Category: 76801-93-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, A new synthetic method of this compound is introduced below., Computed Properties of C14H18I3N3O6

In a three-necked flask equipped with a stirrer and a reflux condenser,5-amino-N, N’-bis- (2,3-dihydroxypropyl) -2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol)N, N-dimethylacetamide (172 ml)Stir,Heated to 50 C dissolved, cooled to 10 C,A solution of chloroacetyl chloride (62 ml, 88.09 g, 0.78 mol)About 30min drop finished,The temperature was raised to 50 C for 3 h,Cooling to 0 ~ 10 ,At 10 ,Dropping 10 ml / L of sodium hydroxide solution 156 ml,Stir at room temperature for 1 h.After adding 100 ml of water, 59 ml of 1N hydrochloric acid was added dropwise, and the mixture was allowed to stand overnight. The filtrate was washed with water and dried to give 83.2 g of a yield of 90.0%.

The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiang Su Heng Rui Medicine Co., Ltd.; Hou, Xianshan; Wang, Junyan; Wang, Zhian; Zhong, Xinguang; (9 pag.)CN106278929; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 76801-93-9, These common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

compound of formula [2] 5-amino-2,4,6-triiodo-N,N’-bis(2,3-dihydroxypropyl)-1,3-phthalamideReacts with acetic anhydride,The temperature is raised to 65 C -70 C for 2-6 hours, and the TLC monitoring reaction is completed.Concentrated under reduced pressure to obtain a compound of the formula [3]5-acetamido-2,4,6-triiodo-N,N’-bis(2,3-diacetoxypropyl)-1,3-phthalic acid amide;

Statistics shows that 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide is playing an increasingly important role. we look forward to future research findings about 76801-93-9.

Reference:
Patent; Tianjin Heqing Chemical Co., Ltd.; Liu Guoping; Li Yi; (7 pag.)CN108191690; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 76801-93-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(b) (+)-5-Acetamido-2,4,6-triiodo-N,N’-bis(2,3-dihydroxypropyl)-isophthalamide The dextrorotatory compound was prepared from (+)-5-amino-2,4,6-triiodo-N,N’-bis(2,3-dihydroxypropyl)-isophthalamide (21 g) by acetylation and a subsequent hydrolysis at pH 10-11 in a similar manner to that described in C(a) above. Finally the product was recrystallized from water. Yield: 13.6 g (61%) [alpha]546 =+4.0; [alpha]578 =+3.8 (c=4.5; DMF:H2 O=2:8). Melting Point: 285-289 dec. Analysis–Found: C, 25.80; H, 2.50; I, 50.6; N, 5.71. Calc. for C16 H20 I3 N3 O7: C, 25.72; H, 2.70; I, 50.95; N, 5.62.

The synthetic route of 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nyegaard & Co. A/S; US4250113; (1981); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 76801-93-9, SDS of cas: 76801-93-9

In a three-necked flask equipped with a stirrer and a reflux condenser, a solution of 5-amino-N, N-bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol) N,N’-dimethyl acetamide 172ml, stirring, heating to 50 C dissolved, cooled to 10 C, add chloroacetyl chloride 62ml (88.09g, 0.78mol) dropwise for about 30 minutes, heated to 50 C stirring for 3h, cooling to 0 ~ 10 C, at 10 C, dropping 10mol / L sodium hydroxide solution 156ml, room temperature stirring 1h. After adding 100 ml of water, 59 ml of 1N hydrochloric acid was added dropwise, and the mixture was allowed to stand overnight. The filtrate was washed with water and dried to give 83.2 g of a yield of 90.0%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Hengrui Medicine Co., Ltd.; Hou, Xianshan; Wang, Junyan; (11 pag.)CN106336362; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

