Category: 88-67-5

Reference of 88-67-5,Some common heterocyclic compound, 88-67-5, name is 2-Iodobenzoic acid, molecular formula is C7H5IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of carboxylic acid (1.0 eq.) in ethanol (2 M) was added thionyl chloride (2.0 eq.) dropwise at room temperature, and then refluxed for 2 hours. After it was cooled to room temperature, the reaction mixture was concentrated under reduced pressure to give crude product, which was chromatographed on silica gel column using 1:30 (v/v) EtOAc-petroleum ether solution as eluent to afford isolated product esters in 80% – 95% yields. Esters (1.0 eq.) were added dropwise to a stirred solution of acetonitrile (2.0 eq.) and NaH (3.0 eq.) in THF (2 M) at room temperature, and then refluxed for 1h . After it was cooled to room temperature, Water was added dropwise to the reaction mixture under ice bath until no gas bubbles generated, and employing dilute hydrochloric acid neutralization to neutral, extracted with ethyl acetate, dried over magnesium sulfate and concentrated in vacuo to give crude product which was chromatographed on silica gel column using 1:4 to 1:2 (v/v) EtOAc-petroleum ether solution as eluent to afford isolated product beta-ketonitriles, white or light yellow solid compounds in 50% – 85% yields. Finally, stirred in concentrated sulfuric acid (3 M) at room temperature for 5 to 10 hours. The reaction mixture was neutralized to neutral by ammonia water, extracted with ethyl acetate, dried over magnesium sulfate and concentrated in vacuo to give crude product which was chromatographed on silica gel column using 1:1 to 2:1 (v/v) EtOAc-petroleum ether solution as eluent to afford isolated product beta-ketoamides 1a-p, white solid compounds in 45% – 85% yields.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodobenzoic acid, its application will become more common.

Reference:
Article; Zheng, Congke; Zhang, Xiaohui; Ijaz Hussain, Muhammad; Huang, Mingming; Liu, Qing; Xiong, Yan; Zhu, Xiangming; Tetrahedron Letters; vol. 58; 6; (2017); p. 574 – 577;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

88-67-5, name is 2-Iodobenzoic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Iodobenzoic acid

General procedure: In a four-necked flask equipped with a thermometer and a stirrer, after dissolving 13.9 g of o-fluorobenzoic acid in 69.5 g of sulfuric acid and 55.6 g of DCM, 4.5 g of sodium iodate and 13.0 g of iodine were added to the reaction solution, and stirring was started to control the reaction. The temperature is 25-30 C, the reaction is kept for 1 h, and a purple solid is precipitated in the reaction liquid. After the reaction of the raw material is completed, the reaction solution is poured into a cold aqueous solution of sodium thiosulfate to be quenched, the reaction solution is spun and filtered, and 41.7 ml is used. Recrystallization of methanol gave 20 g of 2-fluoro-5-iodobenzoic acid. The yield was 75.8% and the purity was 99.0%.

The synthetic route of 88-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hangzhou Keyao Pharmaceutical Technology Co., Ltd.; Ren Chuan; Zhou Junming; (7 pag.)CN110078613; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 88-67-5, name is 2-Iodobenzoic acid, A new synthetic method of this compound is introduced below., SDS of cas: 88-67-5

Synthesized according to a slight modification of two previously reported procedures.18 Neat2-iodobenzoic acid (3.00 g, 12.1 mmol) was cooled down to 0 C, to which was added a mixture offuming HNO3 (3.0 mL) and concentrated H2SO4 (13.5 mL). This mixture was then stirred at 0 C for 1 h,then at rt for 30 min, and finally at 135 C for 2 h, before being cooled back down to rt. The resultingsolution was poured into plenty of ice water and filtered. The solid was transferred to an Erlenmeyer flaskand suspended in water (300 mL), then heated to a boil. A solution of KI (2.41 g, 14.5 mmol) in water (15mL) acidified to pH 3 with a few drops of concentrated H2SO4 was added portion-wise to this boiling suspension (I2 vapors were generated with each portion). Omitting this step as in Subramanian?s reportyields the iodoso analog. The solution was filtered while still boiling, then the filtrate was stored at 4 Cfor 18 h after which time the desired compound precipitated. 2-Iodo-5-nitrobenzoic acid was thencollected by filtration while still cold to afford 1.73 g (49%) as a 13:2 mixture with the undesired2-iodo-3-nitrobenzoic acid isomer. The inseparable mixture was used as is in the next step.Characterization matches the data previously reported in the literature

