Sun, Zhenhua published the artcileSyntheses of Pyridine C-Nucleosides as Analogues of the Natural Nucleosides dC and dU, Safety of 6-Fluoro-5-iodopyridin-2-ol, the main research area is hydrogen bond pyridine nucleoside synthesis palladium catalyst coupling; pyridine C nucleoside synthesis Heck palladium catalyst coupling.
The syntheses of four pyrimidine C-nucleosides are described. These derivatives are designed as mimics of dC and dU, and in that respect, each can form two hydrogen bonds with complementary dG or dA residues. The minor groove O2 carbonyl in each derivative is replaced by a fluorine or a Me group. The key carbon-carbon bond connecting the heterocycle to the carbohydrate is formed using a Heck-type palladium-mediated coupling reaction.
Journal of Organic Chemistry published new progress about Coupling reaction. 884660-48-4 belongs to class iodides-buliding-blocks, name is 6-Fluoro-5-iodopyridin-2-ol, and the molecular formula is C5H3FINO, Safety of 6-Fluoro-5-iodopyridin-2-ol.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com