Category: 7681-82-5

Adding a certain compound to certain chemical reactions, such as: 7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7681-82-5, Formula: INa

To a dry round-bottom flask with a stir bar was added 5c (245 mg, 0.983 mmol) and NaI (460 mg, 3.06 mmol). Chlorotrimethylsilane (375 muL, 2.95 mmol) was added dropwise over 5 min at 0C, allowed to stir at 0C for 5 more min, and warmed to rt for 3 hr. The mixture was concentrated, dissolved in ether (25 mL) and 1M HCl (~10 mL), and transferred to a separatory funnel. The aqueous layer was extracted once more with ether (25 mL) and combined organics were washed once with with sat?d NaHSO3 and once with sat?d brine. The organic layer was dried over Na2SO4, filtered, concentrated, and dried in vacuo to afford a dry, white solid 7 (181 mg, 72%) which did not require further purification .1H NMR (CDCl3, 400 MHz) delta 4.52 (s, 2H), 5.06 (s, 2H), 7.29 (d, 1H, J=7.9), 7.51 (d, 1H, J=7.8), 7.75 (s, 1H).13C NMR (CDCl3, 100 MHz) delta 5.47, 71.21, 121.66, 130.50, 131.77, 138.51, 153.53. 11B NMR (CDCl3, 128 MHz) delta 32.24. HRMS (MAII) calc. for C8H8BO2 [M-I]+ 147.0612, found 147.0623.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Sodium iodide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF THE SCIENCES; TOMSHO, John, W.; GAMRAT, James, M.; (0 pag.)WO2019/173814; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Sodium iodide

Complex (-)-2 (0.29g, 0.32mmol) was dissolved in dichloromethane (50mL) and treated with excess concentrated hydrochloric acid (2mL) at room temperature for 5min. The mixture was then washed with water (3×50mL). Next, sodium iodide (0.1g) in water (50mL) was added and stirred vigorously for 3min. The organic layer was washed with water (3×50mL) and dried (MgSO4). The solvent was removed and the complex (-)-3 was isolated by column chromatography on a silica column with dichloromethane (0.19g, 70%). [alpha]D=-78.6 (c 0.14, CH2Cl2). Mp: 85-86C. Anal. Calcd for C26H26As2I2Pd: C, 36.8; H, 3.1. Found: C, 36.9; H, 3.2. 1H NMR (CDCl3, delta): 1.48 (s, 3H, =CCH3), 1.57 (s, 3H, =CCH3), 2.05 (dd, 3JHH=9.5, 2JHH=13.6Hz, 1H, CHCH2), 2.55 (d, 2JHH=13.0Hz, 1H, CHCH2), 2.96 (dt, 3JHH=2.1, 3JHH=9.4Hz, 1H, CHCH2), 3.07 (d, 3JHH=2.1Hz, 1H, AsCH), 3.52 (d, 3JHH=2.6Hz, 1H, AsCH), 7.37-8.02 (m, 15H, aromatics). 13C NMR (CDCl3, delta): 14.3, 15.7, 30.5, 31.4, 52.2, 56.3, 128.6, 129.1, 129.8, 129.9, 130.0, 130.9, 131.0, 131.1, 131.3, 131.6, 133.3, 133.7, 134.3, 135.8.

The synthetic route of 7681-82-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yao, Weiwei; Ma, Mengtao; Wang, Weifan; Cheng, Jianming; Xu, Li; Pullarkat, Sumod A.; Leung, Pak-Hing; Tetrahedron Asymmetry; vol. 25; 15; (2014); p. 1100 – 1103;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 7681-82-5,Some common heterocyclic compound, 7681-82-5, name is Sodium iodide, molecular formula is INa, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of complex [Pd(P,P)Cl2] (100 mg, 0.138 mmol) in10 mL of acetone, were added 207 mg of NuaI (1.380 mmol), underinert atmosphere and vigorous stirring. The dark yellow solutionwas stirred at room temperature for 2 h. After acetone wascompletely removed under vacuum, 10 mL of CH2Cl2 were addedto the resulting solid. The mixture was filtered in order to removethe inorganic salts. Subsequent addition of n-hexane (20 mL) to thefiltrate led to the formation of a yellow solid, which was filteredand dried under vacuum. Yield: 103 mg, 82%. HRMS (positiveESI-MS, Fig. S1, Supplementary Material): calcd for C30H35I2NNaO3P2PdSi [M+Na]+ 929.8878, found 929.8898; calcd forC30H35I2KNO3P2PdSi [M+K]+ 945.8617, found 945.8634. IR (KBr,cm1): 513 (s), 558 (m), 693 (s), 741 (s), 869 (s), 1098 (s), 1430(s), 2820 (w), 2931 (w). 1H NMR (300 MHz, CDCl3): d 0.20 (t, 2H,Si-CH2), 1.20 (m, 2H, -CH2-CH2-Si), 1.60, 2.80 (m, 2H, N-CH2),3.40 (s, 9H, Si-OCH3), 7.30, 7.4-8.0 (m, 20H, Harom). 31P NMR(121.5 MHz, CDCl3): d 24.2. UV-Vis (CH2Cl2), [k (nm), e (M1cm1)]: (418, 6800), (292, 23000), (263, 26150).

