Category: 85356-68-9

One-Pot Preparation of Alkyl Iodides from Esters by Indium-Catalyzed Reductive Cleavage of a Carbon-Oxygen Bond was written by Sakai, Norio;Matsushita, Yohei;Konakahara, Takeo;Ogiwara, Yohei;Hirano, Keisuke. And the article was included in European Journal of Organic Chemistry in 2015.Category: iodides-buliding-blocks This article mentions the following:

The indium-catalyzed reductive iodination of aliphatic and aromatic esters with iodine and 1,1,3,3-tetramethyldisiloxane (TMDS) was described. The reducing procedure accommodates a variety of esters, including esters containing alkyl groups, halogens, a hydroxy group, a thioether, and an alkene moiety. This procedure was applied to the cleavage of carbon-oxygen bonds in acrylate polymers. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Category: iodides-buliding-blocks).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Visible-Light-Driven Conversion of Alcohols into Iodide Derivatives with Iodoform was written by Zhao, Yubao;Antonietti, Markus. And the article was included in ChemPhotoChem in 2018.Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene This article mentions the following:

A mild, cost effective, operationally simple and environmentally benign visible-light-driven alc. iodination reaction system for the synthesis of iodoalkanes was developed. In this reaction system, visible light and iodoform were employed as the energy source and iodination reagent, resp. The reaction begins with the homolytic fission of the C-I bond in iodoform induced by visible-light irradiation, produced active radicals. The following steps involved as radical trapping by DMF, nucleophilic substitution, Vilsmeier-type reagent formation, and the final iodination of the alc. The excellent performance of the model reaction in the flow photoreactor demonstrated the potential of this system for practical application. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application In Synthesis of 1-Bromo-4-(2-iodoethyl)benzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Convergent Synthesis of Immune Inhibitor IMMH002 was written by Chen, Si;Shi, Zeyu;Xiao, Qiong;Yin, Dali. And the article was included in Synthesis in 2021.Computed Properties of C8H8BrI This article mentions the following:

A convergent synthesis of IMMH002 in 36% overall yield starting from bromobenzene was described with a key Suzuki-Miyaura cross-coupling reaction used to provide a crucial intermediate. The route does not require column chromatog. and solves the most intractable quality problem caused by a homolog byproduct in the original linear synthesis. Furthermore, reducing the use of Lewis acid mediated reactions improves the environmental impact of the synthesis and reduces overall waste. The new route described herein was more efficient, convenient, reliable, and economically more viable when compared to the previously reported linear route. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Computed Properties of C8H8BrI).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Computed Properties of C8H8BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com