Iodides-buliding-blocks

364-77-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 364-77-2, name is 2-Iodo-5-fluoronitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

STEP 1. Methyl trans-(4-fluoro-2-nitro)cinnamate The title compound was prepared according to the procedure described in step 1 of Example 24 from 3-fluoro-6-iodonitrobenzene and methyl acrylate. 1H-NMR (CDCl3) delta: 8.67 (1H, d, 15.8Hz), 7.78 (1H, dd, 8.07Hz, 2.65Hz), 7.68-7.63 (2H, m), 6.34 (1H, d, 15.8Hz), 3.84 (3H, s).

The synthetic route of 2-Iodo-5-fluoronitrobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; EP1065206; (2001); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The chemical industry reduces the impact on the environment during synthesis 645-00-1, name is 1-Iodo-3-nitrobenzene, I believe this compound will play a more active role in future production and life. 645-00-1

General procedure: For example, synthesis of 1,2-diphenylethyne, 3a. To an oven-dried 5 mL microwave vessel was added Pd(PPh3)2Cl2 (3.5 mg, 0.005 mmol, 2 mol %) and CuI (1.9 mg, 0.01 mmol, 4 mol %). The vessel was then capped and purged with N2 before addition of Cyrene (0.5 mL, 0.5 M), Et3N (38 muL, 0.275 mmol, 1.1 equiv), iodobenzene (27.9 muL, 0.25 mmol, 1 equiv), and phenylacetylene (28.8 muL, 0.263 mmol, 1.05 equiv). The reaction mixture was heated to 30 C and maintained at this temperature with stirring for 1 h before the vessel was vented, and decapped. The solution was then diluted with EtOAc (10 mL), and washed with water (2¡Á 20 mL) and brine (2 ¡Á 20 mL). The organics were then passed through a hydrophobic frit and concentrated under reduced pressure to give a yellow oil, which was purified by flash chromatography (silica gel, 0-5% Et2O in petroleum ether) to afford the title compound as a white solid (44.5 mg, quant.).

The chemical industry reduces the impact on the environment during synthesis 645-00-1. I believe this compound will play a more active role in future production and life.

Reference:
Article; Wilson, Kirsty L.; Kennedy, Alan R.; Murray, Jane; Greatrex, Ben; Jamieson, Craig; Watson, Allan J. B.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2005 – 2011;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

19230-28-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19230-28-5 name is 1,3-Dichloro-2-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under an argon atmosphere,2- [3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) biphenyl-5-yl] -4,6- diphenyl- 1,3,5-triazine 2.0 g, 3.9 mmol),2,6-Dichloro-1-iodobenzene (1.2 g, 4.3 mmol),And bis (triphenylphosphine) palladium dichloride(55 mg, 78 mumol)Was suspended in THF (39 mL)To this was added 3 M potassium carbonate aqueous solution (2.6 mL).The mixture was stirred at 80 C. for 30 hours and then allowed to cool to room temperature. Water (30 mL) and methanol (30 mL) were added to the reaction solution, and the resulting precipitate was separated by filtration and washed with water, methanol and hexane.By recrystallizing the obtained solid from toluene,A white solid (1.3 g, 2.5 mmol, 64%) of the intermediate 2- (2 ‘, 6’-dichloro-5-phenylbiphenyl-3-yl) -4,6- diphenyl- ) Was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dichloro-2-iodobenzene, and friends who are interested can also refer to it.

Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; AIHARA, HIDENORI; SHONO, TOMOHIRO; UCHIDA, NAOKI; NOMURA, KEISUKE; HATTORI, KAZUKI; (90 pag.)JP2018/95562; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

3032-81-3, Adding a certain compound to certain chemical reactions, such as: 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3032-81-3.

To a solution of 3,5-dichloro iodobenzene (1.8 g, 6.6 mmol) in diethyl ether (20 ml) cooled to -78¡ã C. is added n-BuLi (2.8 ml of a 2.5 M solution in hexane, 6.8 mmol). The reaction mixture is stirred at -78¡ã C. for 10 min, allowed to warm to 25¡ã C. and added in three portions to a solution of N-t-butoxycarbonyl-3-ketopiperidine (598 mg, 3.01 mmol) in diethyl ether (10 ml) cooled to 0¡ã C. The reaction mixture is stirred at 25¡ã C. for 30 min. The reaction mixture is diluted with ethyl acetate, washed with 1 N KHSO4, water and brine, dried over sodium sulfate and concentrated in vacuo. The crude product is purified by flash chromatography (silica gel, 30percent to 50percent ethyl acetate in hexane) to give N-t-butoxycarbonyl-3-(3,4-dichlorophenyl)-3-hydroxy piperidine (150 mg).

