Category: 75581-11-2

Adding a certain compound to certain chemical reactions, such as: 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75581-11-2, COA of Formula: C8H9IO

To a stirring solution of aryl iodide S12 (5.0 g, 20 mmol, 1 .0 equiv), PdCI2(PPh3)2 (0.28 g, 0.40 mmol, 2 mol%), and Cul (0.15 g, 0.79 mmol, 4 mol%) in 50 ml_ triethylamine under N2 atmosphere at rt was added TMS-acetylene (2.4 g, 24 mmol, 1 .2 equiv) dropwise. The resulting yellow suspension was stirred overnight (approx. 17 h) under N2 atmosphere at rt. The reaction mixture was filtered through a pad of celite, and the filtrate was concentrated in vacuo. The crude oil was dissolved in hexanes, and then passed through a pad of silica using 95% hexanes: 5% ethylacetate as the eluent. The resulting solution was dried over anhydrous Na2S04, filtered through a coarse fritted glass funnel, and the filtrate was concentrated in vacuo to afford 4.1 g of compound alkyne 28 as a yellow solid (93%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methoxy-2-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TRUSTEES OF DARTMOUTH COLLEGE; MICALIZIO, Glenn C.; EASTMAN, Alan; (149 pag.)WO2019/35061; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 75581-11-2, A common heterocyclic compound, 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, molecular formula is C8H9IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a typical reaction, styrene (1.0 mmol) and aryl halide (1.5 mmol) were reacted in a homogeneous mixture of toluene and PEG-600 (20 ml, 3:1) in the presence of 3 mol % of Cl2PdPEGD catalyst(34.4 mg) and Cs2CO3 (1.5 mmol), under a nitrogen atmosphere at 80 C for 5 h until complete consumption of aryl halide. The reaction progress was monitored by TLC and GC analysis. The mixture was cooled to room temperature and 20 ml of n-hexane was added to separate lower catalyst-philic PEG phase from upper product phase. The product was isolated by decantation and evaporation of solvents under vacuum. Catalyst-philic PEG phase containing polyether palladium catalyst was subjected to reuse by charging with the same amount of the substrates styrene (1.0 mmol) and aryl halide (1.5 mmol), Cs2CO3 (2.0 mmol) and toluene. The identity and purity of the products were confirmed by GC and GC-MS.

The synthetic route of 75581-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sawant, Dinesh; Wagh, Yogesh; Bhatte, Kushal; Panda, Anil; Bhanage, Bhalchandra; Tetrahedron Letters; vol. 52; 18; (2011); p. 2390 – 2393;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 75581-11-2, The chemical industry reduces the impact on the environment during synthesis 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, I believe this compound will play a more active role in future production and life.

Step 1 : Preparation of ethyl 2,2-difluoro-2-(4-methoxy-3-methylphenyl)acetateTo a solution 4-iodo-1 -methoxy-2-methylbenzene (commercially available, 1 equiv) and ethyl 2-bromo-2,2-difluoroacetate (2 equiv) in DMF (0.3M) was added Cu powder (3 equiv). The reaction slurry was heated to 80C for 1 .5 days, quenched with saturated NaH2P04 (aq) and extracted with ethyl acetate. The organics were dried over Na2S04 and concentrated under vacuum. The residual was purified via silica gel column chromatography to afford the title product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methoxy-2-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; CORTEZ, Alex; HOFFMAN, Timothy; LI, Yongkai; WU, Tom Yao-Hsiang; ZHANG, Xiaoyue; WO2015/168279; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 75581-11-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[00359] In a reaction tube under nitrogen, a mixture of PdCl2(dppf)CH2Cl2 (21 mg; 0.026 mmol) and triethylamine (0.34 ml; 2.44 mmol) in dioxane (2.5 ml; dried over 4 A sieves) was sealed and stirred at 80 C. overnight (18 h). After cooling to room temperature, HB(pin) (0.19 ml; 1.31 mmol) was added followed by 1-iodo-4-methoxy-3-methylbenzene (215 mg; 0.867 mmol) in dioxane (2.5 ml; dried over 4 A sieves) and the reaction mixture was stirred at 80 C. GC analysis after 18 hours showed a single new peak at 11.4 minutes which was identified by GC/MS as the desired arylborate compound.

