Category: 88-67-5

In 2019,European Journal of Medicinal Chemistry included an article by Salah Ayoup, Mohammed; Wahby, Yasmin; Abdel-Hamid, Hamida; Ramadan, El Sayed; Teleb, Mohamed; Abu-Serie, Marwa M.; Noby, Ahmed. HPLC of Formula: 88-67-5. The article was titled 《Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators》. The information in the text is summarized as follows:

In the current study, a new series of multifunctional Passerini products was synthesized and evaluated as potent caspase-dependent apoptotic inducers. The synthetic strategy adopted this isocyanide-based multicomponent reaction to possibly mimic the pharmacophoric features of various lead apoptotic inducers, where a series of α-acyloxy carboxamides I (R = C2H5, CH2C6H5, 4-ClC6H4, etc.) was prepared from p-nitrophenyl isonitrile, cyclohexanone and various carboxylic acids RCOOH. Accordingly, the main amide-based scaffold was decorated by substituents with varying nature and size to gain more information about structure-activity relationship. All the synthesized compounds were screened for cytotoxicity against normal human fibroblasts and their potential anticancer activities against three human cancer cell lines; MCF-7 (breast), NFS-60 (myeloid leukemia), and HepG-2 (liver) utilizing MTT assay. Among the most active compounds, I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) were more potent and safer than doxorubicin with nanomolar IC50 values and promising selectivity indexes. Mechanistically, I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) induced apoptosis by significant caspase activation in all the screened cancer cell lines utilizing flow cytometric anal. and caspase 3/7 activation assay. Again, I (R = 4-NO2C6H4, CH(OH)C6H5) recorded higher activation percentages than doxorubicin, while I (R = CH2C6H5) showed comparable results. Apoptosis-inducing factor1 (AIF1) quantification assay declared that I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) didn’t mediate apoptosis through AIF1-dependent pathway (i.e. only by caspase activation). Physicochem. properties, pharmacokinetic profiles, ligand efficiency metrics and drug-likeness data of all the synthesized compounds were computationally predicted and showed that I (R = 4-NO2C6H4, CH(OH)C6H5, CH2C6H5) could be considered as drug-like candidates. Finally, selected compounds were preliminarily screened for possible antimicrobial activities searching for dual anticancer/antimicrobial agents as an advantageous approach for cancer therapy. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5HPLC of Formula: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 2-Iodobenzoic acidIn 2019 ,《Formation of Benzylic Iodides via a Nickel Catalyzed Diastereoselective Dearomative Carboiodination Reaction of Indoles》 was published in Angewandte Chemie, International Edition. The article was written by Marchese, Austin D.; Lind, Florian; Mahon, Aine E.; Yoon, Hyung; Lautens, Mark. The article contains the following contents:

A diastereoselective dearomative carboiodination reaction is reported. Herein, a novel metal-catalyzed approach for the preparation of reactive secondary benzylic iodides I (R1 = H, 8-Br, 9-Me, etc.; R2 = Me, Et, Ph, etc.; R3 = H, 2-OMe, 2-F) is reported. Utilizing the unique reactivity of nickel, the carboiodination reaction of non-activated aromatic double bonds provided a previously unattainable class of iodides. A broadly applicable method to avoid the use of a metallic reducing agent by utilizing an alkyl phosphite as the ligand has been discussed. The reaction is thought to proceed through a syn intramol. carbonickelation across 2-substituted indole, followed by a diastereoretentive reductive elimination of the carbon-iodine bond. The complex iodinated indolines generated in the reaction were obtained in moderate to good yields and good to excellent diastereoselectivity. The products were easily functionalized by a variety of synthetic methods. In the experiment, the researchers used many compounds, for example, 2-Iodobenzoic acid(cas: 88-67-5Safety of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Safety of 2-Iodobenzoic acid Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Carboxylate-Assisted Oxidative Addition to Aminoalkyl PdII Complexes: C(sp3)-H Arylation of Alkylamines by Distinct PdII/PdIV Pathway》 were Whitehurst, William G.; Blackwell, J. Henry; Hermann, Gary N.; Gaunt, Matthew J.. And the article was published in Angewandte Chemie, International Edition in 2019. Name: 2-Iodobenzoic acid The author mentioned the following in the article:

