Electric Literature of 957193-64-5, The chemical industry reduces the impact on the environment during synthesis 957193-64-5, name is 7-Iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one, I believe this compound will play a more active role in future production and life.
C) 7-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one Under nitrogen atmosphere, to a solution of 7-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one (12.5 g) in a mixed solvent of N,N-dimethylformamide (200 mL) and dimethyl sulfoxide (600 mL) was slowly added 1 M potassium 1,1,1,3,3,3-hexamethyldisilazane/tetrahydrofuran solution (63.6 mL) under ice-cooling. The reaction mixture was stirred at 0C for 30 min, and [2-(chloromethoxy)ethyl](trimethyl)silane (11.3 mL) was slowly added thereto at the same temperature. The reaction mixture was stirred at room temperature for 2 hr, and the solvent was evaporated under reduced pressure. To the residue was added aqueous sodium carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane/ethyl acetate) to give the title compound (6.86 g). 1H NMR (400 MHz, DMSO-d6) delta 0.01 (9H, s), 0.90 (2H, t, J = 7.6 Hz), 3.59 (2H, t, J = 8.0 Hz), 4.07 (2H, d, J = 1.6 Hz), 5.31 (2H, s), 7.55 (1H, d, J = 1.6 Hz), 7.92 (1H, d, J = 2.0 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Pharmaceutical Company Limited; MIKAMI, Satoshi; NAKAMURA, Shinji; ASHIZAWA, Tomoko; SASAKI, Shigekazu; TANIGUCHI, Takahiko; NOMURA, Izumi; KAWASAKI, Masanori; EP2848618; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com