Category: 825-98-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 825-98-9, name is 3-Fluoro-4-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H4FIO2

To a solution of 3-fluoro-4-iodobenzoic acid (step-lof Intennediate-27, 1.0 g, 3.75 mmol) inDCM (20.0 mL) was added oxalyl chloride (947 mg, 7.57 mmol) and stirred at ft for 3-4 h.Meanwhile, to a solution of 2-(dimethylamino)ethanol (501 mg, 5.63 mmol) in THF (20.0 mL)was added Et3N (759 mg, 7.51 mmol) and stirred for 5-10 mins followed by addition of aboveprepared acid chloride solution. The reaction mass was stirred at rt for 16 h before it wasquenched with water and extracted with DCM. The organic layer was concentrated to afford400 mg of title product. ?H NMR (300 MHz, DMSO-d6): 10.54 (br s, 1H), 8.08-8.03 (t, J =7.8 Hz, 1H), 7.95-7.91 (d, J = 9.3 Hz, 1H), 7.68-7.66 (m, 1H), 4.59 (t, 2H), 3.50 (br s, 2H),2.84 (s, 6H); MS [M+Hj: 338.

According to the analysis of related databases, 825-98-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; PISAL, Dnyandeo; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; KADAM, Sheetal R; (303 pag.)WO2016/55947; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 825-98-9, name is 3-Fluoro-4-iodobenzoic acid, A new synthetic method of this compound is introduced below., name: 3-Fluoro-4-iodobenzoic acid

To a solution of 3-fluoro-4-iodobenzoic acid (step-iof Intermediate-27, i.0 g, 3.75 mmol) inDMF (iO mL) was added K2C03 (i.07 g, 7.5i mmol), 2-bromo-N,N-diethylacetamide (i.09 g,5.63 mmol).The reaction mass was stirred at 80-90C for i6 h. The reaction mixture wasquenched with water, extracted with DCM. The organic layers were dried over Na2504 and concentrated to afford 0.500 g of title compound. ?H NMR (300 MHz, DMSO-d6): 8.09- 8.04 (t, J = 6.6 Hz, iH), 7.73-7.70 (t, J = 8.i Hz, iH), 7.60-7.57 (t, J = 7.8 Hz, iH), 5.03 (s, 2H), 3.30-3.i9 (q, J= 7.5 Hz, 4H), i.i7-i.i3 (t, J= 7.5 Hz, 3H), i.04-0.99 (t, J= 7.2 Hz, 3H);MS [M+Hf?: 380.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.