Category: 7681-82-5

These common heterocyclic compound, 7681-82-5, name is Sodium iodide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 7681-82-5

Synthesis of 47; A Schlenk tube was charged with complex 46 (67.7 mg, 0.17 mmol), Nal (509.7 mg, 3.4 mmol), and 5 mL of THF. The reaction mixture was stirred at room temperature for 8 h. The solvent was removed under vacuum. The residue was dissolved in toluene, and the resulting suspension was passed through a plug of Celite. All the volatiles were removed, and the residue was washed with diethyl ether (3 x 5 mL) to give 47 as a dark red powder. Yield: 70% (69.8 mg, 0.12 mmol).1H NMR (CD2C12, 400 MHz): delta 7.08 (s, 2H,CHimid), 5.59 (d, J=5.60 Hz, 2H, CHpcym), 5.18 (d, J = 5.56 Hz, 2H, CHpcym), 4.04 (s, 6H, CH3imid), 3.15 (septet, J = 6.88 Hz, 1H, CHisop pcym), 1.96 (s, 3H, CH3pcym), 1.23 (d, J=6.88 Hz, 6H, CH3isop pcym).13C NMR (CD2C12, 100MHz): delta 170.4 (C-Ru), 124.4 (CH^a), 110.0 (Cqpcym), 99.9(Cqpcym), 86.6 (CHpcym), 83.0 (CHpcym), 44.9 32.0 (CHisop pcym), 23.0 (CH3is0p pCym),-19.2 (CH3pcym).Anal, calcd for C16H24Cl2I2N2Ru (47 3CH2C12, 670.2): C, 28.68; H, 3.61; N, 4.18. Found: C, 28.41; H, 3.89; N, 4.33

The synthetic route of Sodium iodide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NANYANG TECHNOLOGICAL UNIVERSITY; HONG, Soon Hyeok; GHOSH, Subhash Chandra; ZHANG, Yao; MUTHAIAH, Senthilkumar; CHEN, Cheng; XU, Xiangya; WO2011/34506; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 7681-82-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7681-82-5, name is Sodium iodide, This compound has unique chemical properties. The synthetic route is as follows.

PdCl2 (PPh3) 2 (50 mg, 0.071 mmol),NaI (107 mg, 0.71 mmol),10 mL of dichloromethane,And 10 mL of water were sequentially added to a 50 mL round bottom flask,The reaction was stirred at room temperature for 8 hours and the organic layer was separated,Dried over anhydrous sodium sulfate,Filter concentrate,The crude product was recrystallized from dichloromethane / petroleum ether to give red crystals as PdI2 (PPH3) 2 complex,Yield: 90%.

The chemical industry reduces the impact on the environment during synthesis Sodium iodide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tianjin Normal University; Liu, Guiyan; Liu, Chengxin; (7 pag.)CN106243151; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7681-82-5, name is Sodium iodide, A new synthetic method of this compound is introduced below., Application In Synthesis of Sodium iodide

General procedure: A typical example is exemplified by the synthesis of 4b: To a stirred solution of TMEDA (1.36 mL,9 mmol) in hexane (5 mL) was added dropwise at ice bath temperature n-butyllithium (9 mmol) in hexane followed by acetophenone trimethylsilyl enol ether 1 (576 mg, 3 mmol), and the mixture was stirred for 24 h at room temperature. In a separate flask, a mixture of bismuth(III) chloride (315.5 mg,1 mmol) and tris(4-methylphenyl)bismuthane (964 mg, 2 mmol) was stirred in ether (10 mL) at room temperature for 1 h. To the suspension of chlorobis(4-methylphenyl)bismuthane (ca. 3 mmol) thus formed was added sodium iodide (450 mg, 3 mmol) and a few drops of 15-crown-5 ether and the resulting yellowish mixture was stirred for 3 h at room temperature. To a suspension of the lithium compound previously prepared was added at room temperature magnesium dibromide diethyl etherate (775 mg, 3 mmol) followed by, at -30 C, a suspension of iodobis(4-methylphenyl)bismuthane(ca. 9 mmol), and the resulting mixture was stirred for 1 h, during which time the temperature was raised to ambient temperature. The reaction mixture was poured into brine (50 mL) and extracted with ethyl acetate (50 mL ¡Á 3). The combined extracts were concentrated to leave an oily residue, which was purified by chromatography (silica gel) using hexane-ethyl acetate (5:1) as the eluent to afford 4b in 30% yield (459 mg, 0.9 mmol). Because 4a, 4f and 10 underwent decomposition when purified by chromatography on silica gel, these compounds were converted into the corresponding halobismuthanes 5a, 5f and 11, respectively, without isolation.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Murafuji, Toshihiro; Tomura, Mai; Ishiguro, Katsuya; Miyakawa, Isamu; Molecules; vol. 19; 8; (2014); p. 11077 – 11095;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7681-82-5, Computed Properties of INa