According to the analysis of related databases, 3032-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nantermet, Philippe G.; Barrow, James C.; Selnick, Harold G.; US2001/44454; (2001); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A common compound: 628-21-7, name is 1,4-Diiodobutane, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 628-21-7

Preparatory Example 7 Spiro[cyclopentane-1,3′-indolin]-2′-one n-Butyl lithium (2.5 M in hexanes, 4.2 mL, 0.5 mmol) was added dropwise to a suspension of indolinone (0.665 mg, 5 mmol) and TMEDA (1.5 mL, 10 mmol) in THF (20 mL) at -78 C. in a dried flask under nitrogen. After 1 hour at -78 C., 1,4-diiodobutane (3.3 mL, 25 mmol) was added dropwise and the mixture was allowed to slowly warm to rt. After 12 hours at rt, saturated aqueous ammonium chloride was added to the mixture and this mixture was extracted with EtOAc. The combined organic phases were washed with water, brine, dried over magnesium sulphate, filtered and concentrated in vacuo. Chromatography on silica (10-30% EtOAc in isohexane) gave isolation of the desired compound as a pale pink solid (393 mg, 2.1 mmol, 42%). 1H NMR (400 MHz): delta 1.90 (m, 2H), 2.03 (m, 2H), 2.10 (m, 2H), 2.21 (m, 2H), 6.94 (m, 1H), 7.04 (m, 1H), 7.20 (m, 2H), 8.75 (bs, 1H). LC/MS 188 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 628-21-7, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; re: Viral Ltd; Cockerill, Stuart; Pilkington, Christopher; Lumley, James; Angell, Richard; Mathews, Neil; US2014/308282; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding some certain compound to certain chemical reactions, such as: 20691-72-9, name is 4-Iodo-2-nitroaniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20691-72-9. 20691-72-9

General procedure: Ra/Ni (0.4-0.5 g) was added in small portions to a stirred solution of 6.5 mmol of the required nitro compound (4-11) in 12 mL EtOH, 12 mL 1,2-dichloroethane and 2 mL (20 mmol) hydrazine hydrate at 30 C. After completion of the Ra/Ni addition, the mixture was heated in a water bath (50 C, 60 min) and filtered through celite. The filtrate was evaporated in vacuo and crude product used for further syntheses.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Iodo-2-nitroaniline.

Reference:
Article; Vasic, Vesna P.; Penjisevic, Jelena Z.; Novakovic, Irena T.; Sukalovic, Vladimir V.; Andric, Deana B.; Kostic-Rajacic, Sladana V.; Journal of the Serbian Chemical Society; vol. 79; 3; (2014); p. 277 – 282;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 112671-42-8

(3) Add (100mmol) M2 to the reaction flask32.6g (100mmol) of 2-iodo-5-bromonitrobenzene,(1%) Pd (PPh3) 4,40g (300mmol) sodium carbonate,Toluene (800mL), ethanol (200mL)And water (200mL),Heated to reflux, reacted for 8h, the reaction was completed;The reaction solution was extracted with ethyl acetate, and the organic phase was concentrated.A yellow solid M3 was obtained;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112671-42-8, its application will become more common.

Reference:
Patent; Yantai Xianhua Chemical Technology Co., Ltd.; Xing Qifeng; Feng Peichuan; Chen Yue; Hu Lingfeng; Chen Yili; (28 pag.)CN110698458; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

124700-41-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 124700-41-0, name is 2-Fluoro-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

