Category: 847685-01-2

Synthetic Route of 847685-01-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

16.1 (4-Chloro-phenyl)-(4,5-difluoro-2-iodo-phenyl)-diazene; Chloro-4-nitroso-benzene (9.1 g, 64 mmol; [932-98-9]) was added to a solution of 4,5-difluoro-2-iodo-phenylamine (10.9 g, 43 mmol; [847685-01-2]) in acetic acid (430 ml). The reaction mixture was heated under reflux conditions for 14 h. Ice water (1 1) and EtOAc (1 1) was added, the layers were separated and the aqueous layer was extracted two times with EtOAc. The combined extracts were washed with water and brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography (silica gel, CH2Cl2/heptane) to give the title compound (4.34 g, 11 mmol; 27%) as orange solid. MS: m/e=377.9 [M+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Difluoro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Benson, Gregory Martin; Bleicher, Konrad; Feng, Song; Grether, Uwe; Kuhn, Bernd; Martin, Rainer E.; Plancher, Jean-Marc; Richter, Hans; Rudolph, Markus; Taylor, Sven; US2010/76026; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 847685-01-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of aniline 1(2 mmol) and alkyne 2 (3 mmol) in MeCN (12 mL) were added Pd(PPh3)2Cl2 (56 mg, 0.08 mmol), CuI (34 mg,0.18 mmol) and Et3N (3 mL) at room temperature under an argon atmosphere. The reaction mixture was stirred at 60 C for 2 h. After the mixture was cooled to room temperature, diluted with CH2Cl2(10 mL), poured into H2O (40 mL) and extracted with CH2Cl2(3 × 50 mL). The combined organic layers were washed with H2O (30mL) and dried (MgSO4). After evaporation of the solvent in vacuo,the crude product 3 was obtained (the 1H and19FNMR spectra closely agree with the literature data [2]) and used further without purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Difluoro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Politanskaya, Larisa; Shteingarts, Vitalij; Tretyakov, Evgeny; Potapov, Alexander; Tetrahedron Letters; vol. 56; 39; (2015); p. 5328 – 5332;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, molecular formula is C6H4F2IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4,5-Difluoro-2-iodoaniline

A dark violet solution of 2-iodo-4,5-difluoroaniline (1a) (148 mg, 0.582 mmol), gold complex [AuPPh3NN] 2 (308 mg, 0.5 mmol),[Pd(PPh3)4] (52 mg, 0.045 mmol) in 7 ml of acetonitrile were stirred in an argon atmosphere at 60-65 C for 1 h. The reaction mixture was evaporated. The product was isolated by column chromatography on SiO2, using a mixture of methylenechloride with ethylacetate (3:1) as the eluent. Yield: 71 mg (50%), dark purple crystals, Tmelt = 140-141 C. UV spectrum(CH2Cl2), lambdamax, nm (lgepsilon): 240 (4.00), 260 (3.79), 346 (4.07), 578 (2.88). IR spectrum (KBr), v , cm-1: 3357, 3168 (NH2), 2996(C-H), 1646, 1592, 1502, 1355, 1143, 873, 788. Found, %: 55.07, 5.63, N 14.64. Calculated, %: 54.93, 5.63, N14.78.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 847685-01-2, its application will become more common.

Reference:
Article; Tretyakov; Makhneva; Politanskaya; Bagryanskaya, I. Yu.; Stass; Journal of Structural Chemistry; vol. 59; 3; (2018); p. 689 – 696; Zh. Strukt. Kim.; vol. 59; 3; (2018); p. 712 – 719,8;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 847685-01-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

16.1 (4-Chloro-phenyl)-(4,5-difluoro-2-iodo-phenyl)-diazene; Chloro-4-nitroso-benzene (9.1 g, 64 mmol; [932-98-9]) was added to a solution of 4,5-difluoro-2-iodo-phenylamine (10.9 g, 43 mmol; [847685-01-2]) in acetic acid (430 ml). The reaction mixture was heated under reflux conditions for 14 h. Ice water (1 1) and EtOAc (1 1) was added, the layers were separated and the aqueous layer was extracted two times with EtOAc. The combined extracts were washed with water and brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography (silica gel, CH2Cl2/heptane) to give the title compound (4.34 g, 11 mmol; 27%) as orange solid. MS: m/e=377.9 [M+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Difluoro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Benson, Gregory Martin; Bleicher, Konrad; Feng, Song; Grether, Uwe; Kuhn, Bernd; Martin, Rainer E.; Plancher, Jean-Marc; Richter, Hans; Rudolph, Markus; Taylor, Sven; US2010/76026; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 847685-01-2, Recommanded Product: 847685-01-2