Reported is the discovery of an approach to functionalize secondary alkylamines using 2-halobenzoic acids as aryl-transfer reagents. These reagents promote an unusually mild carboxylate-assisted oxidative addition to alkylamine-derived palladacycles. In the presence of AgI salts, a decarboxylative C(sp3)-C(sp2) bond reductive elimination leads to γ-aryl secondary alkylamines and renders the carboxylate motif a traceless directing group. Stoichiometric mechanistic studies were effectively translated to a Pd-catalyzed γ-C(sp3)-H arylation process for secondary alkylamines. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Name: 2-Iodobenzoic acid Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liang, Ren-Xiao; Xu, Deng-Yun; Yang, Fu-Ming; Jia, Yi-Xia. Name: 2-Iodobenzoic acid. The article was titled 《A Pd-catalyzed domino Larock annulation/dearomative Heck reaction》. The information in the text is summarized as follows:

A palladium-catalyzed domino Larock annulation/dearomative Heck reaction was developed, which delivered a range of tetracyclic indoline derivatives in moderate to excellent yields through a Larock annulation of N-bromobenzoyl o-iodoanilines with alkynes and a subsequent intramol. dearomative Heck reaction. This protocol provided a straightforward route to structurally diverse indolines from readily available starting materials by forming two new rings and three chem. bonds in a single step. In the experiment, the researchers used many compounds, for example, 2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Name: 2-Iodobenzoic acid Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Transition metal-free and regioselective vinylation of phosphine oxides and H-phosphinates with VBX reagents》 was written by Castoldi, Laura; Rajkiewicz, Adam A.; Olofsson, Berit. Formula: C7H5IO2This research focused onvinylation regioselective phosphine oxide phosphinate vinylbenziodoxolone reagent; alkenyl phosphine oxide phosphinate preparation chemoselective regioselective. The article conveys some information:

A series of phosphine oxides and H-phosphinates were vinylated in the presence of the iodine(III) reagents vinylbenziodoxolones (VBX), providing the corresponding alk-1-enyl phosphine oxides and alk-1-enyl phosphinates in good yields with complete chemo- and regioselectivity. The vinylation proceeds in open flask under mild and transition metal-free conditions. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Name: 2-Iodobenzoic acidIn 2021 ,《Synthesis and evaluation of α-glucosidase inhibitory activity of sulfonylurea derivatives》 was published in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences. The article was written by Bui, Thi Thoi; Tran, Van Loc; Ngo, Dai Quang; Tran, Van Chien; Tran, Van Sung; Tran, Thi Phuong Thao. The article contains the following contents:

Two series of sulfonylureas derivatives include 24 compounds I (R = NH2, phenylamidyl, (3-methylpyridin-2-yl)amidyl, (quinoxalin-2-yl)amidyl, etc.) and II (R1 = OEt, cyclopentylaminyl, benzylaminyl, (2,3,4-trifluorophenyl)aminyl, etc.), among them, 17 new derivatives, have been synthesized and evaluated for their α-glucosidase inhibitory activity. Compounds I (R = (2E)-3-(4-hydroxyphenyl)prop-2-enamidyl; R = (2-hydroxy-3,5-diiodophenyl)amidyl) and II (R1 = [4-nitro-3-(trifluoromethyl)phenyl]aminyl) showed significant in vitro α-glucosidase inhibition with IC50 values of 5.58, 79.85 and 213.36μm, resp., comparing with the standard compounds acarbose (IC50 = 268.29μm) and glipizide (IC50 = 300.47μm). The preliminary structure-activity relationships (SARs) of the synthesized compounds I and II were also investigated.2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 88-67-5In 2019 ,《Iodine biofortification through expression of HMT, SAMT and S3H genes in Solanum lycopersicum L.》 was published in Plant Physiology and Biochemistry (Issy-les-Moulineaux, France). The article was written by Halka, Mariya; Smolen, Sylwester; Czernicka, Malgorzata; Klimek-Chodacka, Magdalena; Pitala, Joanna; Tutaj, Krzysztof. The article contains the following contents:

