Related Products of 883546-30-3, A common heterocyclic compound, 883546-30-3, name is 2-Bromo-4-(trifluoromethoxy)iodobenzene, molecular formula is C7H3BrF3IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A suspension of the boronic acid (360 mg, 1.6 mmol), 2-bromo-1-iodo-4-(trifluoromethoxy)benzene (575 mg, 1.6 mmol), dppf(Pd)Cl2 (57 mg, 0.078 mmol), potassium carbonate (433 mg, 3.1 mmol) in degassed toluene (4 mL), degassed water (2 mL) and degassed ethanol (2 mL) was heated at 45 C. for 3 hours. The layers were separated and the organics were concentrated and purified by column chromatography to provide the desired product.426.0 (M+1).1H NMR (CDCl3) d 8.23 (s, 1H), 7.99 (s, 1H), 7.64 (s, 1H), 7.30-7.53 (m, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Gilead Palo Alto, Inc.; US2011/21521; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com