To a dry round-bottom flask with a stir bar was added 5c (245 mg, 0.983 mmol) and NaI (460 mg, 3.06 mmol). Chlorotrimethylsilane (375 muL, 2.95 mmol) was added dropwise over 5 min at 0C, allowed to stir at 0C for 5 more min, and warmed to rt for 3 hr. The mixture was concentrated, dissolved in ether (25 mL) and 1M HCl (~10 mL), and transferred to a separatory funnel. The aqueous layer was extracted once more with ether (25 mL) and combined organics were washed once with with sat?d NaHSO3 and once with sat?d brine. The organic layer was dried over Na2SO4, filtered, concentrated, and dried in vacuo to afford a dry, white solid 7 (181 mg, 72%) which did not require further purification .1H NMR (CDCl3, 400 MHz) delta 4.52 (s, 2H), 5.06 (s, 2H), 7.29 (d, 1H, J=7.9), 7.51 (d, 1H, J=7.8), 7.75 (s, 1H).13C NMR (CDCl3, 100 MHz) delta 5.47, 71.21, 121.66, 130.50, 131.77, 138.51, 153.53. 11B NMR (CDCl3, 128 MHz) delta 32.24. HRMS (MAII) calc. for C8H8BO2 [M-I]+ 147.0612, found 147.0623.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Sodium iodide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF THE SCIENCES; TOMSHO, John, W.; GAMRAT, James, M.; (0 pag.)WO2019/173814; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7681-82-5, Recommanded Product: Sodium iodide

Complex [Pd(P,P)Cl2] (0.070?g, 0.113?mmol) was dissolved at room temperature in aceton (10?mL), followed by the addition of NaI in stoichiometric excess (0.070?g, 0.452?mmol), affording a dark yellow solution, which was stirred at room temperature for 24?h. The reaction mixture was then concentrated to dryness and the solid residue was re-dissolved in dichloromethane (10?mL). This solution was filtrated through celite in order to remove the remaining NaI or NaCl formed during the reaction. The filtrate was concentrated to 4?mL, n-hexane (10?mL) were then added to allow precipitation of the expected product, that was collected by filtration, and dried under vacuum to afford 0.060?g (67% yield) of a dark yellow powder, m.p. (dec.)?>?200?C. IR (KBr, cm-1): 506 (s), 528 (m), 562 (s), 591 (m), 692 (s), 748 (s), 867 (s) nu(P-N-P), 995 (m), 1101 (s), 1097 (s), 1176 (s), 1224 (s), 1245 (s), 1307 (w), 1375 (m), 1434 (s) nu(P-Ph), 1457 (s), 1480 (s). 1H NMR (600?MHz, CDCl3): delta 8.23 (m, 8H, Ar), 7.68-7.65 (m, 4H, Ar), 7.61-7.59 (m, 8H, Ar), 0.96 (s, 9H, tBu). 31P{1H} NMR (121.5?MHz, CDCl3): delta 25.09. HRMS (positive ESI-MS): calcd for C28H29INP2Pd [M?-?I]+ 673.9849, found 673.9877; calcd for C28H29I2NNaP2Pd [M+Na]+ 823.8792, found 823.8830.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium iodide, and friends who are interested can also refer to it.

Reference:
Article; Ioannou, Polydoros-Chrysovalantis; Arbez-Gindre, Cecile; Zoumpanioti, Maria; Raptopoulou, Catherine P.; Psycharis, Vassilis; Kostas, Ioannis D.; Kyritsis, Panayotis; Journal of Organometallic Chemistry; vol. 879; (2019); p. 40 – 46;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com