Category: 88-67-5

In 2019,Organic Letters included an article by Krishnamurti, Vinayak; Barrett, Colby; Ispizua-Rodriguez, Xanath; Coe, Matthew; Prakash, G. K. Surya. Application of 88-67-5. The article was titled 《Aqueous Base Promoted O-Difluoromethylation of Carboxylic Acids with TMSCF2Br: Bench-Top Access to Difluoromethyl Esters》. The information in the text is summarized as follows:

A method for the O-difluoromethylation of carboxylic acids using com. available TMSCF2Br is disclosed. The devised bench-top reaction system is air-stable and offers mild reaction conditions while using readily available reagents and solvents. The method is applicable to both aliphatic and aromatic carboxylic acids while demonstrating compatibility with a range of commonly encountered functional groups. The difluoromethyl esters of FDA approved drugs and pharmaceutically relevant mols. are also presented, demonstrating the potential for late-stage functionalization. The results came from multiple reactions, including the reaction of 2-Iodobenzoic acid(cas: 88-67-5Application of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides.Application of 88-67-5 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Photocatalytic Umpolung of N- and O-substituted alkenes for the synthesis of 1,2-amino alcohols and diols》 was written by Amos, Stephanie G. E.; Nicolai, Stefano; Waser, Jerome. Formula: C7H5IO2 And the article was included in Chemical Science in 2020. The article conveys some information:

An organophotocatalytic 1,2-oxyalkynylation of ene-carbamates and enol ethers using ethynyl benziodoxolones (EBXs). 1-alkynyl-1,2-amino alcs. and diols were obtained in up to 89% yield was reported. Photocatalytic formation of radical cations led to Umpolung of the innate reactivity of the alkenes, enabled addition of a nucleophilic benzoate followed by radical alkynylation.2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides.Formula: C7H5IO2 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Iodide as a Nucleophilic Trigger in Aryne Three-Component Coupling for the Synthesis of 2-Iodobenzyl Alcohols》 were Bhattacharjee, Subrata; Guin, Avishek; Gaykar, Rahul N.; Biju, Akkattu T.. And the article was published in Organic Letters in 2019. Recommanded Product: 88-67-5 The author mentioned the following in the article:

The synthetic potential of KI as the iodide source in aryne three-component coupling has been demonstrated using aldehydes as the third component. This mild and transition-metal-free coupling reaction allowed the straightforward synthesis of 2-iodobenzyl alcs. in moderate to good yields with good functional group compatibility. Moreover, KBr and KCl could be used as the nucleophilic trigger in this aryne multicomponent coupling (MCC) and N-methylisatin and CO2 could be used as the electrophilic third components.2-Iodobenzoic acid(cas: 88-67-5Recommanded Product: 88-67-5) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Recommanded Product: 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Crystal structure of 1-(2,4,6-trichlorobenzoyloxy) benzotriazole (TCB-OBt): observation of uncommon intermolecular oxygen-oxygen interaction and synthetic application in amidation》 was written by Dolai, Gobinda; Roy, Sayanta; Sen, Srijit; Giri, Rajat Subhra; Mandal, Bhubaneswar. Quality Control of 2-Iodobenzoic acidThis research focused ontrichlorobenzoyloxy benzotriazole preparation crystal structure; benzoic acid amine amidation; aryl amide preparation. The article conveys some information:

The supramol. assembly of a modified Yamaguchi reagent TCB-OBt was investigated. Interestingly, each mol. is interconnected through novel chalcogen-chalcogen (O···O) interaction, π-π stacking and aromatic C-H···O interaction. Hirshfeld surface anal. confirmed the existence of uncommon O···O interactions. A well-organized supramol. layer structure and helical arrangement were observed in the crystal structure. TCB-OBt crystallized in the O-substituted desmotropic form. DFT calculations suggest that the O-substituted form is more stable than the N-substituted form (TCB-(N)-OBt). Morphol. anal. indicates the formation of a fantastically well organized, continuous block-shaped system. Furthermore, the designed reagent works as an efficient activating reagent for amide bond formation with good yields under mild reaction conditions. Use of this reagent avoided intractable acid chlorides and this new mixed-anhydride-based reagent may further be applicable for many other organic transformations. In the part of experimental materials, we found many familiar compounds, such as 2-Iodobenzoic acid(cas: 88-67-5Quality Control of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Quality Control of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)》 was written by Brittain, William D. G.; Cobb, Steven L.. SDS of cas: 88-67-5 And the article was included in Organic Letters in 2021. The article conveys some information:

The present work describes the application of pentafluoropyridine (PFP), a cheap com. available reagent, in the deoxyfluorination of carboxylic acids RC(O)OH (R = Et, adamantan-1-yl, Ph, 2-iodophenyl, etc.) to acyl fluorides RC(O)F. The acyl fluorides can be formed from a range of acids under mild conditions. The PFP that can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides was also demonstrated. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides RC(O)N(R1)R2 (R1 = H, Me, Et; R2 = Et, Ph, 3-nitrophenyl, etc.) in yields of ≤94%. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5SDS of cas: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 88-67-5Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Copper-Catalyzed Modular Assembly of Polyheterocycles》 was written by Wang, Qian; Tuinhof, Jesse; Mgimpatsang, Kumchok C.; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Doemling, Alexander. Related Products of 88-67-5 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Easy operation, readily accessible starting materials, and short synthesis of the privileged scaffold indeno[1,2-c]isoquinolinones I (R1 = H, 3-MeO, 2-Me, 2-NO2, etc.; R2 = H, Me, cyclopentyl, 4-chlorophenyl, etc.; R3 = tert-Bu, benzyl, 2-methoxy-2-oxoethyl, 2-ethylphenyl, etc.; R4 = H, 8,9-dimethoxy) were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodol. allows an efficient construction of a wide variety of indenoisoquinolinones I in just two steps. The experimental process involved the reaction of 2-Iodobenzoic acid(cas: 88-67-5Related Products of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Unconventional Reactivity of Ethynylbenziodoxolone Reagents and Thiols: Scope and Mechanism》 was published in Chemistry – A European Journal in 2020. These research results belong to Liu, Bin; Alegre-Requena, Juan V.; Paton, Robert S.; Miyake, Garret M.. COA of Formula: C7H5IO2 The article mentions the following:

