Electric Literature of 914106-26-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 914106-26-6, name is 4-Chloro-3-iodobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 4-chloro-3-iodobenzonitrile (0.80 g, 3.0 mmol) in THF (16 mL) under nitrogen was added BH3-THF (1M in THF, 4.8 mL, 4.8 mmol). After stirring for 30 minutes at room temperature, the reaction mixture was heated to reflux for 8 hours. The reaction mixture was cooled to 0C, and a 2M aqueous HCI solution (4.5 mL) was added slowly. The reaction mixture was allowed to warm to room temperature, and heated to reflux for 2.5 hours. After cooling to room temperature, the mixture was concentrated in vacuo to yield crude Intermediate 6A which was used without purification. 1H NMR (CD3OD) delta 8.07 (d, 1H), 7.58 (d, 1H), 7.48 (m, 1H), 4.10 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 4-Chloro-3-iodobenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; VENENUM BIODESIGN LLC; HUANG, Chia-Yu; SHI, Dongchuan; KULTGEN, Steven G.; MCGUINNESS, Brian F; LETOURNEAU, Jeffrey J.; COLE, Andrew G.; BEASLEY, James R.; (358 pag.)WO2018/5801; (2018); A2;,
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