Formula: C7H5IO2In 2022 ,《Synthesis, characterization and anti-microbial screening of novel substituted thiadiazole-5-aminotetrazoles》 was published in Chemistry & Biology Interface. The article was written by Gaikwad, Mahadev; Gorepatil, Amarsinha; Gorepatil, Pratapsinha; Kadam, Vishal; Gaikwad, Shivshankar; Shinde, Vishnu; Ingle, Vilas. The article contains the following contents:
An efficient and green synthesis of substituted thiadiazole-5-aminotetrazoles I [R = Ph, benzyl, cinnamyl, etc.] were prepared in-situ by reaction of cyanogen bromide and sodium azide to generate a cyanogen azide as an intermediate in acetonitrile. The cyclization reaction of cyanogen azide and substituted thiadiazoles containing primary amines in acetonitrile-water solvent media, gave the intermediate 1-substituted 5-aminotetrazoles in good yield. In addition, to further evaluate the role of synthesized mols. for antimicrobial activities, and it’s found that compound I [R = 4-O2NC6H4, 2-IC6H4] showed a good antimicrobial for broad range of bacterial and fungal pathogens. After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C7H5IO2 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com