Adding a certain compound to certain chemical reactions, such as: 89976-43-2, name is 4-Iodo-N-methylbenzamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89976-43-2, Computed Properties of C8H8INO
2e) N-Methyl-4-trimethylsilanylethynyl-benzamide A mixture of 4-iodo-N-methylbenzenamide (26.1 g, 0.1 mole), 2.5 g of PdCl2(PPh3)2 (3,5%) and 1.6 g Cul (8%) in 200 ml of toluene was stirred for 30 min under argon. Than 1-ethynyl(trimethyl)silane (10 g, 0.102 mole) and Et3N (40.4 g, 0.4 mole) was added. This mixture was stirred for 2-3 hours under argon at r.t. Sub products were filtered off. The solvent was evaporated product was purified by flash chromatography with CHCl3. Chloroform was evaporated and product was crystallized from hexane. Yield – 17.65 g (75.7%)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-N-methylbenzamide, and friends who are interested can also refer to it.
Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; EP2020404; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com