Category: 766-99-4

Adding a certain compound to certain chemical reactions, such as: 766-99-4, name is 1-Ethynyl-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766-99-4, Product Details of 766-99-4

4-iodophenylacetylene 114 mg (0.5 mmol), silver nitrite 115.5 mg (0.75 mmol), N-chlorosuccinimide133.5 mg (1.0 mmol) was sequentially added to a 10 mL pressure-resistant sealed container, and 5 mL of acetonitrile was further added.The mixture was stirred at room temperature, and the reaction was checked by TLC, and the reaction was completed in 6 hours.The reaction solution was diluted with 10 mL of dichloromethane, and filtered to give a clear liquid.Separation by column chromatography (extraction of petroleum ether/ethyl acetate in a volume ratio of 50:1)The eluate containing the desired product were collected and the solvent was evaporated to give 4-iodo-benzonitrile as a white solid 52.7mg (46% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Zhejiang University of Technology; Liu Yunkui; Zhang Jian; Bao Hanyang; (9 pag.)CN107641088; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 766-99-4, The chemical industry reduces the impact on the environment during synthesis 766-99-4, name is 1-Ethynyl-4-iodobenzene, I believe this compound will play a more active role in future production and life.

To a suspended solution of ZnBr2 (1.10 mmol, 0.176 g) and (4-iodophenyl)ethyne (15.3 mmol, 3.50 g) in THF (40 mL) was added tributyl(methoxy)stannane (18.4 mmol, 5.91 g). The mixture was stirred for 3 h at room temperature, and then quenched by NH4F(aq) (10%, 50 mL). The obtained white precipitate was filtered off, and the filtrate was extracted with Et2O (3 x 10 mL) and dried over MgSO4. The volatiles were removed under reduced pressure to give a pure product (100% purity (A small portion was analyzed by 1H NMR using 1,1,2,2-tetrachloroethane as an internal standard to determine the purity)).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethynyl-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Suzuki, Itaru; Esumi, Naoto; Yasuda, Makoto; Baba, Akio; Chemistry Letters; vol. 44; 1; (2015); p. 38 – 40;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-99-4, name is 1-Ethynyl-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: iodides-buliding-blocks

General procedure: An oven-dried Schlenk reaction tube equipped with a magnetic stirrer bar and a Teflon stopcock was evacuated while hot and allowed to cool under N2. The tube was first charged with CuI (0.02 mmol), TMEDA (0.05 mmol), and benzoyl chloride (1.2 mmol), follow byphenylacetylene (1 mmol) and Et3N (3.0 mmol). The mixture wasthen stirred at r.t. for 1 h under N2. When the reaction was complete, sat. aq NaHCO 3 (5 mL) and EtOAc (20 mL) were added. The reaction system was allowed to partition, and the organic phase was dried with Na2SO4, filtered, and concentrated on a rotary evaporator. The residue was purified by chromatography (silica gel) to give the cross-coupling product 3a (185.4 mg, 90%) as a white solid.

The synthetic route of 766-99-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yin, Weiyan; He, Haifeng; Zhang, Yani; Luo, Di; He, Hongwu; Synthesis; vol. 46; 19; (2014); p. 2617 – 2621;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 766-99-4 as follows. HPLC of Formula: C8H5I

To a solution of l-ethynyl-4-iodobenzene 6 (0.908 g, 3.98 mmol) in THF (20 mL) at -78 0C was added ethylmagnesium bromide (3M in ether, 1.39 mL, 4.18 mmol). After 10 minutes the cooling bath was removed and the solution was allowed to stir at room temperature for 1 hour. The reaction mixture was then re- cooled to 0 0C and added to a solution of N-(tert-butoxycarbonyl)-L-proline N’- methoxy-N’-methylamide 2 (0.970 g, 3.76 mmol) in THF (10 mL). The reaction mixture was warmed to room temperature and stirring was continued for 12 hours before the mixture was quenched with saturated NH4Cl. The mixture was diluted with ethyl acetate/H2O, the layers separated and the aqueous phase was re-extracted with ethyl acetate (2x). The combined organic layers were washed (H2O, brine), dried (Na2SO4), and filtered, and the solvent was removed in vacuo. The resulting residue was purified by flash chromatography (hexane: ethyl acetate, 4: 1) to give (S)- tert-butyl 2-(3-(4-iodophenyl)propioloyl)pyrrolidine-l-carboxylate 7 (0.908 g, 71%) as a yellow oil which solidified on standing. 1H NMR (400 MHz, CDCl3) delta 7.72 – 7.76 (m, 2H), 7.26 -7.30 (m, 2H), 4.49 (dd, J=S. S, 4.3 Hz, 0.3H), 4.29 (dd, J=8.5, 5.5 Hz, 0.7 H), 3.59 (app t, J=6.7 Hz, 2H), 2.20 – 2.33 (m, IH), 1.85 – 2.10 (m, 3H), 1.45, 1.40 (s, 9H, rotamers in 2:3 ratio). LCMS: Anal. Calcd. for Ci8H20INO3: 425; found: 326 (M+H-Boc)+.

