Category: iodides-buliding-blocks

Two-point halogen bonding between 3,6-dihalopyromellitic diimides was written by Cao, Dennis;Hong, Michael;Blackburn, Anthea K.;Liu, Zhichang;Holcroft, James M.;Stoddart, J. Fraser. And the article was included in Chemical Science in 2014.HPLC of Formula: 3268-21-1 This article mentions the following:

The syntheses of 3,6-dichloro-, -dibromo-, and -diiodopyromellitic diimides-ACl, ABr, and AI, resp.-have been achieved. X-Ray crystallog. of single crystals of ACl and ABr unveils the formation of extensive halogen-bonding networks in the solid state as a consequence of interactions between the lone pairs on the carbonyl oxygen atoms with the σ-holes of the halogen atoms. Further, the solid-state superstructure of diiodopyromellitic diimide is characterized by the formation of associated halogen-π dimers. The co-crystallization of ACl or ABr with a 1,5-diaminonaphthalene derivative DN yields co-crystals of a mixed-stack charge-transfer (CT) complex which are supported by an expansive hydrogen-bonded network in addition to halogen-bonded belts that bring adjacent mixed-stacks into association with each other. 2,6-Dimethoxynaphthalene (DO) proved to be an effective CT complement to AI, yielding solvent-free co-crystals with superstructures which are comprised of a 1 : 2 ratio of AI to DO. This dimeric halogen-bonding motif is reminiscent of the formation of hydrogen-bonded dimers between carboxylic acids. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1HPLC of Formula: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.HPLC of Formula: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Construction of Halogen-Bonded Organic Frameworks (XOFs) as Novel Efficient Iodinating Agents was written by Xia, Ning;Han, Jixin;Xie, Fei;Gong, Guanfei;Wang, Lu;Wang, Jike;Chen, Shigui. And the article was included in ACS Applied Materials & Interfaces in 2022.Name: 4-Iodo-1,2-dimethoxybenzene This article mentions the following:

The structural diversity and the various applications of organic frameworks have attracted much attention in recent years. Recently, halogen-bonded organic frameworks (XOFs) became a novel member of these materials, thereby facilitating the exploration of the interesting structures as well as functions. Here the authors present two types of [N···I⁺···N] connected XOFs (XOF-TPy and XOF-TPEB) with two tridentate ligands , 1,3,5-tri(pyridin-4-yl)benzene (TPy) and 1,3,5-tri-4-pyridyl-1,2-ethenylbenzene (TPEB), as building blocks. XOF-TPy and XOF-TPEB were characterized by ¹H NMR, UV-vis, XPS, IR, SEM, and HR-TEM. Two-dimensional (2D) structural models were established based on powder X-ray diffraction (PXRD) data and theor. simulations. Further experiment showed that these XOFs were excellent iodinating agents for the substituted arylboronic acids with either the electron-donating or electron-withdrawing groups upon heating without any catalyst. This research not only brings further understanding to the XOFs but also extends the applications of XOFs. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Name: 4-Iodo-1,2-dimethoxybenzene).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Name: 4-Iodo-1,2-dimethoxybenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic Asymmetric Homologation of α-Ketoesters with α-Diazoesters: Synthesis of Succinate Derivatives with Chiral Quaternary Centers was written by Li, Wei;Liu, Xiaohua;Tan, Fei;Hao, Xiaoyu;Zheng, Jianfeng;Lin, Lili;Feng, Xiaoming. And the article was included in Angewandte Chemie, International Edition in 2013.Product Details of 10297-05-9 This article mentions the following:

In the presence of Y(OTf)₃ and proline- or pipecolic acid-derived N,N’-dioxide ligand, the first catalytic asym. homologation of α-ketoesters R¹C(O)CO₂Me (R¹ = Me, Ph, 3-MeC₆H₄, 4-H₂C:CHC₆H₄, piperonyl, 2-naphthyl, etc.) with α-diazo esters R²C(N₂)CO₂Ad [Ad = 1-adamantyl; R² = Me, Et, n-decyl, H₂C:CHCH₂, HCCHCH₂, N₃(CH₂)₃, etc.] through either a 1,2-aryl or 1,2-alkyl shift was accomplished. Highly functionalized succinate derivatives MeO₂CC(O)CR¹R²CO₂Ad containing a quaternary stereocenter were obtained in excellent yields and with good enantioselectivities under mild conditions. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Product Details of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Product Details of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-Catalyzed protecting-group-free cross-couplings of iodophenols with atom-economic triarylbismuth reagents was written by Rao, Maddali L. N.;Meka, Suresh. And the article was included in Tetrahedron Letters in 2020.SDS of cas: 207115-22-8 This article mentions the following:

An efficient protocol for the protecting-group-free synthesis of unsym. hydroxybiaryls ArAr¹ [Ar = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar¹ = 2-HOC₆H₄, 4-HOC₆H₄, 2-HO-5-BrC₆H₃, etc.] via the Pd-catalyzed cross-couplings of unprotected iodophenols with triarylbismuth reagents was described. The presented protocols exhibited good to high yields of hydroxybiaryls. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8SDS of cas: 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Langmuir and Langmuir-Blodgett films of low-bandgap polymers was written by Braunger, Maria L.;Assuncao da Silva, Edilene;Awada, Hussein;de Oliveira, Vinicius J. R.;Silva, Hugo Santos;Begue, Didier;Hiorns, Roger C.;Lartigau-Dagron, Christine;Olivati, Clarissa de Almeida. And the article was included in Polymer International in 2018.Quality Control of Bis(2-iodothiophen-3-yl)methanone This article mentions the following:

Low-bandgap conjugated polymers have provided a considerable increase in organic photovoltaic efficiencies, however, an understanding of class-specific nanostructures, necessary to further improve device qualities, remains scarce. Their self-assembly and associated electronic behaviors in Langmuir-Blodgett (LB) films are used here to provide relationships specific to each polymer, clarifying their structure-property characteristics. The behavior of two low-bandgap polymers based on cyclopentadithiophene (PCPDTBT) and dithienosilole (Si-PCPDTBT) units in the Langmuir trough were investigated and it is shown that it is possible to fabricate nanostructured films of low-bandgap polymers on solid substrates with the LB deposition technique. The polymers were mixed with amphiphilic mols. at well-defined concentrations to improve the formation of the LB films. The polymers were also deposited by drop-casting and LB techniques onto interdigitated electrodes to evaluate their elec. properties, and the LB films were characterized for their optical and morphol. properties. It was found that both LB and drop-cast films of PCPDTBT showed higher elec. conductivities than those of Si-PCPDTBT. Importantly, LB films resulted in higher elec. conductivities – by an order of magnitude – compared to their equivalent mixtures with stearic acid in drop-cast films, although drop-cast films without stearic acid gave higher conductivities. This fine-tuning of the mol. architectures of the films is thus demonstrated to directly affect the phys. properties and may lead to an improvement in device efficiencies in future applications. © 2018 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0Quality Control of Bis(2-iodothiophen-3-yl)methanone).

Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Quality Control of Bis(2-iodothiophen-3-yl)methanone

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Direct Synthesis of Methylene-Bridged Bis-biaryl Carboxylates via Cascade Suzuki Coupling and CH₂Cl₂-Based Bis-esterification was written by Xiong, Jin;Zhong, Guofeng;Zou, Lianghua;Liu, Yunyun. And the article was included in ChemistrySelect in 2018.Application of 13420-63-8 This article mentions the following:

The synthesis of bis-biaryl carboxylates such as I [R¹ = H, 4-Me, 3-Cl, 3-F; R² = H, 4-CH₃, 4-Cl, etc.] were designed via Pd-catalyzed multicomponent cascade Suzuki coupling and bis-esterification of iodobenzoic acids, arylboronic acids with dichloromethane. The present work offered a direct and practical route to the synthesis of novel carboxylate scaffolds with extended diversity. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Application of 13420-63-8).