The synthetic route of 7681-82-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Stamatopoulos, Ioannis K.; Kapsi, Maria; Roulia, Maria; Vougioukalakis, Georgios C.; Raptopoulou, Catherine P.; Psycharis, Vassilis; Kostas, Ioannis D.; Kollar, Laszlo; Kyritsis, Panayotis; Polyhedron; vol. 151; (2018); p. 292 – 298;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 7681-82-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7681-82-5 as follows.

A mixture of the platinum vinylcarbene 8 (200mg, 0.261mmol) and NaI (391mg, 2.61mmol) in THF (15mL) was stirred for 5minat room temperature. All volatiles of the reaction mixture were removed under vacuum. The residue was extracted with DCM (5mL×2) and dried under reduced pressure to provide complex 14A as a yellow solid. Yield: 95% (235mg, 0.247mmol). 1H NMR (400MHz, CD2Cl2): delta 7.84 (d, J=1.8Hz, 1H, CH=CPh2) 7.63-7.68 (m, 6H), 7.38-7.49 (m, 19H), 5.04 (q, J=7.1Hz, 2H, CH2), 1.09 (t, J=7.1Hz, 3H, CH3). 31P{1H} NMR (162MHz, CD2Cl2): delta 8.6 (s, JPtP=2118.8Hz). 13C{1H} NMR (100MHz, CD2Cl2): delta 269.9 (d, J=141.3Hz, Pt=C), 154.9 (d, J=2.5Hz, HC=CPh2), 139.6 (ipso-CPh2), 138.3 (ipso-CPh2), 134.6 (d, J=10.8Hz, o- or m-PPh3), 133.5 (d, J=8.0Hz, HC=CPh2), 130.9 (d, J=50.0Hz, ipso-PPh3), 130.3, 129.6 (d, J=1.9Hz, p-PPh3), 129.2, 129.0, 128.0, 127.8, 127.2, 127.0 (d, J=9.8Hz, o- or m-PPh3), 79.2 (d, J=3.5Hz, CH2), 12.1 (CH3). Anal. Calcd. for C35H31I2OPPt: C, 44.37, H, 3.30. Found: C, 44.44, H, 3.49.

According to the analysis of related databases, 7681-82-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ruan, Wenqing; Shi, Chuan; Sung, Herman H.Y.; Williams, Ian D.; Jia, Guochen; Journal of Organometallic Chemistry; vol. 880; (2019); p. 7 – 14;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 7681-82-5, These common heterocyclic compound, 7681-82-5, name is Sodium iodide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A typical example is exemplified by the synthesis of 4b: To a stirred solution of TMEDA (1.36 mL,9 mmol) in hexane (5 mL) was added dropwise at ice bath temperature n-butyllithium (9 mmol) in hexane followed by acetophenone trimethylsilyl enol ether 1 (576 mg, 3 mmol), and the mixture was stirred for 24 h at room temperature. In a separate flask, a mixture of bismuth(III) chloride (315.5 mg,1 mmol) and tris(4-methylphenyl)bismuthane (964 mg, 2 mmol) was stirred in ether (10 mL) at room temperature for 1 h. To the suspension of chlorobis(4-methylphenyl)bismuthane (ca. 3 mmol) thus formed was added sodium iodide (450 mg, 3 mmol) and a few drops of 15-crown-5 ether and the resulting yellowish mixture was stirred for 3 h at room temperature. To a suspension of the lithium compound previously prepared was added at room temperature magnesium dibromide diethyl etherate (775 mg, 3 mmol) followed by, at -30 C, a suspension of iodobis(4-methylphenyl)bismuthane(ca. 9 mmol), and the resulting mixture was stirred for 1 h, during which time the temperature was raised to ambient temperature. The reaction mixture was poured into brine (50 mL) and extracted with ethyl acetate (50 mL × 3). The combined extracts were concentrated to leave an oily residue, which was purified by chromatography (silica gel) using hexane-ethyl acetate (5:1) as the eluent to afford 4b in 30% yield (459 mg, 0.9 mmol). Because 4a, 4f and 10 underwent decomposition when purified by chromatography on silica gel, these compounds were converted into the corresponding halobismuthanes 5a, 5f and 11, respectively, without isolation.