Formic acid (300 ml) was charged in a dry 1000 ml flask fitted with a dropping funnel, stir bar, thermometer and a gas inlet. The acid was cooled on an ice bath under a nitrogen blanket and acetic anhydride (144.8 g, 1.418 mol) was added drop wise at a rate so that the temperature did not exceed 2.5 C. After complete addition, the ice bath was removed and the temperature was allowed to reach 10 C. The mixture was again ice cooled and 5-amino-N,N’-bis(2,3-dihydroxypropyl)-2,4,6- triiodo-isophthalamide (100 g, 141.8 mmol) was added over 5 minutes and the mixture was left stirring over night while attaining ambient temperature. The mixture was evaporated to dryness and methanol (300 ml) and water (300 ml) was added. 2 M potassium hydroxide was added until all material was in solution and a stable pH 12.5 was attained. The methanol was removed in vacuo. The mixture was neutralized with 4 M HCI and a slow precipitation started. 300 ml water was added and the product was precipitated over night.The precipitate was collected and rinsed with a small amount of water and dried on filter to a moist cake and further dried in vacuo to yield 84.8 g ( 81.5 %) of N,N’-bis-(2,3-dihydroxy-propyl)-5-formylamino-2,4,6-triiodo-isophthalamide.

The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GE Healthcare Ekushey Sales Cap; Thaning, Mikkel; (47 pag.)JP5830589; (2015); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 76801-93-9

Compound B was acetylated by a mixture of acetic anhydride and acetic acid (concentration about 91 v/v %, 2.0 L/kg Compound B) at 50-125C in the presence of catalytic amounts of p-toluene sulphonic acid. Excess acetic anhydride and acetic acid were distilled off under reduced pressure, and the resulting viscous solution diluted with methanol and water and hydrolysed by addition of aqueous sodium hydroxide at 50-60C to a stable pH of about 12. Hydrochloric acid (17.5 w/w %) was added to a pH of about 10.5-11.5 at 60C. Then, seeds of crystalline Compound A (0.004 kg/kg Compound B) were added, and pH was further adjusted to 6.5-7.5 by hydrochloric acid (17.5 w/w %). At this stage the solvent composition was approximately 25 % methanol and 75 % water, with a total mother liquor volume of about 3.8 L/kg Compound A. In reactor A of each experiment a certain fraction of the mother liquor volume was removed by distillation, either at atmospheric or reduced pressure (95-100C at atmospheric pressure, 55-60C under reduced pressure). In reactor B nothing was distilled off. The content of both reactors were then allowed to cool gradually to 15C over 10-12 hours before filtration, wash with methanol and drying under reduced pressure and elevated temperature. The purity of the crystals was measured by HPLC. The following results were obtained:

The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GE Healthcare AS; EP2281791; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

In a three-necked flask equipped with a stirrer and a reflux condenser,5-amino-N, N’-bis- (2,3-dihydroxypropyl) -2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol)N, N-dimethylacetamide (172 ml)Stir,Heated to 50 C dissolved, cooled to 10 C,A solution of chloroacetyl chloride (62 ml, 88.09 g, 0.78 mol)About 30min drop finished,The temperature was raised to 50 C for 3 h,Cooling to 0 ~ 10 ,At 10 ,Dropping 10 ml / L of sodium hydroxide solution 156 ml,Stir at room temperature for 1 h.After adding 100 ml of water, 59 ml of 1N hydrochloric acid was added dropwise, and the mixture was allowed to stand overnight. The filtrate was washed with water and dried to give 83.2 g of a yield of 90.0%.

