Category: 83410-16-6

Safety of 4-Chloro-5-iodo-2,6-dimethylpyrimidineOn October 22, 1998 ,《Metabolites of the Angiotensin II Antagonist Tasosartan: The Importance of a Second Acidic Group》 was published in Journal of Medicinal Chemistry. The article was written by Ellingboe, John W.; Collini, Michael D.; Quagliato, Dominick; Chen, James; Antane, Madelene; Schmid, Jean; Hartupee, Dale; White, Valerie; Park, C. Hyung; Tanikella, Tarak; Bagli, Jehan F.. The article contains the following contents:

Described in this paper is the synthesis and pharmacol. activity of five metabolites of the angiotensin II antagonist tasosartan (1). Of particular interest is the effect of the addnl. acidic group of the enol metabolite (8) on activity. As suggested by the structural-activity relationship of other angiotensin II antagonist series, a second acidic group can improve receptor binding activity but decrease in vivo activity after oral dosing. The metabolic introduction of a second acidic group in tasosartan bypasses this problem and contributes to the excellent profile of the compound A mol. modeling study provides a rationale for the role of the enol group of 8 in AT1 receptor binding. The experimental process involved the reaction of 4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6Safety of 4-Chloro-5-iodo-2,6-dimethylpyrimidine)

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 4-Chloro-5-iodo-2,6-dimethylpyrimidine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sakamoto, Takao; Kondo, Yoshinori; Watanabe, Ryo; Yamanaka, Hiroshi published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Condensed heteroaromatic ring systems. VII. Synthesis of thienopyridines, thienopyrimidines, and furopyridines from o-substituted N-heteroarylacetylenes》.COA of Formula: C6H6ClIN2 The author mentioned the following in the article:

Alkynylation of iodopyrimidines I (R = H, Me, Me2CH, MeS; R1 = H, Me, OMe; R2 = H) with Me3SiCCH gave 70-83% I (R2 = CCSiMe3), which were cyclized with NaSH to give 53-95% 8 thienopyrimidines II. In addition to this study using 4-Chloro-5-iodo-2,6-dimethylpyrimidine, there are many other studies that have used 4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6COA of Formula: C6H6ClIN2) was used in this study.

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C6H6ClIN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 83410-16-6On October 25, 1982 ,《Studies on pyrimidine derivatives. XXX. The palladium-catalyzed cross-coupling reactions of iodopyrimidines with terminal olefinic compounds》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Sakamoto, Takao; Arakida, Hiroko; Edo, Kiyoto; Yamanaka, Hiroshi. The article contains the following contents:

The influence of Ph3P, used as a ligand, on the palladium-catalyzed cross-coupling reactions of iodopyrimidines with olefins such as H2C:CHCO2Et, H2C:CHCN, H2C:CHPh was investigated. The effect of Ph3P in the monoazine series is also discussed. Thus, coupling of 2-iodo-4,6-dimethylpyrimidine with N2C:CHCO2Et in presence of Pd(OAc)2 gave 57% pyrimidine I. Using Pd(OAc)2-2Ph3P as a catalyst gave no I.4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6Recommanded Product: 83410-16-6) was used in this study.

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 83410-16-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of Pyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines by a One-Pot C-N-Coupling/Hydroamination/C-H-Arylation Sequence》 were Ngo, Nghia Pham; Ali Salman, Ghazwan; Belattar, Nadjah; Tuan, Thanh Dang; Ehlers, Peter; Langer, Peter. And the article was published in European Journal of Organic Chemistry in 2017. Product Details of 83410-16-6 The author mentioned the following in the article:

A modular and atom-economic synthetic pathway towards 11,13-dimethylpyrimido[5′,4′:4,5]pyrrolo[1,2-f]phenanthridines is described. The protocol features a chemoselective Sonogashira reaction of a 4,5-dihalopyrimidine followed by a domino C-N coupling/hydroamination and C-H arylation that can be achieved in a one-pot process. The yields vary from moderate to good.4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6Product Details of 83410-16-6) was used in this study.

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 83410-16-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com