Category: 83863-33-6

83863-33-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83863-33-6, name is 5-Iodo-2-methylaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Referential Example 9 2.1 mL of benzoyl chloride was added to 70 mL of a methylene chloride solution containing 3.5 g of 5-iodo-2-methylaniline and 2.5 mL of triethylamine at room temperature and stirred at the same temperature for 30 minutes. 1.0 mol/L hydrochloric acid was added to the reaction mixture. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium hydrogen carbonate aqueous solution, and the solvent was evaporated under reduced pressure. Diisopropyl ether and hexane were added to the obtained residue and a solid substance was separated by filtration to obtain 4.2 g of N-(5-iodo-2-methylphenyl)benzamide as pale yellow solid. 1H-NMR (CDCl3) delta: 2.29 (3H, s), 6.96 (1H, d, J = 8.0 Hz), 7.44 (1H, dd, J = 1.6, 8.0 Hz), 7.49-7.63 (4H, m), 7.86-7.88 (2H, m), 8.39 (1H, d, J = 1.6 Hz).

The synthetic route of 83863-33-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TOYAMA CHEMICAL CO., LTD.; EP1820795; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

83863-33-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 83863-33-6, name is 5-Iodo-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.

PREPARATION 21 N-(4-Iodo-2-methylphenyl)acetamide In the manner of Preparation 5, 10 g (0.043 mol) of 5-iodo-2-methylaniline was converted into the title compound: yield 11.1 g (94%); m.p. 182-183 C. Analysis calculated for C9 H10 INO: C, 39.29; H, 3.66; N, 5.09%. Found: C, 39.61; H, 3.77; N, 4.96%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Pfizer Inc.; US4762838; (1988); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 83863-33-6, name is 5-Iodo-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., 83863-33-6

Step A N-(5-iodo-2-methylphenyl)iminodiacetic acid diethyl ester Using 5-iodo-2-methylaniline (4.66 g, 20 mmol) and according to the method of Reference Example 61, step C, the title compound (8.31 g, yield>100%) was obtained as a pale-yellow oil. 1H-NMR (400 MHz, DMSO-d6); delta(ppm) 1.15 (t, J=7.1, 6H), 2.20 (s, 3H), 3.98 (s, 4H), 4.06 (q, J=7.1, 4H), 6.93 (d, J=8.0, 1H), 7.28 (dd, J=7.9, 1.5, 1H), 7.39 (d, J=1.4, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; US2012/196824; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com