Category: 83027-73-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83027-73-0, name is 5-Bromo-1-chloro-3-fluoro-2-iodobenzene, A new synthetic method of this compound is introduced below., Quality Control of 5-Bromo-1-chloro-3-fluoro-2-iodobenzene

Dry methanol (160 mL) was cooled to 10 C and potassium hydroxide (14.9 g) was added portion wise over 25 minutes. Once dissolved, this solution was added over 15 minutes to a refluxing solution of 5-bromo-1-chloro-3-fluoro-2-iodo-benzene (CAS 83027-73-0, 40.0 g) in dry methanol (320 mL). After 46 hours refluxing the reaction mixture was concentrated and partitioned between water (500 mL) and ethyl acetate (500 mL). The aqueous phase was extracted with further ethyl acetate (2 x 200 mL). The combined organic layers were washed with brine (400 mL), dried over magnesium sulfate, concentrated and purified by chromatography on silica eluting with ethyl acetate in iso-hexane to give 5-bromo-1-chloro-2- iodo-3-methoxy-benzene (37.767 g) as a pale pink solid 1H NMR (500 MHz, CDCI3) 7.28 (d, 1 H), 6.82 (d, 1 H), 3.90 (s, 3H).

The synthetic route of 83027-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA LIMITED; MOUND, William Roderick; SCUTT, James Nicholas; SLATER, Mark; WILLETTS, Nigel James; WO2014/96289; (2014); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 83027-73-0, These common heterocyclic compound, 83027-73-0, name is 5-Bromo-1-chloro-3-fluoro-2-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dry methanol (160ml_) was cooled to 10 C and potassium hydroxide (14.9g) was added portionwise over 25 minutes. Once dissolved, this solution was added over 15 minutes to a refluxing solution of 5-bromo-1-chloro-3-fluoro-2-iodo-benzene (CAS Reg. No. 83027-73-0, 40.0 g) in dry methanol (320ml_). After 46 hours refluxing the reaction mixture was concentrated and partitioned between water (500ml_) and ethyl acetate (500ml_). The aqueous phase was extracted with further ethyl acetate (2 x 200ml_). The combined organic layers were washed with brine (400ml_), dried over magnesium sulfate, concentrated and purified by chromatography on silica eluting with ethyl acetate in iso-hexane to give 5-bromo- 1 -chloro-2-iodo-3-methoxy-benzene (37.767g) as a pale pink solid. 1H NMR (500 MHz, CDCI3) delta (delta) 7.28 (d, 1 H), 6.82 (d, 1 H), 3.90 (s, 3H)

The synthetic route of 83027-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SYNGENTA LIMITED; HACHISU, Shuji; SCUTT, James Nicholas; WILLETTS, Nigel James; WO2015/32702; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83027-73-0, name is 5-Bromo-1-chloro-3-fluoro-2-iodobenzene, A new synthetic method of this compound is introduced below., name: 5-Bromo-1-chloro-3-fluoro-2-iodobenzene

Dry methanol (160 mL) was cooled to 10 C and potassium hydroxide (14.9 g) was added portion wise over 25 minutes. Once dissolved, this solution was added over 15 minutes to a refluxing solution of 5-bromo-1-chloro-3-fluoro-2-iodo-benzene (CAS 83027-73-0, 40.0 g) in dry methanol (320 mL). After 46 hours refluxing the reaction mixture was concentrated and partitioned between water (500 mL) and ethyl acetate (500 mL). The aqueous phase was extracted with further ethyl acetate (2 x 200 mL). The combined organic layers were washed with brine (400 mL), dried over magnesium sulfate, concentrated and purified by chromatography on silica eluting with ethyl acetate in iso-hexane to give 5-bromo-1-chloro-2- iodo-3-methoxy-benzene (37.767 g) as a pale pink solid 1H NMR (500 MHz, CDCI3) 7.28 (d, 1 H), 6.82 (d, 1 H), 3.90 (s, 3H).

The synthetic route of 83027-73-0 has been constantly updated, and we look forward to future research findings.