Category: 939759-26-9

Parmar, Dixit published the artcileIron catalysed cross-couplings of azetidines – application to the formal synthesis of a pharmacologically active molecule, Formula: C11H12INO2, the main research area is iron catalyzed coupling azetidine Grignard reagent; azetidine pharmacol active agent preparation CNS disorder.

A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacol. active mol. was shown.

Chemical Communications (Cambridge, United Kingdom) published new progress about Central nervous system disease. 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Formula: C11H12INO2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yi, Jun published the artcileNickel-catalyzed Sonogashira reactions of non-activated secondary alkyl bromides and iodides, HPLC of Formula: 939759-26-9, the main research area is internal alkyne preparation; terminal alkyne alkyl halide Sonogashira coupling nickel catalyst; alkynes; cross-coupling; halides; nickel; synthetic methods.

A nickel-catalyzed Sonogashira cross-coupling of terminal alkynes with non-activated secondary alkyl iodides and bromides is described. This reaction provides a useful approach to the synthesis of substituted alkynes (in particular, dialkylated asym. alkynes) from readily available substrates. The bis(oxazoline) family of ligands was found to be effective for mediating nickel-catalyzed C(sp)-C(sp3) cross-couplings of both secondary and primary alkyl halides under fairly mild reaction conditions (room temperature to -20°C). This reaction exhibited good compatibility with a variety of synthetically important functional groups and therefore, could be used for the synthesis and modifications of biol. relevant mols. Furthermore, high diastereoselectivities were observed in C(sp)-C(sp3) cross-couplings of terminal alkynes with 1,3- and 1,4-substituted cyclohexyl iodides.

Angewandte Chemie, International Edition published new progress about Alkynes, α- Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, HPLC of Formula: 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xi published the artcileNickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides, Name: Benzyl 3-iodoazetidine-1-carboxylate, the main research area is arylfluoroalkene chemoselective diastereoselective preparation; nickel imidazolinylpyridine catalyst defluorinative reductive coupling aryldifluoroalkene bromoalkane iodoalkane; secondary tertiary bromoalkane chloroalkane reductive coupling aryldifluoroalkene nickel catalyst.

In the presence of Ni(cod)2 and an imidazolinylpyridine ligand, 1,1-difluoroalkenes such as I underwent chemoselective and diastereoselective reductive defluorinative coupling reactions with secondary alkyl bromides and iodides such as iodocyclohexane mediated by bis(pinacolato)diboron and tripotassium phosphate to yield (Z)-arylfluoroalkenes such as II in 36-95% yields and in 8:1->50:1 Z:E diastereoselectivities; the reaction was also used to couple difluoroalkenes with primary alkyl iodides and 1,1-difluoroalkyl bromides using a catalyst generated from NiBr2(diglyme) and 4,7-dimethoxy-1,10-phenanthroline.

Journal of the American Chemical Society published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Name: Benzyl 3-iodoazetidine-1-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yi, Jun published the artcileNickel-catalyzed Sonogashira reactions of non-activated secondary alkyl bromides and iodides, HPLC of Formula: 939759-26-9, the main research area is internal alkyne preparation; terminal alkyne alkyl halide Sonogashira coupling nickel catalyst; alkynes; cross-coupling; halides; nickel; synthetic methods.

A nickel-catalyzed Sonogashira cross-coupling of terminal alkynes with non-activated secondary alkyl iodides and bromides is described. This reaction provides a useful approach to the synthesis of substituted alkynes (in particular, dialkylated asym. alkynes) from readily available substrates. The bis(oxazoline) family of ligands was found to be effective for mediating nickel-catalyzed C(sp)-C(sp3) cross-couplings of both secondary and primary alkyl halides under fairly mild reaction conditions (room temperature to -20°C). This reaction exhibited good compatibility with a variety of synthetically important functional groups and therefore, could be used for the synthesis and modifications of biol. relevant mols. Furthermore, high diastereoselectivities were observed in C(sp)-C(sp3) cross-couplings of terminal alkynes with 1,3- and 1,4-substituted cyclohexyl iodides.

Angewandte Chemie, International Edition published new progress about Alkynes, α- Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, HPLC of Formula: 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com