Category: 74128-84-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74128-84-0, name is 2-Bromo-1-iodo-3-methoxybenzene, A new synthetic method of this compound is introduced below., Safety of 2-Bromo-1-iodo-3-methoxybenzene

A mixture of 1-ethynyl-2-methylnaphthalene (3b) (500 mg, 3.6 mmol), 2-bromo-1-iodo-3-methoxybenzene (1.1 g, 3.6 mmol), Pd(PPh3)2Cl2 (105 mg, 0.15 mmol) and CuI (29 mg, 0.15 mmol), Et3N (5 mL) in THF (20 mL) was heated at 60 C for 2 h under nitrogen. The reaction mixture was cooled to room temperature and filtered through celite, and the precipitate was washed with ether. The organic layer was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography with ether and hexane (1 : 10) to give the title compound (661 mg, 63%) colorless crystals. mp 116-117 C; 1H-NMR (400MHz, CDCl3) delta8.56 (1H, d, J = 8.4 Hz), 7.82 (1H, d, J = 8.0 Hz), 7.76 (1H, d, J = 8.4 Hz), 7.59 (1H, t, J = 7.2 Hz), 7.47 (1H, t, J = 7.2 Hz), 7.38 (1H, d, J = 8.0 Hz), 7.34 (1H, d, J = 7.2 Hz), 7.30 (1H, t, J = 8.0 Hz), 6.90 (1H, d, J = 7.2 Hz), 4.08 (3H, s), 3.94 (3H, s); 13C-NMR (100MHz, CDCl3) delta156.6, 140.1, 133.8, 131.7, 128.7, 128.20, 128.18, 128.1, 127.6, 127.1, 126.2, 125.72, 125.67 119.2, 114.9, 111.7, 97.4, 91.4, 56.6, 21.8; IR (CHCl3)2936, 2837, 2203 cm-1; MS (EI) m/z (%, fragment) = 350 (100, M+), 307 (3.3, M+, -CH3O), 270 (7.2, M+,-Br); HRMS calcd for C20H15BrO: 350.0306. found 350.0314. Anal. Calcd for C20H15BrO: C, 68.39; H, 4.30. Found: C, 68.55; H, 4.03.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kadoya, Nobuaki; Murai, Masato; Ishiguro, Masako; Uenishi, Jun’Ichi; Uemura, Motokazu; Tetrahedron Letters; vol. 54; 6; (2013); p. 512 – 514;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 74128-84-0, name is 2-Bromo-1-iodo-3-methoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74128-84-0, Formula: C7H6BrIO

An oven-dried 10 mL microwave reaction vial which was equipped with a magnetic stir bar was sequentially charged with Pd2(dba)3 (2.9 mg, 0.003 mmol), SPhos (2.9 mg, 0.007 mmol), K3PO4 (203 mg, 0.96 mmol), (2,4,6-trimethyl-[1,1?-biphenyl]-3-yl)boronic acid (115 mg, 0.48 mmol), 2-bromo-1-iodo-3-methoxybenzene (100 mg, 0.32 mmol) and anhydrous toluene (0.64 mL) inside a glove-box. The vial was sealed and the reaction mixture was allowed to stir at 110 C. for 16 h. The reaction mixture was cooled and water (20 mL) was added. The mixture was extracted with EtOAc (3×25 mL) and the combined organic extracts were washed with brine, dried over Na2SO4, filtered and the solvent was removed with the aid of a rotary evaporator. The crude material was purified by gravity column chromatography (silica gel, 2:98 EtOAc:hexanes) to afford an off-white colored solid (0.106 g, 87% yield). H NMR (600 MHz, CDCl3) delta 7.41-7.38 (m, 2H), 7.38-7.28 (m, 2H), 7.18-7.14 (m, 2H), 7.03 (s, 1H), 6.86 (dd, 3JH,H=8.4 Hz, 4JH,H=1.2 Hz, 1H), 6.79 (dd, 3JH,H=7.8 Hz, 4JH,H=1.8 Hz, 1H), 3.93 (s, 3H), 2.03 (s, 3H), 1.97 (s, 3H), 1.63 (s, 3H).

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Reference:
Patent; Agency for Science, Technology and Research; Johannes, Charles W.; Robins, Edward G.; Jong, Howard; Lim, Yee Hwee; Chia, Saei Weng; Yang, Yong; Podichetty, Anil; (84 pag.)US2016/207034; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 74128-84-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74128-84-0, name is 2-Bromo-1-iodo-3-methoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-bromo-1-iodo-3-methoxybenzene (0.88 g, 2.81 mmol) obtained in Step B was dissolved in DCM (4 mL) andcooled to 0-5C. 1M BBr3 (8.4 mL, 8.43 mmol) was slowly added dropwise thereto, and the mixture was stirred at 0-5Cfor 1 hour and additionally stirred at room temperature for 1 hour. After termination of the reaction, the reaction solutionwas cooled to -20C and diluted by slowly adding methanol. The mixture was stirred at room temperature for 30 minutes.After addition of saturated NaHCO3 aqueous solution, the reaction solution was extracted with DCM. The organic layerwas dried with anhydrous magnesiumsulfate, concentrated under reduced pressure and purified by column chromatography(eluent, EtOAc/Hex = 1/5) to obtain the title compound (0.723 g, 86%).1H NMR (500 MHz, CDCl3) delta 7.43-7.39(m, 1H), 7.02-6.92 (m, 2H), 5.61 (s, 1H)

The synthetic route of 2-Bromo-1-iodo-3-methoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG Chem, Ltd.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; PAEK, Seung Yup; KANG, Seung Wan; KIM, Byung Gyu; LEE, Chang Seok; KIM, Sung Wook; LEE, Sang Dae; (369 pag.)EP3239143; (2017); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 74128-84-0, name is 2-Bromo-1-iodo-3-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Bromo-1-iodo-3-methoxybenzene

Under a nitrogen atmosphere, 31.3 g of 2-bromo-1-iodo-3-methoxybenzene,Phenyl dibenzo [b, d] furan-2-amine (26.0 g), A flask containing sodium-tert-butoxide (14.6 g) and toluene (200 ml) was heated to 90 C and bis [(tri-tertiary-butyl) phosphine] palladium (2.0 g) was added thereto. And refluxed under nitrogen for 24 hours.After cooling to room temperature, the mixture was filtered, and the solvent was distilled off under reduced pressure. The resulting solid was washed with acetonitrile to obtain 22.2 g of compound synthesis intermediate E

The synthetic route of 2-Bromo-1-iodo-3-methoxybenzene has been constantly updated, and we look forward to future research findings.