica gel activated by pulverization serves as a reaction field on which reagent mols. can effectively encounter with each other. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Quality Control of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Quality Control of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Four-Component Supramolecular Nanorotors was written by Samanta, Soumen K.;Schmittel, Michael. And the article was included in Journal of the American Chemical Society in 2013.Formula: C10H12I2 This article mentions the following:

A family of supramol. four-component nanorotors was quant. self-assembled from two different Zn(II) porphyrins: one representing the stator and the other the rotator with DABCO as an interconnecting axle and Cu(I) ions. Rotational spinning in ROT-1′ occurs at 97,000 s^-1 at 25鎺?but is virtually stopped at -75鎺? The activation vs. binding data suggest that spinning is an intrasupramol. process occurring to >99.9% without dissociation Addition and removal of two further equiv of Cu⁺ reversibly switches the mode of the stochastic rotation between pure 180鎺?and mixed 90鎺?180鎺?steps and reversibly regulates the speed between 97,000 and 閳?0,000 s^-1. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Formula: C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Formula: C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Domino Approach of Heck Coupling for the Synthesis of 灏?Trifluoromethylstyrenes was written by Prakash, G. K. Surya;Krishnan, Hema S.;Jog, Parag V.;Iyer, Anjali P.;Olah, George A.. And the article was included in Organic Letters in 2012.HPLC of Formula: 3268-21-1 This article mentions the following:

A domino approach of Heck coupling was used to synthesize 灏?trifluoromethylstyrene derivatives from iodoarenes and 1-iodo-3,3,3-trifluoropropane in moderate to good yields. This method avoids the use of low-boiling, gaseous reagents such as 3,3,3-trifluoropropene, and additives and phosphines in the catalytic system. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1HPLC of Formula: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.HPLC of Formula: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Azoles. Part 4. Nucleophilic substitution reactions of haloimidazoles was written by Iddon, Brian;Khan, Nazir;Lim, Bee Lan. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Synthetic Route of C3H2I2N2 This article mentions the following:

A number of N-protected derivatives of 2,4,5-tribromoimidazole, 4-bromo-5-nitroimidazole, and 2,4-dibromo-5-nitroimidazole were prepared by standard procedures and treated with various nucleophiles. Whereas 2,4,5-tribromo (and tri-iodo)imidazole reacted with PhSNa to give 4,5-dihaloimidazoles, 1-protected derivatives of 2,4,5-tribromoimidazole reacted with RSNa (R = Et, Pr, Ph, PhCH₂) in Me₂CHOH, by displacement of the 2-bromine atom. 1-Benzyl-5-bromo-4-nitroimidazole, 2-(5-bromo-4-nitroimidazol-1-yl) acetate, and 5-bromo-4-nitro-1-phenacylimidazole (I) reacted by displacement of the 5-bromine atom. The product arising from reaction of I with HSCH₂CO₂Et in EtOH in the presence of base, cyclized to give imidazothiazine II. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Synthetic Route of C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

One-Pot Preparation of Alkyl Iodides from Esters by Indium-Catalyzed Reductive Cleavage of a Carbon-Oxygen Bond was written by Sakai, Norio;Matsushita, Yohei;Konakahara, Takeo;Ogiwara, Yohei;Hirano, Keisuke. And the article was included in European Journal of Organic Chemistry in 2015.Category: iodides-buliding-blocks This article mentions the following:

The indium-catalyzed reductive iodination of aliphatic and aromatic esters with iodine and 1,1,3,3-tetramethyldisiloxane (TMDS) was described. The reducing procedure accommodates a variety of esters, including esters containing alkyl groups, halogens, a hydroxy group, a thioether, and an alkene moiety. This procedure was applied to the cleavage of carbon-oxygen bonds in acrylate polymers. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Category: iodides-buliding-blocks).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Investigation was written by Lee, Yeosan;Baek, Seung-yeol;Park, Jinyoung;Kim, Seoung-Tae;Tussupbayev, Samat;Kim, Jeongho;Baik, Mu-Hyun;Cho, Seung Hwan. And the article was included in Journal of the American Chemical Society in 2017.HPLC of Formula: 77350-52-8 This article mentions the following:

A new transition-metal-free borylation of aryl and vinyl halides using 1,1-bis[(pinacolato)boryl]alkanes as boron sources is described. In this transformation one of the boron groups from 1,1-bis[(pinacolato)boryl]alkanes is selectively transferred to aryl and vinyl halides in the presence of sodium tert-butoxide as the only activator to form organoboronate esters. Under the developed borylation conditions, a broad range of organohalides are borylated with excellent chemoselectivity and functional group compatibility, thus offering a rare example of a transition-metal-free borylation protocol. Exptl. and theor. studies have been performed to elucidate the reaction mechanism, revealing the unusual formation of Lewis acid/base adduct between organohalides and 浼?borylcarbanion, generated in situ from the reaction of 1,1-bis[(pinacolato)boryl]alkanes with an alkoxide base, to facilitate the borylation reactions. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8HPLC of Formula: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photo-induced and electronic properties of soluble rigid-rod polyimides was written by Tomikawa, Masao. And the article was included in Recent Research Developments in Polymer Science in 1998.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

A series of fluoroalkyl-substituted pyromellitic dianhydrides were synthesized from 1,2,4,5-tetramethyl-benzene (durene). Soluble rigid-rod polyimides were obtained from the dianhydrides and 4,4′-Diamino-2,2′-bis(trifluoromethyl)biphenyl (PFMB) in phenolic solvents in the presence of isoquinoline catalyst. The polyimides are soluble in N-methyl-2-pyrrolidone (NMP), N,N-dimethylacetamide (DMAc), m-cresol, and other polar solvents, in spite of their rigid-rod structure. UV irradiation induced color changes of the polyimide solutions A new absorption band appeared in the 700 nm region and an ESR signal emerged upon UV-irradiation which are attributed to the anion radical of the diimide moiety in the polyimide, as deduced from the hyperfine structure of the ESR signal. The same radical was detected by electrochem. confirming that the radical was generated by photoinduced charge transfer reaction. The UV-irradiation also causes a decrease in the solution viscosity and this change is reversible. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts was written by Caspers, Lucien D.;Spils, Julian;Damrath, Mattis;Lork, Enno;Nachtsheim, Boris J.. And the article was included in Journal of Organic Chemistry in 2020.SDS of cas: 503821-94-1 This article mentions the following:

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates, e.g., I, are described. Strong Bronsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alc. derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and d. functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-iodobenzoic acid (cas: 503821-94-1SDS of cas: 503821-94-1).

3-Bromo-2-iodobenzoic acid (cas: 503821-94-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 503821-94-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com