Category: iodides-buliding-blocks

Synthesis of Electron-Deficient Heteroaromatic 1,3-Substituted Cyclobutyls via Zinc Insertion/Negishi Coupling Sequence under Batch and Automated Flow Conditions was written by Tissot, Matthieu;Body, Nathalie;Petit, Sylvain;Claessens, Jehan;Genicot, Christophe;Pasau, Patrick. And the article was included in Organic Letters in 2018.Recommanded Product: 395082-55-0 This article mentions the following:

Synthesis of 1,3-substituted cyclobutyls enabled by zinc insertion into functionalized iodocyclobutyl derivatives followed by Negishi coupling with halo-heteroaromatics is reported. Two distinct sets of conditions were developed; the first involved a two-step batch protocol using activated Rieke zinc, and the second involved a multistep continuous flow process. Both methods showed complementarity and allowed for rapid access to these medicinally relevant motifs, the possibility of scaling up, and automation for library synthesis. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-iodopyrimidine (cas: 395082-55-0Recommanded Product: 395082-55-0).

2-Chloro-4-iodopyrimidine (cas: 395082-55-0) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 395082-55-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stereospecific synthesis of trans-5,6-dihydropyridinones was written by Chou, Shang-Shing P.;Yang, Tsung-Han;Wu, Wan-Shiuan;Chiu, Tzu-Han. And the article was included in Synthesis in 2011.Recommanded Product: 1-Chloro-4-iodobutane This article mentions the following:

An efficient synthesis of trans-5,6-dihydropyridinones bearing a heteroatom (Br, OH) at C(5) was achieved. The formal synthesis of (±)-epiquinamide and (±)-homopumiliotoxin 223G was also accomplished through the formation of (±)-trans-1-hydroxyquinolizidin-4-one. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Solid-phase total synthesis of scytalidamide A was written by Gu, Wenxin;Silverman, Richard B.. And the article was included in Journal of Organic Chemistry in 2003.Safety of 3-Iodo-4-methoxybenzaldehyde This article mentions the following:

The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different linker resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the preceding paper in this issue (Tan, L. T. at al.). In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Safety of 3-Iodo-4-methoxybenzaldehyde).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Safety of 3-Iodo-4-methoxybenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic Enantioselective Approach to the Stereodivergent Synthesis of (+)-Lasubines I and II was written by Garcia Mancheno, Olga;Gomez Arrayas, Ramon;Adrio, Javier;Carretero, Juan C.. And the article was included in Journal of Organic Chemistry in 2007.Related Products of 10297-05-9 This article mentions the following:

A concise and efficient approach to the stereodivergent synthesis of (+)-lasubines I (I) and II (II) is described. The key common intermediate is a chiral N-sulfonyl 2,3-dihydropyridone obtained by a novel Cu-catalyzed asym. formal aza-Diels-Alder reaction between N-tosyl aldimines and Danishefsky’s diene. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Related Products of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Related Products of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

m-Iodosylbenzoic acid – a convenient recyclable reagent for highly efficient aromatic iodinations was written by Kirschning, Andreas;Yusubov, Mekhman S.;Yusubova, Roza Y.;Chi, Ki-Whan;Park, Joo Y.. And the article was included in Beilstein Journal of Organic Chemistry in 2007.Category: iodides-buliding-blocks This article mentions the following:

M-Iodosylbenzoic acid is used to perform iodination of arenes in the presence of iodine at room temperature in acetonitrile. Separation of pure products is conveniently achieved by scavenging any aryl iodide by ion exchange with IRA-900 (hydroxide form). The reduced form of the reagent, m-iodobenzoic acid, can be easily recovered from the ion exchange resin or from the basic aqueous solution by simple acidification with HCl. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Category: iodides-buliding-blocks).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Direct Bis-Arylation of Cyclobutanecarboxamide via Double C-H Activation: An Auxiliary-Aided Diastereoselective Pd-Catalyzed Access to Trisubstituted Cyclobutane Scaffolds Having Three Contiguous Stereocenters and an All-cis Stereochemistry [Erratum to document cited in CA160:007081] was written by Parella, Ramarao;Gopalakrishnan, Bojan;Babu, Srinivasarao Arulananda. And the article was included in Journal of Organic Chemistry in 2014.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