According to the analysis of related databases, 766-99-4, the application of this compound in the production field has become more and more popular.

Reference of 766-99-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-99-4, name is 1-Ethynyl-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A 25 mL reaction flask was charged with ferrous chloride (0.05 mmol),4-iodophenylacetylene (0.5 mmol), 4-fluorobenzeneboronic acid (0.75 mmol),Sodium carbonate (1.0 mmol),Cesium hydroxide monohydrate (2.5 mmol),Sodium iodide (0.25 mmol),(0.75 mmol), & lt; / RTI & gt;Chloroform (1.5 mmol) and polyethylene glycol-400 (2.0 g),And reacted at 120 C for 6 h. Cooled to room temperature,extraction,The solvent was distilled off under reduced pressure, and the residue was isolated by column chromatography to give a yield of 87%.

The synthetic route of 1-Ethynyl-4-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Normal University; HAN, WEI; DU, HONGYAN; (14 pag.)CN106116999; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-99-4, name is 1-Ethynyl-4-iodobenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Ethynyl-4-iodobenzene

General procedure: (3-Methoxypent-1-yne-1,5-diyl)dibenzene (10a) A 10 mL test tube equipped with a magnetic stirring bar was charged with IPrAu(BTZ-H) OTf (1.7 mg, 1.99 mumol, 2 mol%) and THF (200 muL, 0.5 M). To the solution were added acetal 8a (18.0 mg, 0.100 mmol) and alkyne 2a (55.0 muL, 0.500 mmol, 5.0 eq) at room temperature. The mixture was heated at 100C and the solution was stirred until TLC (hexanes-Et2O = 10 : 1) indicated a complete consumption of acetal 8a. The reaction was quenched with saturated aqueous NaHCO3 and the mixture was extracted with AcOEt three times. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel (hexanes-Et2O = 60 : 1) to afford propargyl ether 10a (21.9 mg, 87.5 mumol, 87%).

The synthetic route of 766-99-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Furuta, Miyu; Sugiyama, Kyoko; Yamaguchi, Minami; Ueda, Hirofumi; Tokuyama, Hidetoshi; Chemical and Pharmaceutical Bulletin; vol. 67; 8; (2019); p. 872 – 876;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 766-99-4, name is 1-Ethynyl-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 766-99-4

General procedure: A mixture of alkyne 1 (0.25 mmol), sodium sulfinate 2 (0.375 mmol), FeCl3 (20 mol %),K2S2O8 (20 mol %), and water (3 mL) was stirred at rt in an open flask for 6-9 h(Table 2). After completion of the reaction (monitored by TLC), the mixture was extracted with EtOAc (3 5 mL). The combined organic phases were dried over anhyd. Na2SO4, filtered, and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography using a mixture of EtOAc-n-hexane (1:4) as eluent to afford an analytically pure sample of beta-keto sulfones 3 (Table 2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 766-99-4.

Reference:
Article; Singh, Atul K.; Chawla, Ruchi; Yadav, Lal Dhar S.; Tetrahedron Letters; vol. 55; 17; (2014); p. 2845 – 2848;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

766-99-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 766-99-4 as follows.

A solution of 4-iodophenyleneacetylene in 0.5 mmol (113 mg)N-chlorosuccinimide 1 mmol (133 mg),Silver nitrate 1 mmol (154 mg) and tetrahydrofuran 5 ml were successively added to a 25 ml volume sealed pressure vessel.The mixture was reacted at 50 C for 8 hours.After completion of the TLC reaction, the reaction solution was diluted with methylene chloride and filtered to give a clear solution which was separated by column chromatography (eluent ratio: petroleum ether to ethyl acetate volume ratio of 10: 1) The eluate was removed by evaporation of the eluent to give 1-iodo-4- (nitroalkynyl) benzene (58% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 766-99-4, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University of Technology; Liu, Yunkui; Zhang, Wei; Zhang, Jian; (10 pag.)CN106478327; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com