The synthetic route of 4-Iodo-1-methoxy-2-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75581-11-2, category: iodides-buliding-blocks

To a stirring solution of aryl iodide S12 (5.0 g, 20 mmol, 1 .0 equiv), PdCI2(PPh3)2 (0.28 g, 0.40 mmol, 2 mol%), and Cul (0.15 g, 0.79 mmol, 4 mol%) in 50 ml_ triethylamine under N2 atmosphere at rt was added TMS-acetylene (2.4 g, 24 mmol, 1 .2 equiv) dropwise. The resulting yellow suspension was stirred overnight (approx. 17 h) under N2 atmosphere at rt. The reaction mixture was filtered through a pad of celite, and the filtrate was concentrated in vacuo. The crude oil was dissolved in hexanes, and then passed through a pad of silica using 95% hexanes: 5% ethylacetate as the eluent. The resulting solution was dried over anhydrous Na2S04, filtered through a coarse fritted glass funnel, and the filtrate was concentrated in vacuo to afford 4.1 g of compound alkyne 28 as a yellow solid (93%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methoxy-2-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TRUSTEES OF DARTMOUTH COLLEGE; MICALIZIO, Glenn C.; EASTMAN, Alan; (149 pag.)WO2019/35061; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75581-11-2 as follows. Product Details of 75581-11-2

Tri(o-tolyl)phosphine (30 mg, 0.1 mmol) and palladium (II) acetate (11.0 mg, 0.05 mmol) were dissolved in hexamethylphosphoramide (0.1 mL). The mixture was stirred for 5 min, then water (0.9 mL), potassium carbonate (0.42 g, 3 mmol), acrylic acid (1.14 mL, 2 mmol) and 4-iodo-1-methoxy-2-methylbenzene S1 (0.25 g, 1 mmol) obtained above were added. The mixture was stirred at 90 C for 5 h, filtered and the solution was acidified with conc. H2SO4 (to pH 1). The milky suspension was extracted with ethyl acetate (30 mL), the organic layer was dried with anhydrous sodium sulfate and the solvent evaporated. The resulting solid was recrystallized from isopropanol to give 12b as a pale yellow solid (0.115g, 60 %); mp 200-201 C, (lit. 201 C) identical (1H NMR) to that described.

According to the analysis of related databases, 75581-11-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Martinez, Mario David; Riva, Diego Ariel; Garcia, Cybele; Duran, Fernando Javier; Burton, Gerardo; Molecules; vol. 25; 4; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 75581-11-2, A common heterocyclic compound, 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, molecular formula is C8H9IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A DMF solution (8mL) of the o-substituted aryl iodide (0.36mmol), the o-bromobenzyl alcohol (0.36mmol) and norbornene (34mg, 0.36mmol) was added under nitrogen to a Schlenck-type flask, containing Pd(OAc)2 (4mg, 0.018mmol), the phosphine (0.036mmol), when required, and K2CO3 (124mg, 0.90mmol) or CsOPiv (211mg, 0.90). The reaction mixture was stirred at 105C for 24h. After cooling to room temperature the organic layer was diluted with EtOAc (20mL), washed twice with water (20mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the resulting residue was purified by flash chromatography on silica gel using mixtures of hexane-EtOAc as eluent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Della Ca, Nicola; Fontana, Marco; Xu, Di; Cremaschi, Mirko; Lucentini, Riccardo; Zhou, Zhi-Ming; Catellani, Marta; Motti, Elena; Tetrahedron; vol. 71; 37; (2015); p. 6389 – 6401;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 75581-11-2,Some common heterocyclic compound, 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, molecular formula is C8H9IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1,4-dioxa-spiro[4,5]dec-7-en-8-boronic acid pinacol ester (25.0 g, 93.9 mmol), 4-iodo-2-methylanisole (28.0 g, 113 mmol), 1,1?-bis(diphenylphosphino)ferrocenedichlorlopalladium(II) (1.38 g, 1.89 mmol), dioxane (470 mL) and 1MNa2CO3 (282 mL, 282 mmol) was degassed with 3 vacuum/N2 cycles, stirred at 50 C for 2.5 h, and then allowed to cool to a The mixture was diluted with ethyl acetate (500 mL) and washed with saturated NaHCO3 (500 mL x 2). The aqueous layers were back extracted with ethyl acetate (200 mL). The combined ethyl acetate extracts were dried (Na2SO4), filtered, concentrated and purified by silica gel chromatography (0-5% ethyl acetate in hexanes) to give 8-(4-methoxy-3-methylphenyl)-1,4- dioxaspiro[4.5]dec-7-ene (19.9 g, 81%). ?H NMR (400 MHz, DMSO-d6): 7.21-7.16 (m, 2H), 6.85 (d, 1H), 5.89-5.84 (m, 1H), 3.90 (s, 4H), 3.76 (s, 3H), 2.52-2.47 (m, 2H), 2.32 (br s, 2H),2.13 (s, 3H), 1.77 (t, 2H); MS: 261.1 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1-methoxy-2-methylbenzene, its application will become more common.