The synthetic route of 88-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aubert-Nicol, Samuel; Heinrich, Nora; Lessard, Jean; Spino, Claude; Heterocycles; vol. 99; 1; (2019); p. 484 – 501;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 88-67-5, name is 2-Iodobenzoic acid, A new synthetic method of this compound is introduced below., Computed Properties of C7H5IO2

General procedure: Hydrazides (30-58) were synthesized by one pot conventionalmethod24 Benzoic acid or its derivative (10 mmol) was dissolvedin ethanol (20 mL). Sulfuric acid (3 N, 2 mL) was added and thereaction contents were refluxed for six hours. The reaction wasmonitored with TLC. After the completion of the reaction, the reactionmixture was neutralized by adding solid NaHCO3, and filteredto remove excess of NaHCO3. In the neutralized reaction mixture which contains ethyl ester, hydrazine monohydrate (1.5 mL,3 mmol) was added and refluxed for 3-6 h to complete the reaction.Ethanol and unreacted hydrazine were removed by distillationupto 1/3 volume. The reaction contents were cooled, filteredand recrystallized from methanol to obtain the desired hydrazidecrystals (see Supporting information).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, SDS of cas: 88-67-588-67-5, Name is 2-Iodobenzoic acid, SMILES is O=C(O)C1=CC=CC=C1I, belongs to iodides-buliding-blocks compound. In a article, author is Drozd, Anatoliy V., introduce new discover of the category.

Spectrophotometric determination of trace amounts of iodide-ions in form of ionic associate with brilliant green using electrochemical oxidation

A combined method involving electrochemical oxidation of iodide to iodate at a platinum electrode followed by extraction in CCl4 of ionic associates of iodine-iodide complexes with brilliant green, formed in excess of iodide, was developed for the spectrophotometric quantification of iodide. The slope of the calibration curve yields a molar extinction coefficient of epsilon = 3.10(5) L mol(-1)cm(-1). This method can be used for the quantification of iodide in the concentration range of 3.10(-7) – 3.10(-6) mol L-1 with a detection limit of 5.10(-8) mol L-1. The interfering effect of other ions on the determination of the iodide concentration was also investigated. The method was successfully applied for the determination of iodide in real samples of NaCl and spring water. Relative standard deviation is 1 – 2%.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 88-67-5. SDS of cas: 88-67-5.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 2-Iodobenzoic acid, 88-67-5, Name is 2-Iodobenzoic acid, SMILES is O=C(O)C1=CC=CC=C1I, in an article , author is Liu, Xue-Wei, once mentioned of 88-67-5.

Trace determination of mutagenic alkyl toluenesulfonate impurities via derivatization headspace-GC/MS in an active pharmaceutical ingredient of a candidate drug

This study aims to optimize sodium iodide (Nal) derivatization headspace-GC/MS described in European Pharmacopoeia by using vitamin C as an alternative antioxidant for the determination of mutagenic alkyl toluenesulfonate impurities in an active pharmaceutical ingredient (API) of a candidate drug with an artemisinin derivative. Alkyl toluenesulfonates are transformed into their corresponding alkyl iodides (methyl iodide, ethyl iodide, propyl iodide, and isopropyl iodide) by utilizing the derivatization reagent Nal. Results show that the MS response of methyl iodide is a critical indicator of method robustness because of the deteriorating effects of methyl iodide on stability when sodium thiosulfate is used as an antioxidant originally described in the pharmacopoeia. With vitamin C as a newly developed antioxidant, the robustness of this method is improved significantly. The optimized method is further validated and applied successfully for the quality control and safety of the API of an artemisinin derivative. (C) 2018 Elsevier B.V. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 88-67-5, you can contact me at any time and look forward to more communication. Recommanded Product: 2-Iodobenzoic acid.

