Cottet, Fabrice; Schlosser, Manfred published their research in Tetrahedron on December 13 ,2004. The article was titled 《Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids》.Recommanded Product: 823221-97-2 The article contains the following contents:
Although there are many conceivable ways to functionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only 2-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid from this precursor and 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl)pyridine into only the 4- and 6-carboxylic acids and to make the 3-carboxylic acid from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. The experimental process involved the reaction of 3-Bromo-5-chloro-2-iodopyridine(cas: 823221-97-2Recommanded Product: 823221-97-2)
3-Bromo-5-chloro-2-iodopyridine(cas: 823221-97-2) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 823221-97-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com