Reference:
Patent; METACRINE, INC.; SMITH, Nicholas D.; GOVEK, Steven P.; (192 pag.)WO2017/49177; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 75581-11-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75581-11-2 as follows.

General procedure: A DMF solution (8mL) of the o-substituted aryl iodide (0.36mmol), the o-bromobenzyl alcohol (0.36mmol) and norbornene (34mg, 0.36mmol) was added under nitrogen to a Schlenck-type flask, containing Pd(OAc)2 (4mg, 0.018mmol), the phosphine (0.036mmol), when required, and K2CO3 (124mg, 0.90mmol) or CsOPiv (211mg, 0.90). The reaction mixture was stirred at 105C for 24h. After cooling to room temperature the organic layer was diluted with EtOAc (20mL), washed twice with water (20mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the resulting residue was purified by flash chromatography on silica gel using mixtures of hexane-EtOAc as eluent.

According to the analysis of related databases, 75581-11-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Della Ca, Nicola; Fontana, Marco; Xu, Di; Cremaschi, Mirko; Lucentini, Riccardo; Zhou, Zhi-Ming; Catellani, Marta; Motti, Elena; Tetrahedron; vol. 71; 37; (2015); p. 6389 – 6401;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodo-1-methoxy-2-methylbenzene

General procedure: Similar conditions for performing a Negishi coupling reaction with 15 have previously been described.4 A round bottom flask plus stir bar were dried and flushed with Ar before adding 1-iodo-3-isopropylbenzene (0.404 g, 1.64 mmol; purchased from Combi-Blocks) and anhyd. DMF (3 mL). Reaction was vacuum purged and refilled with Ar (3x) before the addition of Pd2dba3 (50 mg, 0.16 mmol) and P(o-tolyl)3 (75 mg, 0.082 mmol). A suspension containing organozinc 15 (5.5 mL, 2.5 mmol, 1.5 equiv.) was carefully added via syringe so as to avoid aspirating unreacted zinc metal. Reaction was stirred overnight at room temperature under Ar. Reaction mixture was quenched with sat. NH4Cl and extracted with EtOAc (2 x 15 mL). Organic phase was washed with brine, dried over MgSO4, filtered, concentrated and dried under high vacuum. Crude was purified by flash chromatography eluting with 5% EtOAc/Hexanes resulting in a beige solid: 277 mg (42%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 75581-11-2.

Reference:
Article; Augustyn, Evan; Finke, Karissa; Zur, Arik A.; Hansen, Logan; Heeren, Nathan; Chien, Huan-Chieh; Lin, Lawrence; Giacomini, Kathleen M.; Colas, Claire; Schlessinger, Avner; Thomas, Allen A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 11; (2016); p. 2616 – 2621;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com