General procedure for the synthesis of lH-indole-2-carboxylic acid AA mixture of the appropriate ort/zo-iodoaniline (5 mmol), pyruvic acid (1.04 mL, 15 mmol), DABCO (1.683 g, 15 mmol) and Pd(OAc)2 (56 mg, 0.25 mmol) in dry DMF (15 mL) was degassed 3 times and then was stirred at 105C for 16 h. The mixture was cooled to room temperature, neutralized with 10% aqueous hydrochloric acid and extracted with EtOAc (3×15 mL). The combined organic phases were washed with brine, dried over anhydrous Na2S04, filtered and concentrated in vacuo. The crude product was purified by flash column chromatography using 95/5 EtOAc/MeOH and recrystallized from EtOH to yield the IH- indole-2-carboxylic acid.5,6-difluoro-l//-indoIe-2-carboxylic acid Al Yield = 43%, pale grey powder. Mp = 292-293C. NMR (600 MHz, DMSO-c/6): delta 13.11 (bs, 1H), 11.97 (bs, 1H), 7.66 (dd, J = 10.8 Hz, 8.4 Hz, 1H), 7.33 (dd, J = 10.8 Hz, 6.6 Hz, 1H), 7.09 (d, J= 1.2 Hz, 1H). 13C NMR (150 MHz, CDC13 + DMSO-^): delta 162.5, 148.9 (dd, J = 242 Hz, 16 Hz), 146.2 (dd, J = 237 Hz, 16 Hz), 132.3 (d, J – 11 Hz), 129.5 (d, J = 4 Hz), 121.8 (d, J= 8 Hz), 107.4, 107.3 (d, J= 19 Hz), 99.5 (d, J= 22 Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,5-Difluoro-2-iodoaniline, and friends who are interested can also refer to it.

Reference:
Patent; THE UNIVERSITY OF BRITISH COLUMBIA; SIMON FRASER UNIVERSITY; REINER, Neil E.; FINLAY, Barton B.; BRUNHAM, Robert C.; TCHERKASSOV, Artem; FOSTER, Leonard J.; MCMASTER, William R.; SEE, Raymond H.; ZORAGHI, Roya; HSING, Michael M. K.; BYLER, Kendall G.; AXERIO-CILIES, Peter J.; BAN, Fuqiang; KUMAR, Nag; MOREAU, Anne; LABRIERE, Christophe; YOUNG, Robert N.; WO2012/51708; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, A new synthetic method of this compound is introduced below., SDS of cas: 847685-01-2

General procedure: To a stirred mixture of aniline 2b (0.100 g, 0.344 mmol), hex-1-yne 3g (0.084 g, 1.031 mmol) and Et3N (3 mL) under argon added were Pd(PPh3)2Cl2 (0.010 g, 0.014 mmol), CuI (0.006 g, 0.031 mmol) and, additionally, Et3N (3 mL). Stirring was continued at 70 C for 3 h, the mixture was cooled to r.t., diluted by CHCl3 (10 mL) and poured into a mixture of H2O (30 mL) and CHCl3 (20 mL). The aqueous layer was extracted with CHCl3 (2 × 30 mL), the collected organic solution was washed with H2O (3 × 30 mL) and dried (MgSO4). Evoparation of the solvent and chromatography (TLC) of the crude product (eluent: hexane-EtOAc, 10:1 ? 10:1 ? 10:1, Rf = 0.54) gave aniline 4bg (0.067 g, 80%) as an oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Politanskaya, Larisa V.; Chuikov, Igor P.; Kolodina, Ekaterina A.; Shvartsberg, Mark S.; Shteingarts, Vitalij D.; Journal of Fluorine Chemistry; vol. 135; (2012); p. 97 – 107;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, A new synthetic method of this compound is introduced below., Quality Control of 4,5-Difluoro-2-iodoaniline

4,5-Difluoro-2-iodoaniline (Intermediate 27, 1.24 g, 4.86 mmol) was dissolved in anhydrous DMF (15 mL). Pyruvic acid (1.32 g, 15 mmol) and DABCO (1.68 g, 15 mmol) were added and the mixture degassed by alternate vacuum and nitrogen purge. Palladium EPO acetate (56 mg) was then added and the mixture heated to 1000C. for 2h. After cooling to ambient temperature the reaction mixture was filtered through celite, diluted with ethyl acetate (10OmL), washed with 2M HCl (2x 2OmL) and water (2x 2OmL), dried (MgSO4) and evaporated to give the title compound as a dark solid (860 mg, 90%). 1H NMR delta: 7.0 (s, IH), 7.3 (dd, IH), 7.6 (dd, IH), 11.9 (s, IH); MS m/z 196 (m-H)

The synthetic route of 847685-01-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/82400; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

847685-01-2, name is 4,5-Difluoro-2-iodoaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H4F2IN

General procedure: Pd(PPh3)2Cl2 (28 mg, 0.04 mmol), CuI (17 mg, 0.09 mmol) and Et3N (3mL) were added to a stirred solution of iodoaniline 2(b-f) or 2-iodoaniline (7) (1 mmol), 2-methylbut-3-yn-2-ol (126 mg, 1.5 mmol) in dry MeCN (10mL) at room temperature under an argon atmosphere. The mixture was heated at 50C for 2 h with stirring. The reaction mixture was allowed to cool down to room temperature, and CH2Cl2 (10 mL) was added. The mixture was poured into H2O (40 mL) and extracted with CH2Cl2 (3× 50mL). The combined organic layers were washed with H2O (40 mL) and dried (MgSO4). The evaporation of the solvent in vacuo gave the crude product 3(b-f) or 4-(2-aminophenyl)-2-methylbut-3-yn-2-ol (8) that was used without further purification (the 1H and 19F NMR spectra agreed with the literature data [11,12]).

