Category: 725266-66-0

Synthesis of tryptophan derivatives via a palladium-catalyzed N-heteroannulation was written by Dacko, Christopher A.;Akhmedov, Novruz G.;Soederberg, Bjoern C. G.. And the article was included in Tetrahedron: Asymmetry in 2008.SDS of cas: 725266-66-0 The following contents are mentioned in the article:

Tryptophan derivatives were prepared from 2-(2-nitrophenyl)-2-propen-1-yl substituted pyrazines, derived from Schoellkopf’s chiral auxiliary, using a palladium-catalyzed, carbon monoxide-mediated reductive N-heteroannulation reaction. A diastereomeric ratio of products ranging from 4:1 to >30:1 was observed This study involved multiple reactions and reactants, such as 1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0SDS of cas: 725266-66-0).

1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 725266-66-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The Mechanism of the ortho-Methylation of Nitrobenzenes by Dimethylsulfonium Methylide was written by Haiss, Peter;Zeller, Klaus-Peter. And the article was included in European Journal of Organic Chemistry in 2011.Related Products of 725266-66-0 The following contents are mentioned in the article:

Nitrobenzenes carrying an ortho substituent are selectively methylated at the free ortho position by reaction with dimethylsulfonium methylide. The importance of the ortho substituent is demonstrated by the failure of the methylation of nitrobenzene and 3- and 4-nitroanisole. This is explained by the out-of-plane geometry of the nitro group in the ortho-substituted derivative, which enables a specific interaction between the ylide and the nitro group favorable for attack of the methylide C atom at the neighboring free ortho position. As shown by appropriate deuterium-labeling studies, the addition is followed by an E1-like β-elimination with displacement of di-Me sulfide and subsequent protonation of the elimination product. This study involved multiple reactions and reactants, such as 1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0Related Products of 725266-66-0).

1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Related Products of 725266-66-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Intermediates in the synthesis of carboxyl-C¹⁴-labeled 3-hydroxyanthranilic acid was written by Ciereszko, Leon S.;Hankes, L. V.. And the article was included in Journal of the American Chemical Society in 1954.Recommanded Product: 725266-66-0 The following contents are mentioned in the article:

3,2-MeO(O₂N)C₆H₃CO₂H (I) (10 g.) and 15 g. SOCl₂ refluxed 1.5 h. on the water bath, the clear red solution dissolved in 50 cc. C₆H₆ and poured slowly and carefully with stirring into 200 cc. cold concentrated NH₄OH, the flask rinsed with 40 cc. Et₂O, the washings added to the NH₄OH solution, the mixture stirred 10 min., and the solid filtered off on a sintered glass funnel and washed successively with H₂O, EtOH, and Et₂O yielded 9.4 g. (94%) 3,2-MeO(O₂N)C₆H₃CONH₂ (II), colorless needles, m. 212°, very soluble in Me₂CO, but insoluble in H₂O, EtOH, Et₂O, and C₆H₆. It is recommended that the conversion of I to the acid chloride be carried out with SOCl₂ instead of PCl₅ which caused an explosion in one case. I (9.8 g.) in 200 cc. alk. 0.5N NaOCl stirred 3 h. at room temperature, the mixture filtered, the amber filtrate heated 0.5 h. at 80-90° and let stand overnight at room temperature, and the precipitate washed with H₂O and dried gave 7.5 g. (99%) 3,2-MeO(O₂N)C₆H₃NH₂ (III), bright yellow crystals, m. 124° (recrystallized from C₆H₆-ligroine, bright yellow needles, m. 124-4.5°). [The structure III had previously been assigned by Reverdin and Widmer (C.A. 8, 932) to a compound, m. 143°, obtained by the hydrolysis of 1 of the products isolated from a mixture produced by the nitration of m-MeOC₆H₄NHAc.] III (21 g.) in 300 cc. glacial AcOH treated gradually at 15° with 15 g. KNO₂ in 70 cc. ice-cold concentrated H₂SO₄, the resulting solution poured into 650 g. ice and H₂O, the mixture stirred 0.5 h., the excess HNO₂ destroyed with H₂NSO₃NH₄, the clear solution treated with 30 g. KI in 150 cc. H₂O, the mixture heated 1 h. on the water bath, and cooled, the liberated iodine removed with NaHSO₃, and the product filtered off, washed with H₂O, and dried gave 30.5 g. (88%) 3,2-MeO(O₂N)C₆H₃I (IV), reddish brown powder, m. 68-74°, which on short-path vacuum distillation gave pale yellow crystals, m. 81°. IV (2.7 g.) and 0.9 g. dry CuCN heated 2 h. at 180°, the mixture extracted with 25 cc. boiling C₆H₆, the extract diluted with 50 cc. ligroine, and the precipitate recrystallized from C₆H₆ and ligroine gave 3,2-MeO(O₂N)C₆H₃CN (V), white needles, m. 122°. IV (0.9 g.), 2.0 g. NaOH, 16 cc. H₂O, and 4 cc. EtOH refluxed 1.5 h. (evolution of NH₃), and the hot solution decolorized with C and acidified with HCl gave 1 g. I, m. 257°. This study involved multiple reactions and reactants, such as 1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0Recommanded Product: 725266-66-0).

1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 725266-66-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com