Application of 930599-57-8,Some common heterocyclic compound, 930599-57-8, name is 4-Iodo-2-methyl-1-(trifluoromethyl)benzene, molecular formula is C8H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To intermediate 164d (3.5 g, 12.24 mmol, 1.00 equiv) in CC14 (40 mL) at 60 C was added benzoyl peroxide (1.7 g, 7.02 mmol, 0.57 equiv) followed by the batch-wise addition of NBS (2.37 g, 13.32 mmol, 1.09 equiv) and the reaction stirred at reflux overnight. The solids were filtered out and the filtrate concentrated to afford 1.6 g (36%) of intermediate 164e as a red oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-2-methyl-1-(trifluoromethyl)benzene, its application will become more common.
Reference:
Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com