The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiang Su Heng Rui Medicine Co., Ltd.; Hou, Xianshan; Wang, Junyan; Wang, Zhian; Zhong, Xinguang; (9 pag.)CN106278929; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 76801-93-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1Ten experiments were made, each of which used two parallel crystallisers (reactors A and B) where one had mother liquor distilled off and one had not. The solutions of crude Compound A were in all cases made the following way.Compound B was acetylated by a mixture of acetic anhydride and acetic acid (concentration about 91 v/v %, 2.0 L/kg Compound B) at 50-125 C. in the presence of catalytic amounts of p-toluene sulphonic acid. Excess acetic anhydride and acetic acid were distilled off under reduced pressure, and the resulting viscous solution diluted with methanol and water and hydrolysed by addition of aqueous sodium hydroxide at 50-60 C. to a stable pH of about 12. Hydrochloric acid (17.5 w/w %) was added to a pH of about 10.5-11.5 at 60 C. Then, seeds of crystalline Compound A (0.004 kg/kg Compound B) were added, and pH was further adjusted to 6.5-7.5 by hydrochloric acid (17.5 w/w %). At this stage the solvent composition was approximately 25% methanol and 75% water, with a total mother liquor volume of about 3.8 L/kg Compound A.In reactor A of each experiment a certain fraction of the mother liquor volume was removed by distillation, either at atmospheric or reduced pressure (95-100 C. at atmospheric pressure, 55-60 C. under reduced pressure). In reactor B nothing was distilled off. The content of both reactors were then allowed to cool gradually to 15 C. over 10-12 hours before filtration, wash with methanol and drying under reduced pressure and elevated temperature. The purity of the crystals was measured by HPLC. The following results were obtained: Water Reduction Water Reduction Isolated content in of mother content in of mother yield mother Compound liquor mother Compound liquor increase, liquor, B purity, volume, liquor, B purity, volume, reactor B vs. reactor A reactor A reactor A reactor B reactor B reactor B reactor A 1 81% 99.6% 11% 76% 99.6% None 1.3% 2 84% 99.6% 11% 76% 99.6% None 1.4% 3 85% 99.5% 14% 78% 99.5% None 1.7% 4 84% 99.5% 17% 73% 99.6% None 1.9% 5 83% 99.5% 14% 75% 99.5% None 1.6% 6 88% 99.5% 27% 77% 99.4% None 2.9% 7 91% 99.5% 24% 80% 99.5% None 2.5% 8 89% 99.5% 36% 76% 99.5% None 2.9% 9 85% 99.4% 28% 74% 99.5% None 2.4% 10 89% 99.4% 32% 75% 99.5% None 3.1%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GE HealthCare AS; US7754920; (2010); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 76801-93-9, These common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

According to the compound of formula 1 and 3-chloro-1,2-propanediol,The molar ratio of sodium methoxide is 1:1:1.50 g of Compound Formula 1, 60 mL of methanol and 4.54 g of sodium methoxide were added to the reaction flask.3-chloro-1,2-propanediol 9.24g,Heat to 20-60 C for 10-20 hours.Distill off methanol and add 50 mL of water.Adjust the pH to 5-7 with hydrochloric acid,Add 80 mL of isopropanol and cool to 0-10 C.Precipitating crystals,dry,5-(2,3-Dihydroxypropyl)amino-N,N’-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-phthalamide solid (compound of formula 8),The purity is 95.6%.

The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Brethren Technology Co., Ltd.; Zhan Guowu; Xiong Anwei; Zhou Zhongping; Qian Zhida; (9 pag.)CN109912445; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C14H18I3N3O6

In a three-necked flask equipped with a stirrer and a reflux condenser,5-amino-N, N’-bis- (2,3-dihydroxypropyl) -2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol)N, N-dimethylacetamide 172ml, stirred, heated to 50 C dissolved, cooled to 10 C, chloroacetyl chloride 62ml (88.09g, 0.78mol) dropwise over about 30min was completed, heated to 50 C and stirred for 3h, Cooled to 0 ~ 10 , at 10 ,156ml of 10mol / L sodium hydroxide solution was added dropwise and stirred at room temperature for 1h.100 ml of water was added and 59 ml of 1N hydrochloric acid was added dropwise. After standing overnight, the mixture was filtered and the filter cake was washed with water and dried to give 83.2 g. The yield was 90.0%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 76801-93-9, its application will become more common.