The uptake process and physiol. reaction of plants to aromatic iodine compounds have not yet been documented. The aim of this research was to compare uptake by tomato plants of KI and KIO3, as well as of organic iodine compounds – 5-ISA (5-iodosalicylic acid), 3,5-diISA (3,5-diiodosalicylic acid), 2-IBeA (2-iodobenzoic acid), 4-IBeA (4-iodobenzoic acid) and 2,3,5-triIBeA (2,3,5-triiodobenzoic acid). Only 2,3,5-triIBeA had a neg. influence on plant development. All organic iodine compounds were taken up by roots and transported to leaves and fruits. Among all the compounds applied, the most efficiently transferred iodine was 2-IBeA – to fruits, and 4-IBeA – to leaves. The order of iodine accumulation in fruit cell compartments was as follows: organelles > cell walls > soluble portions of cells; for leaf and root cells, it was: organelles > cell walls or soluble portions, depending on the compound applied. The compounds studied influence iodine metabolism through expression of the HMT gene which encodes halide ion methyltransferase in leaves and roots. Also, their influence on modification of the activity of the SAMT and S3H genes that encode salicylic acid carboxyl methyltransferase and salicylic acid 3-hydroxylase was established. It was discovered that exogenously applied 5-ISA, 3,5-diISA, 2-IBeA and 4-IBeA are genuinely (endogenously) synthesized in tomato plants; to date, this has not been described for the tomato, nor for any other species of higher plant. In the part of experimental materials, we found many familiar compounds, such as 2-Iodobenzoic acid(cas: 88-67-5SDS of cas: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.SDS of cas: 88-67-5Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Six 1-aroyl-4-(4-methoxyphenyl)piperazines: similar molecular structures but different patterns of supramolecular assembly》 were Kiran Kumar, Haruvegowda; Yathirajan, Hemmige S.; Sagar, Belakavadi K.; Foro, Sabine; Glidewell, Christopher. And the article was published in Acta Crystallographica, Section E: Crystallographic Communications in 2019. Recommanded Product: 2-Iodobenzoic acid The author mentioned the following in the article:

Six new 1-aroyl-4-(4-methoxyphenyl)piperazines have been prepared, using coupling reactions between benzoic acids and N-(4-methoxyphenyl)piperazine. There are no significant hydrogen bonds in the structure of 1-benzoyl-4-(4-methoxyphenyl)piperazine, C18H20N2O2, (I). The mols. of 1-(2-fluorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19FN2O2, (II), are linked by two C-H···O hydrogen bonds to form chains of rings, which are linked into sheets by an aromatic π-π stacking interaction. 1-(2-Chlorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19ClN2O2, (III), 1-(2-bromobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19BrN2O2, (IV), and 1-(2-iodobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19IN2O2, (V), are isomorphous, but in (III) the aroyl ring is disordered over two sets of at. sites having occupancies of 0.942 (2) and 0.058 (2). In each of (III)-(V), a combination of two C-H···π(arene) hydrogen bonds links the mols. into sheets. A single O-H···O hydrogen bond links the mols. of 1-(2-hydroxybenzoyl)-4-(4-methoxyphenyl)piperazine, C18H20N2O3, (VI), into simple chains. Comparisons are made with the structures of some related compounds In the part of experimental materials, we found many familiar compounds, such as 2-Iodobenzoic acid(cas: 88-67-5Recommanded Product: 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides.Recommanded Product: 2-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《The crystal structure of 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine: a three-dimensional hydrogen-bonded framework, augmented by π-π stacking interactions and I···N halogen bonds》 were Mahesha, Ninganayaka; Yathirajan, Hemmige S.; Furuya, Tetsundo; Akitsu, Takashiro; Glidewell, Christopher. And the article was published in Acta Crystallographica, Section E: Crystallographic Communications in 2019. Electric Literature of C7H5IO2 The author mentioned the following in the article:

In 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine, C15H15IN4O, the central piperazine ring adopts an almost perfect chair conformation with the pyrimidine substituent in an equatorial site. The planar amide unit makes a dihedral angle of 80.44 (7)° with the Ph ring. A combination of C-H···O and C-H···Π(arene) hydrogen bonds links the mols. into a complex three-dimensional network structure, augmented by a π-π stacking interaction and an I···N halogen bond, all involving different pairs of inversion-related mols. Comparisons are made with the structures of a number of related compounds In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Electric Literature of C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Electric Literature of C7H5IO2 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com