PREPARATION 8 Ethyl 3-(2-fluoro-5-iodophenyl)-3-oxopropanoate To a stirred solution of 5.32 g of 2-fluoro-5-iodobenzoic acid from Preparation No. 7 in 20 mL of THF, under argon, is added 3.9 g of carbonyldiimidazole. In a separate flask, 2.8 mL of chlorotrimethylsilane is added to a mixture of 3.74 g of potassium ethyl malonate in 20 mL of acetonitrile. The mixture is stirred under argon for 18 h, then cooled to 0 C. for the dropwise addition of 6.6 mL of DBU. The mixture is stirred for 3 h at 0 C., then the solution of acyl imidazolide prepared above is added via cannula. After 2 hours, the mixture is partitioned between ether and excess dilute HCl, and the organic phase is washed with dilute HCl and brine and dried (MgSO4). Removal of the solvent under reduced pressure left a colorless oil, which is flash chromatographed on silica using 10% ethyl acetate in hexane to provide 5.07 g of the title compound as dense pinkish prisms. Physical properties as follows: 1H NMR (CDCl3) delta 1.34, 4.27, 5.82, 6.89, 7.7, 8.2 ppm; IR 1624, 1485, 1419, 1245, 1193, 1070, 1028, 813 cm-1.

The synthetic route of 124700-41-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pharmacia & Upjohn Company; US6248736; (2001); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 629-09-4 name is 1,6-Diiodohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 629-09-4

To a suspension of potassium 1,3-dioxoisoindolin-2-ide (5 g, 27 mmol) in DMF (250 mL) was added 1,6-diiodohexane (22.83 g, 67.5 mmol) dropwise and heated at 85 C for 2 h. The reaction mixture was monitored with LCMS. The reaction mixture was diluted with cold water and extracted with diethyl ether (2×300 mL), and the combined organic layer was washed with water (3×250 mL) and brine (250 mL). The organic layer dried over sodium sulfate and concentrated under reduced pressure to obtain a crude product which was purified by column chromatography with 10% EtOAc in hexane as eluent to afford 8.5 g of 2-(6- iodohexyl)isoindoline- 1 ,3-dione.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,6-Diiodohexane, and friends who are interested can also refer to it.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; MCCULLAGH, Emma; BERNALES, Sebastian; HUNG, David; (415 pag.)WO2017/19822; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The chemical industry reduces the impact on the environment during synthesis 77317-55-6, name is Methyl 2-amino-5-iodobenzoate, I believe this compound will play a more active role in future production and life. 77317-55-6

Example 23 This example describes the synthesis of 2-iodo-9-trifluoromethyl-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one. A solution of methyl succinyl chloride (3011 mg, 20 mmol) in toluene (10 mL) was added dropwise by means of a dropping funnel to a mixture of 2-amino-5-iodobenzoic acid methyl ester (4156 mg, 15 mmol), pyridine (1.7 mL), and toluene (10 mL) with stirring and cooling. The resulting suspension was refluxed for 3 hours. After cooling to room temperature, water (15 mL) was added. The organic layer was separated and washed successively with 10% hydrochloric acid (5 mL) and 5% aqueous sodium carbonate solution (5 mL). Subsequently, the organic layer was dried over sodium sulfate and evaporated. The residue was crystallized from ethanol to yield 72% colorless crystals of precursor 5-iodo-2-[(4-methoxy-1,4-dioxobutyl)amino]-benzoic acid methyl ester, mp. 133 C.; ir (KBr): 3250 (NH), 1730/1720/1680 (C=O); 1H-nmr (DMSO-d6, 400 MHz): delta (ppm)=2.59-2.69 (m, AA’BB’, 4H, CH2-CH2), 3.60 (s, 3H, OCH3), 3.85 (s, 3H, OCH3), 7.91 (dd, 1H, 8.7/2.0 Hz), 7.99 (d, 1H, 8.7 Hz), 8.14 (d, 1H, 2.0 Hz), 10.53 (s, 1H, NH); 13C-nmr (DMSO-d6, 100.6 MHz): delta (ppm)=28.3, 31.4, 51.3, 52.5, 86.3, 120.1, 123.2, 138.3, 138.8, 141.9, 166.1, 170.1, 172.5; C13HI4INO5 (391.17); Calcd. C 39.9, H 3.6, N 3.6,1 32.4; Found C 39.9, H 3.7, N 3.6,1 32.4.

The chemical industry reduces the impact on the environment during synthesis 77317-55-6. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Zaharevitz, Daniel W.; Gussio, Rick P.; Jalluri, Ravi K.; Sausville, Edward A.; Kunick, Conrad; Meijer, Laurent; US2002/42412; (2002); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com