Upon further anal. the authors discovered the proton NMR processing software was set to use fewer significant digits, which was not realized during data processing; the reprocessed NMR spectra are provided and the conclusions are unaffected. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Recommanded Product: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Isolation of macrocyclic metacyclophanes from the attempted synthesis of [7.0]metacyclophanes of the myricanone series by Thorpe-Ziegler intramolecular cyclization of diaryls substituted by ω-cyanoalkyl chains was written by Dansou, Benedicte;Pichon, Christophe;Dhal, Robert;Brown, Eric;Mille, Stephane. And the article was included in European Journal of Organic Chemistry in 2000.Electric Literature of C8H7IO2 This article mentions the following:

The syntheses of biphenyls I and II substituted by two ω-cyanoalkyl chains (one on each ring) are described. Treatment of the unsym. I with NaN(Me)Ph in a Thorpe-Ziegler reaction failed to give any definite product. Under the same conditions, sym. II led to an isomeric mixture of dimeric enamino nitriles III [X = CH₂C(NH₂):C(CN), X¹ = CH₂C(NH₂):C(CN) or C(CN):C(NH₂)CH₂]. Mild acidic hydrolysis of the latter yielded the isomeric β-keto nitriles III [X = CH₂COCH(CN), X¹ = CH(CN)COCH₂], whereas more drastic hydrolytic conditions led to the macrocyclic diketone III (X, X¹ = CH₂COCH₂). In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Electric Literature of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A general synthesis of five, six and seven-membered silasultones via dehydrative cyclisation was written by Braddock, D. Christopher;Peyralans, Jerome J.-P.. And the article was included in Tetrahedron in 2005.COA of Formula: C4H8ClI This article mentions the following:

Five, six and seven-membered silasultones (I) can be conveniently prepared in good yield by dehydrative cyclization of siloxane disulfonic acids HO₃S(CH₂)_nCH₂SiR₂OSiR₂CH₂(CH₂)_nSO₃H (n = 1-3). The siloxanes are prepared by protodesilylation of the corresponding phenylsilane sulfonic acids. The sulfonate group is introduced either by free-radical sulfonation of vinyl silanes, or by S_N2 sulfite displacement of a long chain alkyl chloride. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9COA of Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Enantioselective Synthesis of 3-Fluorochromanes via Iodine(I)/Iodine(III) Catalysis was written by Sarie, Jerome C.;Thiehoff, Christian;Neufeld, Jessica;Daniliuc, Constantin G.;Gilmour, Ryan. And the article was included in Angewandte Chemie, International Edition in 2020.Quality Control of Methyl 3,5-dihydroxy-4-iodobenzoate This article mentions the following:

The chromane nucleus is common to a plenum of bioactive small mols. where it is frequently oxidized at position 3. Motivated by the importance of this position in conferring efficacy, and the prominence of bioisosterism in drug discovery, an iodine(I)/iodine(III) catalysis strategy to access enantioenriched 3-fluorochromanes is disclosed (up to 7:93 e.r.). In situ generation of ArIF₂ enables the direct fluorocyclization of allyl Ph ethers to generate novel scaffolds that manifest the stereoelectronic gauche effect. Mechanistic interrogation using deuterated probes confirms a stereospecific process consistent with a type II_inv pathway. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Quality Control of Methyl 3,5-dihydroxy-4-iodobenzoate).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Quality Control of Methyl 3,5-dihydroxy-4-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Spiroannulation by alkylation and reductive cyclization of nitriles was written by Rychnovsky, Scott D.;Takaoka, Leo R.. And the article was included in Angewandte Chemie, International Edition in 2003.Recommanded Product: 10297-05-9 This article mentions the following:

Spirocyclic rings were prepared from 2-cyanotetrahydropyrans. E.g., lithiation of 2-cyano-2-alkenyltetrahydropyran I (R = n-C₅H₁₁), prepared from 2-cyano-6-pentyltetrahydropyran, by lithium di-tert-butylbiphenylide led to the spirocyclic compound II. This two step sequence, alkylation and reductive cyclization, is used to generate five- and six-membered rings, and is highly stereoselective. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com