Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 886762-68-1, name is 1,3-Difluoro-5-iodo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., name: 1,3-Difluoro-5-iodo-2-methoxybenzene
Example 12i 5-(3-Bromo-4-fluorophenyl)-5-(3,5-difluoro-4-methoxyphenyl)-5H-pyrrolo[3,4-b]pyridin-7-amine tert-Butyllithium (0.995 mL, 1.59 mmol) was added dropwise to THF (4 mL) at -100 C. under an argon atmosphere. A solution of 1,3-difluoro-5-iodo-2-methoxybenzene (215 mg, 0.80 mmol) in THF (1 mL) was added dropwise followed by the addition of N-((3-bromo-4-fluorophenyl)(2-cyanopyridin-3-yl)methylene)-2-methylpropane-2-sulfinamide (250 mg, 0.61 mmol) in THF (2 mL). The resulting reaction mixture was left on the thawing cooling bath for 30 min then the cooling bath was removed and the mixture was stirred at r.t. for 1 h. Hydrogen chloride in methanol (3 mL, 3.7 mmol) was added and the resulting mixture was stirred at r.t. for 1 h. The mixture was concentrated and purified on a silica gel column eluted with 0-10% NH3 (0.1 M in MeOH) in DCM. This gave 52 mg (19% yield) of the title product: MS (ES) m/z 448, 450 [M+1]+.
According to the analysis of related databases, 886762-68-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; US2010/125081; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com