Category: 72373-82-1

Application of 72373-82-1, These common heterocyclic compound, 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compounds dibenzo[b,d]furan-2-ol (30g, 0.16mol), 1-chloro-2-fluoro-3-iodo-benzene (41.7g, 0.16mol) in 300ml DMF in a nitrogen atmosphere completely After dissolving, potassium carbonate (44.2 g, 0.32 mol) was added and the mixture was heated with stirring for 2 hours. The temperature was lowered to room temperature, and water was added to obtain a solid, which was purified by column chromatography (chloroform / hexane) to give Compound 1-A (60.5 g, yield: 90percent)

Statistics shows that 1-Chloro-2-fluoro-3-iodobenzene is playing an increasingly important role. we look forward to future research findings about 72373-82-1.

Reference:
Patent; LG Chem, Ltd.; Yoon Hong-sik; Hong Wan-pyo; Jeong Gyeong-seok; Kim Yeon-hwan; Yoon Hong-je; (49 pag.)KR2018/101265; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H3ClFI

[00343] Intermediate 13A. Ethyl l-(3-chloro-2-fluorophenyl)-lH-imidazole-4- carboxylate, 1 TFA: A mixture of l-chloro-2-fluoro-3-iodobenzene (0.549 g, 2.141 mmol), ethyl lH-imidazole-4-carboxylate (0.3 g, 2.141 mmol), copper(I) iodide (0.082 g, 0.428 mmol), L-proline (0.099 g, 0.856 mmol), and K2C03 (0.888 g, 6.42 mmol) in DMSO (4.28 mL) was vacuumed and back-filled with argon for three times, then capped and heated at 110 °C. After 20 h, the reaction mixture was cooled to rt and diluted with EtOAc. The organic layer was washed with H20, brine, dried over Na2S04, filtered, and concentrated. The crude product was then purified using reverse phase HPLC chromatography to yield the desired product (0.01 g, 1.2percent) as a colorless oil. MS(ESI) m/z: 269.0 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 72373-82-1.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.; WO2013/22818; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 72373-82-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 17A. Ethyl l-(3-chloro-2-fluorophenyl)-lH-imidazole-4- carboxylate, 1 HQ: A mixture of l-chloro-2-fluoro-3-iodobenzene (0.549 g, 2.141 mmol), ethyl lH-imidazole-4-carboxylate (0.3 g, 2.141 mmol), copper(I) iodide (0.082 g, 0.428 mmol), L-proline (0.099 g, 0.856 mmol), and K2C03 (0.888 g, 6.42 mmol) in DMSO (4.28 mL) was vacuumed and back-filled with argon for three times, then capped and heated at 110 °C. After 20 h, the reaction mixture was cooled to room temperature and diluted with EtOAc. The organic layer was washed with H20, brine, dried over Na2S04, filtered, and concentrated. The crude product was then purified using reverse phase HPLC chromatography to yield the desired product (0.01 g, 1.2percent) as a colorless oil. MS (ESI) m/z: 269.0 (M+H)+.Intermediate 17A. Ethyl l-(3-chloro-2-fluorophenyl)-lH-imidazole-4- carboxylate, 1 HQ: A mixture of l-chloro-2-fluoro-3-iodobenzene (0.549 g, 2.141 mmol), ethyl lH-imidazole-4-carboxylate (0.3 g, 2.141 mmol), copper(I) iodide (0.082 g, 0.428 mmol), L-proline (0.099 g, 0.856 mmol), and K2C03 (0.888 g, 6.42 mmol) in DMSO (4.28 mL) was vacuumed and back-filled with argon for three times, then capped and heated at 110 °C. After 20 h, the reaction mixture was cooled to room temperature and diluted with EtOAc. The organic layer was washed with H20, brine, dried over Na2S04, filtered, and concentrated. The crude product was then purified using reverse phase HPLC chromatography to yield the desired product (0.01 g, 1.2percent) as a colorless oil. MS (ESI) m/z: 269.0 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-2-fluoro-3-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.P.; CLARK, Charles G.; SMITH, II, Leon M.; ORWAT, Michael J.; JEON, Yoon; CORTE, James R.; WO2014/160668; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Chloro-2-fluoro-3-iodobenzene

(0112) A 500 mL flask was charged with 1-chloro-2-fluoro-3-iodobenzene (12.87 g, 65 mmol), [1,1′-biphenyl]-4-ylboronic acid (20 g, 78 mmol), potassium carbonate (8.98 g, 65 mmol), Pd(PPh3)4 (7.51 g, 6.5 mmol), toluene (280 ml), ethanol (140 ml) and water (140 ml). The resulting mixture was stirred, degassed and heated to 72C. for overnight. The reaction mixture was transferred into a separatory funnel, organic layer was separated, and aqueous layer was extracted with EtOAc. Combined organic layer was dried over Na2SO4, concentrated and the resulting residue was purified by column chromatography (EtOAc/heptane) to obtain 16.8 g (91% yield) of 3-chloro-2-fluoro-1,1′:4′,1”-terphenyl .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 72373-82-1, its application will become more common.

Some common heterocyclic compound, 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks

To a solution of 5-{4-[(S)-1-(3-fluoropropyl)pyrrolidin-3-yloxy]phenyl}-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-8,9-dihydro-7H-benzocyclohepten-2-ol (D’) (100.3 mg, 197.66 mumol), in dioxane (1 ml) and water (0.5 ml), was added 3-chloro-2-fluoroiodobenzene (60.83 mg, 237.19 mumol), Cs2CO3 (128.93 mg, 395.31 mumol) and Pd(dppf)Cl2 (9.68 mg, 11.86 mumol). The reaction mixture was heated at 70° C. for 6 hours, and partitioned between DCM and water. The aqueous phase was washed with DCM and organic phases were dried and concentrated under reduced pressure. The residue was purified by column chromatography eluting with a gradient of MeOH in DCM (0percent to 10percent) to give a solid which was further purified on strong cation exchange (SCX) column to give 18 mg (18percent) of 6-(3-chloro-2-fluorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulen-2-ol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 72373-82-1, its application will become more common.