Statistics shows that Sodium iodide is playing an increasingly important role. we look forward to future research findings about 7681-82-5.

Reference:
Article; Murafuji, Toshihiro; Tomura, Mai; Ishiguro, Katsuya; Miyakawa, Isamu; Molecules; vol. 19; 8; (2014); p. 11077 – 11095;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7681-82-5, name is Sodium iodide, A new synthetic method of this compound is introduced below., Recommanded Product: 7681-82-5

General procedure: 74.4mg (0.133mmol) of 1a? and 201mg (1.34mmol) of NaI are added to a round bottom flask with a stir bar followed by 10ml of THF. A reflux condenser is attached and the flask is submerged in an oil bath and refluxed for 3h. Then the mixture is allowed to cool to room temperature and solvent is evaporated. The residue is extracted with CH2Cl2, sonicated, and filtered through Celite with CH2Cl2. The process was repeated 3 times to remove and sodium halide. The solvent is evaporated from the combined extracts

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Walsh, Aaron P.; Brennessel, William W.; Jones, William D.; Inorganica Chimica Acta; vol. 407; (2013); p. 131 – 138;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 7681-82-5, These common heterocyclic compound, 7681-82-5, name is Sodium iodide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 44.81 g of lithium chloride in acetone was added 151.19 g of sodium iodide(1.05: 1). After 1 hour reaction, the reaction was completed and the sodium chloride was filtered off. The filtrate was concentrated to dryness to obtain lithium iodide. After drying, 134.12 g (97.80%) of anhydrous lithium iodide Rate 98%. Steamed acetone recovery, in addition to water recycling. The conversion ratio of anhydrous lithium chloride and anhydrous sodium iodide was 1.05: 1, and the conversion rate of lithium iodide was higher than that of Example 1.

Statistics shows that Sodium iodide is playing an increasingly important role. we look forward to future research findings about 7681-82-5.

Reference:
Patent; Shandong Boyuan Pharmaceutical And Chemical Co., Ltd.; Li Chenglin; Wang Qingmin; Zhai Yongli; Chu Rongqiang; (8 pag.)CN106928268; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

7681-82-5, name is Sodium iodide, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: INa

Complex (-)-2 (0.29g, 0.32mmol) was dissolved in dichloromethane (50mL) and treated with excess concentrated hydrochloric acid (2mL) at room temperature for 5min. The mixture was then washed with water (3×50mL). Next, sodium iodide (0.1g) in water (50mL) was added and stirred vigorously for 3min. The organic layer was washed with water (3×50mL) and dried (MgSO4). The solvent was removed and the complex (-)-3 was isolated by column chromatography on a silica column with dichloromethane (0.19g, 70%). [alpha]D=-78.6 (c 0.14, CH2Cl2). Mp: 85-86C. Anal. Calcd for C26H26As2I2Pd: C, 36.8; H, 3.1. Found: C, 36.9; H, 3.2. 1H NMR (CDCl3, delta): 1.48 (s, 3H, =CCH3), 1.57 (s, 3H, =CCH3), 2.05 (dd, 3JHH=9.5, 2JHH=13.6Hz, 1H, CHCH2), 2.55 (d, 2JHH=13.0Hz, 1H, CHCH2), 2.96 (dt, 3JHH=2.1, 3JHH=9.4Hz, 1H, CHCH2), 3.07 (d, 3JHH=2.1Hz, 1H, AsCH), 3.52 (d, 3JHH=2.6Hz, 1H, AsCH), 7.37-8.02 (m, 15H, aromatics). 13C NMR (CDCl3, delta): 14.3, 15.7, 30.5, 31.4, 52.2, 56.3, 128.6, 129.1, 129.8, 129.9, 130.0, 130.9, 131.0, 131.1, 131.3, 131.6, 133.3, 133.7, 134.3, 135.8.