Chemistry is an experimental science, SDS of cas: 88-67-5, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 88-67-5, Name is 2-Iodobenzoic acid, molecular formula is C7H5IO2, belongs to iodides-buliding-blocks compound. In a document, author is Zhao, Yinlong.

A review on the mechanism of iodide metabolic dysfunction in differentiated thyroid cancer

The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly worldwide, and the risk factors remain unclear. With the growing number of patients with DTC, the related issues have been gradually highlighted. (131)Iodide (I-131) is an important treatment for DTC and has the potential to reduce the risk of recurrence. 131I is also an effective treatment for distant metastases of thyroid carcinoma. However, iodide metabolism dysfunction in metastatic foci causes patients to lose the opportunity of I-131 treatment. This article reviews the related mechanisms of iodide metabolism dysfunction in DTC cells and summarizes the clinical transformation progression.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 88-67-5, in my other articles. SDS of cas: 88-67-5.

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 88-67-5, Name is 2-Iodobenzoic acid, molecular formula is , belongs to iodides-buliding-blocks compound. In a document, author is Lin, FM, Category: iodides-buliding-blocks.

Highly sensitive analysis of iodide anion in seaweed as pentafluorophenoxyethyl derivative by capillary gas chromatography

A simple and sensitive gas chromatography (GC) method is described for the trace analysis of iodide anion (iodide) in processed seaweed as an organic derivative. The method is based on the derivatization of aqueous iodide extracted from seaweed with 2-(pentafluorophenoxy)ethyl 2-(piperidino)ethanesulfonate in toluene using tetra-n-hexylammonium bromide as a phase-transfer catalyst. The resulting pentafluorophenoxyethyl iodide is highly responsive to an electron-capture detector (ECD) and was analyzed by GC-ECD, giving a low detection limit of similar to2.7 nM (2.7 fmol/muL injected). Interferences of some common anions in the analysis of iodide were studied and proved to be minimal. Application of the method to the analysis of iodide in processed seaweed was performed.

If you are hungry for even more, make sure to check my other article about 88-67-5, Category: iodides-buliding-blocks.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 88-67-5, Name is 2-Iodobenzoic acid, SMILES is O=C(O)C1=CC=CC=C1I, belongs to iodides-buliding-blocks compound. In a document, author is JOSEPH, R, introduce the new discover, Formula: C7H5IO2.

DIRECT CONVERSION OF ALCOHOLS INTO THE CORRESPONDING IODIDES

A mild and effective procedure for directly converting secondary, tertiary and benzylic alcohols into the corresponding iodides is described using I-2 in refluxing petroleum ether. The reaction proceeds with inversion of configuration.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 88-67-5 is helpful to your research. Formula: C7H5IO2.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 88-67-5, Name is 2-Iodobenzoic acid, molecular formula is C7H5IO2. In an article, author is Matsuyoshi, Hiroaki,once mentioned of 88-67-5, Safety of 2-Iodobenzoic acid.

Effects of 1,3-Alkylimidazolium Iodide on Electrolytes for Dye-Sensitized Solar Cell

The effects of 1,3-alkylimidazolium iodide derivatives in the electrolytic solution of dye-sensitized solar cell were investigated. The combination of lithium iodide and 1-ethyl-3-methylimdazolium iodide was revealed to exhibit higher efficiency (8.6%) than 1-methyl-3-propylimidazolium iodide or 1-butyl-3-methylimidazolium iodide. The influence of guanidine thiocyanate was examined for the electrolyte of 1-ethyl-3-methylimidazolium iodide.

Interested yet? Keep reading other articles of 88-67-5, you can contact me at any time and look forward to more communication. Safety of 2-Iodobenzoic acid.