2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application of 13420-63-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A facile synthesis of various fluorine-containing indole derivatives via palladium-catalyzed annulation of internal alkynes was written by Chae, Jungha;Konno, Tsutomu;Ishihara, Takashi;Yamanaka, Hiroki. And the article was included in Chemistry Letters in 2004.Safety of 4,5-Dichloro-2-iodoaniline This article mentions the following:

The palladium-catalyzed annulation reaction of a variety of fluorine-containing internal alkynes with 2-iodoaniline derivatives took place smoothly to give the corresponding 2,3-disubstituted indoles, e.g., I, in good to excellent yields. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Safety of 4,5-Dichloro-2-iodoaniline).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 4,5-Dichloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Halogen bonding in drug-like molecules: a computational and systematic study of the substituent effect was written by Adasme-Carreno, Francisco;Munoz-Gutierrez, Camila;Alzate-Morales, Jans H.. And the article was included in RSC Advances in 2016.Recommanded Product: 1,2-Difluoro-3-iodobenzene This article mentions the following:

Halogen bonding (XB) is a noncovalent interaction that has been increasingly used in mol. recognition, and more recently, in protein-ligand binding. We have studied and quantified, using d. functional theory (DFT) calculations, the substituent effect of fourteen chem. groups in the chloro-, bromo- and iodobenzene···N-methylacetamide (NMA) complexes, which serve as a model of a common arrangement of XB in biol. systems. A total of 126 halobenzene···NMA complexes have been optimized and examined regarding their relative energy, mol. electrostatic potential, topol. anal. of electron d. and charge transfer. The extent of substituent effect was found to be up to 1.5 kcal mol^-1, where electron-withdrawing groups increase the XB strength while electron-donating substituents reduce it. Excellent statistical correlations (R² > 0.9) were obtained for the comparison between XB interaction energy and the computed electronic properties (electron d., mol. electrostatic potential, and NBO charges), suggesting that the substituent effect was mainly due to the electrostatic interaction, and resonance effects were negligible. Furthermore, a pos. cooperativity effect, in the strengthening of the XB, was observed in NMA complexes with di-, tri- and tetrafluoro-iodobenzenes. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Recommanded Product: 1,2-Difluoro-3-iodobenzene).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 1,2-Difluoro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery, synthesis, and biological evaluation of a novel group of selective inhibitors of filoviral entry was written by Yermolina, Maria V.;Wang, Ji-Zhen;Caffrey, Michael;Rong, Li-Jun L.;Wardrop, Duncan J.. And the article was included in Journal of Medicinal Chemistry in 2011.Electric Literature of C8H7IO2 This article mentions the following:

Herein, we report the development of an antifiloviral screening system, based on a pseudotyping strategy, and its application in the discovery of a novel group of small mols. that selectively inhibit the Ebola and Marburg glycoprotein (GP)-mediated infection of human cells. Using Ebola Zaire GP-pseudotyped HIV particles bearing a luciferase reporter gene and 293T cells, a library of 237 small mols. was screened for inhibition of GP-mediated viral entry. From this assay, lead compound I was identified as a selective inhibitor of filoviral entry with an IC₅₀ of 30 μM. To analyze functional group requirements for efficacy, a structure-activity relationship anal. of this 3,5-disubstituted isoxazole was then conducted with 56 isoxazole and triazole derivatives prepared using “click” chem. This study revealed that while the isoxazole ring can be replaced by a triazole system, the 5-(diethylamino)acetamido substituent found in I is required for inhibition of viral-cell entry. Variation of the 3-aryl substituent provided a number of more potent antiviral agents with IC₅₀ values ranging to 2.5 μM. Lead compound I and three of its derivatives were also found to block the Marburg glycoprotein (GP)-mediated infection of human cells. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Electric Literature of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Electric Literature of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stereospecific Ni-Catalyzed Cross-Coupling of Potassium Alkenyltrifluoroborates with Alkyl Halides was written by Molander, Gary A.;Argintaru, O. Andreea. And the article was included in Organic Letters in 2014.Computed Properties of C4H8ClI This article mentions the following:

A general method for the alkenylation of alkyl electrophiles using nearly stoichiometric amounts of the air- and moisture-stable potassium organotrifluoroborates has been developed. Various functional groups were tolerated on both the nucleophilic and electrophilic partner. Reactions of highly substituted E- and Z-alkenyltrifluoroborates, as well as vinyl- and propenyltrifluoroborates, were successful, and no loss of stereochem. or regiochem. was observed In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com