The synthetic route of 7681-82-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yao, Weiwei; Ma, Mengtao; Wang, Weifan; Cheng, Jianming; Xu, Li; Pullarkat, Sumod A.; Leung, Pak-Hing; Tetrahedron Asymmetry; vol. 25; 15; (2014); p. 1100 – 1103;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 7681-82-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7681-82-5 name is Sodium iodide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: We used a simple method (branched tube glass) in order to design and preparation of suitable single crystals for X-ray diffraction. The one-pot reaction of a 1:1 M ratio of Cd(II) salts and L in the mixture of EtOH and MeOH afforded the compounds 1-3 in good yields. Cd(NO3)2·4H2O (0.154g, 0.5mmol), NaHal (Hal=Cl, 0.058g; Br, 0.103g; I, 0.150g; 1mmol) and the ligand L (0.208g, 0.5mmol) were placed in the main arm of a branched tube. A mixture of MeOH (7.5mL) and EtOH (7.5mL) was carefully added to fill the arms. The tube was sealed and immersed in an oil bath at 60C while the branched arm was kept at ambient temperature. X-ray suitable crystals were formed during the next days in the cooler arm and were filtered off, washed with acetone and diethyl ether, and dried in air.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium iodide, and friends who are interested can also refer to it.

Reference:
Article; Akbari Afkhami, Farhad; Mahmoudi, Ghodrat; White, Jonathan M.; Lipkowski, Janusz; Konyaeva, Irina A.; Safin, Damir A.; Inorganica Chimica Acta; vol. 484; (2019); p. 481 – 490;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 7681-82-5, These common heterocyclic compound, 7681-82-5, name is Sodium iodide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of [3]- (50 mg, 0.081 mmol) in acetonitrile (2 mL), chloramine-T (37 mg, 0.129 mmol),sodium iodide (15 mg, 0.097 mmol) and acetic acid (130 L) were added. The reaction mixture wasallowed to stir at room temperature for 10 h. For the workup, 20 mL of water were added and extractedwith ethyl acetate (3 x 15 mL), the organic layers were combined and washed with brine solution beforedrying over anhydrous sodium sulphate. The solvent was evaporated and the crude was purifiedusing column chromatography (silica gel, 10% MeOH in dichloromethane) to yield [5]- as a yellowsolid (25 mg, 41.6%). 1H-NMR (methanol-d4) delta 4.27 [Cc-H, 2H, s], 4.13 [Cc-H, 2H, s], 3.37 [CH2O, 2 H,t], 2.85 [CH2-S, 2 H, t], 2.31 [CH3, 3 H, s], 1.55 [CH2-CH2-O, 2 H, m], 1.45 [CH2-CH2S, 2 H, m], 1.36[CH2-CH2CH2O, 2 H, m]; 11B-NMR (methanol-d4) delta 21.47 [1B, s], 0.42[2B, d, 1J(B-H) = 145.4], 4.39[1B, s], 5.71 [4B, d, 1J(B-H) = 140.0], 7.27 [4B, d, 1J(B-H) = 152.8], 18.07 [2B, d, 1J(B-H) = 152.4],20.04 [2B, d, 1J(B-H) = 161.3], 23.45 [1B, d, 1J(B-H) = 161.3], 27.37 [1B, d, 1J(B-H) = 170.4]; 13C-NMR(CDCl3) delta 191.05, 70.24, 58.99, 56.52, 34.78, 33.10, 32.97, 32.52, 29.24. LCMS (ESI) Experimental [M]- m/z = 606.6 (theoretical [M]- m/z = 607.6).

Statistics shows that Sodium iodide is playing an increasingly important role. we look forward to future research findings about 7681-82-5.

Reference:
Article; Pulagam, Krishna R.; Gona, Kiran B.; Gomez-Vallejo, Vanessa; Meijer, Jan; Zilberfain, Carolin; Estrela-Lopis, Irina; Baz, Zurine; Cossio, Unai; Llop, Jordi; Molecules; vol. 24; 19; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com