The synthetic route of 847685-01-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Politanskaya, Larisa V.; Chuikov, Igor P.; Tretyakov, Evgeny V.; Shteingarts, Vitalij D.; Ovchinnikova, Ludmila P.; Zakharova, Olga D.; Nevinsky, Georgy A.; Journal of Fluorine Chemistry; vol. 178; (2015); p. 142 – 153;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 847685-01-2, A common heterocyclic compound, 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, molecular formula is C6H4F2IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a two-necked round-bottomed flask fitted with a guard tube, PBr3 (2.7mmol, 0.26 mL), DMF (3 mmol, 0.23 mL) and chloroform (0.80 mL) were added, allowed to cool to 0 C and stirred for 0.5 h. After formation of colourless solid complex, 2-Iodo-4-methyl-phenylamine 2b (1 mmol) in chloroform (5 mL) was added and the reaction mixture was allowed to stir at r.t. for another 1-2 h. After completion, the reaction mixture was neutralized by adding saturated NaHCO3 solution and then extracted with DCM (3X 20 mL). Combined organic layer was washed with brine and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was purified through column chromatography using silica gel (60-120 mesh) and petether/EtOAc (5:1) as eluent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ghosh, Munmun; Ahmed, Atiur; Singha, Raju; Ray, Jayanta K.; Tetrahedron Letters; vol. 56; 2; (2015); p. 353 – 355;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H4F2IN

General procedure: To a solution of iodoaniline 2 (5.00 mmol) and ethynyltrimethylsilane (1.47 g, 15.00 mmol) in Et3N (10 mL) in a Schlenk flask under argon were added Pd(PPh3)2Cl2 (175 mg, 0.25 mmol) and CuI (95 mg, 1.50mmol). The reaction mixture was heated at 40 C for the required period (Table 1) with stirring. Then, the mixture was diluted with CH2Cl2(10 mL). The suspension was placed directly onto a chromatography plate (silica gel) and air-dried. The trimethylsilanyl ethynylanilines 3 were isolated by TLC using EtOAc/hexane as the eluent. 4,5-Difluoro-2-[(trimethylsilyl)ethynyl]aniline (3a) Brown oil; yield: 1.00 g (89%); Rf = 0.56 (EtOAc/hexane, 1:7). IR (neat): 3485, 3388, 2960, 2901, 2148, 1628, 1599, 1516, 1437, 1348, 1298, 1252, 1227, 1182, 1122, 870, 845, 762, 629 cm-1. 1H NMR (300 MHz, acetone-d6): delta = 7.07 [dd, J (H3,F4) = 10.8 Hz, J (H3,F5) = 8.8 Hz, 1 H, H3], 6.63 [dd, J (H6,F5) = 12.7 Hz, J (H6,F4) = 7.1 Hz, 1 H, H6], 5.01 (s, 2 H, NH2), 0.26 (s, 9 H, CH3). 13C NMR (100 MHz, acetone-d6): delta = 152.0 [dd, 1J (C5,F5) = 247.3 Hz, 2J (C5,F4) = 13.8 Hz, C5], 147.9 [d, 3J (C1,F5) = 10.0 Hz, C1], 142.3 [dd,1J (C4,F4) = 235.5 Hz, 2J (C4,F5) = 13.9 Hz, C4], 120.1 [dd, 2J (C3,F4) = 19.0 Hz, 3J (C3,F5) = 2.0 Hz, C3], 103.1 [m, 3J (C2,F4) = 7.2 Hz, C2], 102.8 [d, 2J (C6,F5) = 21.0 Hz, C6], 103.1 (m, C?C), 100.3 (m, C?C), 0.0 (s, CH3). 19F NMR (282 MHz, acetone-d6): delta = -134.4 [ddd, J (F5,F4) = 22 Hz, J (F5,H6) = 12.7 Hz, J (F5,H3) = 8.8 Hz, 1 F, F5], -153.2 [ddd, J (F4,F5) = 22.4 Hz, J (F4,H3) = 10.8 Hz, J (F4,H6) = 7.1 Hz, 1 F, F4]. HRMS (EI): m/z [M]+ calcd for C11H13F2NSi: 225.0780; found: 225.0781.

According to the analysis of related databases, 847685-01-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Politanskaya, Larisa; Tretyakov, Evgeny; Synthesis; vol. 50; 3; (2018); p. 555 – 564;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com