Category: 869500-07-2

Reference of 869500-07-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 869500-07-2, name is 1-Bromo-2-iodo-3-methylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a souton of 5(4,455tetramethy-1 (nterrnedafte28, 250 mg, 0.96 mmo), potassum phosphate (408 mg, 1.9 mmo), and 1-bromo–2odo3 methybenzene (342 mg, 1.1 mmo) ri 4:1 doxane:water (6.6 mL) was added PdC2(dppf)- CH2C2 (35 mg, 0.05 mmo) at once. The mixture was degassed with n[trogen for 10 minutes and then heated at 100 C for 16 h. After coong to rt, the reacUon nixture was duted w[th water and extracted with DCM (x3). The combned organc extracts were dried(NaSO), fl[tered and concentrated under reduced pressure. The crude product was purfled by flash coumn chromatography (SO2; 0 5% DCM/MeOH) to provide the tWe compound as a wh[te sod (98 mg, 34% yed).. MS (ES): mass cacd. for C14H11BrN2O, 3020; m/zfound, 303.1 [M+Hj. 1H NMR (400 MHz, DMSOd6) oe 1069 (s, IH), 10.65 (5, 1H), 7.53 (dt, J= 8.0, 0.9 Hz, IH), 7.30(dt, J= 7.5, 1.1 Hz, IH), 7.23-7.12 (m, 1H), 6.99(d, J = 7.9 Hz, 1 H), 6.73 6.61 (m, 2H), 2.04 (s, 3H).

The synthetic route of 1-Bromo-2-iodo-3-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 869500-07-2, name is 1-Bromo-2-iodo-3-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 869500-07-2, name: 1-Bromo-2-iodo-3-methylbenzene

A mixture of 1-bromo-2-iodo-3-methylbenzene (0.46g), {3-[(ethyloxy)- carbonyl] phenyl}boronic acid (0.20g), tetrakis(triphenylphosphine)palladium(0) (60mg), potassium carbonate (0.71g), toluene (6ml) and ethanol (6ml) was stirred under reflux under nitrogen for 3h. The mixture was partitioned between water (40ml) and ether (40ml) and the aqueous layer extracted with ether (15ml). The combined ether extracts were dried (MgS04), evaporated and the residue purified by flash chromatography eluting with 2% ethyl acetate in isohexane to afford the title compound (0.22g). LC/MS Rt = 4.1 min, [MH+] 319/321.

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Reference:
Patent; GLAXO GROUP LIMITED; WO2005/108369; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 869500-07-2 as follows. Formula: C7H6BrI

29.7 g of 1-bromo-2-iodo-3-toluene was dissolved in 300 ml of 1,4-dioxane solvent.Stirring under nitrogen, adding 20.2 g of o-bromobenzeneboronic acid,34.5 g of K2CO3, 1.15 g of tetrakis(triphenylphosphine)palladium, and the temperature was raised to reflux.After 5 hours, the basic reaction of the raw materials was determined by HPLC, and the reaction solution was dried under reduced pressure.The residue was subjected to column chromatography to give Intermediate 22-1 as 22.1 g (0.068 mol). (Yield: 81%)

According to the analysis of related databases, 869500-07-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Lv Ren Science And Technology Co., Ltd.; Lv Yao; Feng Yu; Jia Xueyi; (40 pag.)CN108409773; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com