Herein, a general and efficient strategy utilizing ethynylbenziodoxolone (EBX) reagents I (R2 = t-Bu, C6H5, 4-FC6H4, etc.) and thiols is presented that results in the formation of 1,2-dithio-1-alkenes II (R1 = C6H5, c-hexyl, 2-pyridyl, etc.; R2 = C6H5, 3-MeOC6H4, 3-ClC6H4, etc.) with excellent regioselectivity and stereoselectivity through unprecedented reactivity between the EBX and the thiol. This operationally simple procedure utilizes mild conditions, which result in a broad substrate scope and high functional-group tolerance. The observed unexpected reactivity has been rationalized through both exptl. results and DFT calculations After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5COA of Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. COA of Formula: C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Electrochemical and spectroscopic study of 2-iodobenzoic acid and 2-iodosobenzoic acid anodic oxidation in aqueous environment》 was written by Devadas, Balamurugan; Svoboda, Jan; Krupicka, Martin; Bystron, Tomas. Computed Properties of C7H5IO2 And the article was included in Electrochimica Acta in 2020. The article conveys some information:

2-Iodosobenzoic acid and especially IBX represent interesting selective and green hypervalent I oxidants. Mainly due to issues connected with their preparation, use of these compounds is limited to laboratory scale. From this point of view, the electrochem. synthesis represents interesting platform for inherently safer production of these highly valued oxidants. To provoke and allow more intense study in this direction, this work aimed to present basic aspects of electrochem. behavior of these compounds in aqueous environment using several anode materials. A combination of various exptl. approaches in combination with time-dependent d. functional theory calculations allowed determining compounds speciation in a wide range of pH values. The most interesting in this sense is iodoxol ring opening after/during deprotonation of 2-iodosobenzoic acid to 2-iodosobenzoate. This process is accompanied by addition of H2O mol. to the I atom. Using voltammetry and controlled potential preparative batch electrolysis allowed constructing approx. form of Pourbaix diagram of the studied compounds Finally, diffusion coefficients of studied compounds and anodic charge transfer coefficients of oxidation reactions were determined based on detailed anal. of linear voltammograms. The results provide a solid base for further study of electrochem. synthesis of 2-iodosobenzoic acid and IBX in aqueous environment. After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Computed Properties of C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gollapelli, Krishna Kumar; Patil, Vaibhav B.; Vinaykumar, Allam; Chegondi, Rambabu published an article in 2021. The article was titled 《Rh(I)-catalyzed stereoselective desymmetrization of prochiral cyclohexadienones via highly exo-selective Huisgen-type [3 + 2] cycloaddition》, and you may find the article in Chemical Science.Synthetic Route of C7H5IO2 The information in the text is summarized as follows:

A Rh(I)-catalyzed highly stereoselective desymmetrization of 2-alkynylbenzaldehyde-tethered cyclohexadienones triggered by intramol. Huisgen-type [3 + 2] cycloaddition was developed. This method enables convergent construction of complex epoxy-bridged polycyclic ring systems with five contiguous stereocenters with excellent exo-selectivity and broad substrate scope. The highly atom-economical process involves 6-endo-dig cyclization of carbonyl oxygen onto an activated alkyne resulting in a highly reactive metal-benzopyrylium intermediate, which readily undergoes intramol. [3 + 2] annulation/hydration. Asym. induction was also achieved for the first time in Rh(I)-catalyzed 1,3-dipolar cycloaddition using an easily accessible chiral diene as the ligand. After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5Synthetic Route of C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Macromolecular Chemistry and Physics included an article by Cao, Yakun; Kumar, Rajesh; Tsarevsky, Nicolay V.. Product Details of 88-67-5. The article was titled 《Employing Heterocyclic Hypervalent Iodine Compounds with I-Cl Bonds as Initiators and Chain Transfer Agents in the Synthesis of Branched Polymers》. The information in the text is summarized as follows:

Heterocyclic hypervalent (HV) I(III) compounds with I-Cl bonds and various substituents at the N atom are synthesized and are very efficient chain transfer agents in the polymerization of styrene with transfer coefficients exceeding that of CCl4 by 2-3 orders of magnitude, depending on the structure. The chain transfer rate coefficients are also determined Due to the presence of thermally labile HV bonds, the compounds degrade homolytically upon heating and can initiate radical polymerization For instance, 1-chloro-2-hexyl-1,2-benziodazol-3(2H)-one, is used in the polymerization of styrene, which yields low mol. weight polymers with alkyl chloride groups at the α- (initiation) and the ω-chain ends (transfer). Chain-end functionalization reactions with azide and chain extension under low-catalyst-concentration atom transfer radical polymerization (ATRP) conditions of the prepared telechelic polymers are carried out. The same initiator/chain transfer agent is successfully employed in the synthesis of highly branched polymers with multiple alkyl chloride-type chain ends when added to mixtures of styrene and 1,4-divinylbenzene containing 10-80 mol% of the divinyl crosslinker, or even pure crosslinker. In all cases, soluble hyperbranched polymers are obtained up to moderate monomer conversions. The effects of crosslinker and HV I(III) compound concentrations on the polymerization outcome are studied systematically. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Product Details of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Product Details of 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com