Category: 7212-28-4

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7212-28-4 as follows. Formula: C8H8INO

General procedure: 0.3 g (1.56 mmol) of 7, 1.87 mmol of 3a-j and 0.32 g (2.34 mmol) of K2CO3 were combined and refluxed in 20 ml of acetone for 2 h. The solvent was evaporated under reduced pressure and the crude product was washed with water, filterred and dried. The pure product was obtained by recrystallization from petroleum ether and ethyl acetate.

According to the analysis of related databases, 7212-28-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu, Wukun; Hua, Jie; Zhou, Jinpei; Zhang, Huibin; Zhu, Haiyang; Cheng, Yanhua; Gust, Ronald; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 5008 – 5012;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 7212-28-4, name is 2-Iodo-N-phenylacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H8INO

General procedure: 0.4 g (1.61 mmol) of 10, 1.93 mmol of 3a-j and 0.55 g (4.01 mmol) of K2CO3 were combined and refluxed in 20 ml acetone for 2 h. Then the solvent was reduced under reduced pressure. The crude product was washed with water, filtered and dried, followed by recrystallization from petroleum ether and ethyl acetate.

The synthetic route of 2-Iodo-N-phenylacetamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Wukun; Hua, Jie; Zhou, Jinpei; Zhang, Huibin; Zhu, Haiyang; Cheng, Yanhua; Gust, Ronald; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 5008 – 5012;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7212-28-4 as follows. Recommanded Product: 2-Iodo-N-phenylacetamide

General procedure: 0.3 g (1.56 mmol) of 7, 1.87 mmol of 3a-j and 0.32 g (2.34 mmol) of K2CO3 were combined and refluxed in 20 ml of acetone for 2 h. The solvent was evaporated under reduced pressure and the crude product was washed with water, filterred and dried. The pure product was obtained by recrystallization from petroleum ether and ethyl acetate.

According to the analysis of related databases, 7212-28-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Liu, Wukun; Hua, Jie; Zhou, Jinpei; Zhang, Huibin; Zhu, Haiyang; Cheng, Yanhua; Gust, Ronald; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 5008 – 5012;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 7212-28-4,Some common heterocyclic compound, 7212-28-4, name is 2-Iodo-N-phenylacetamide, molecular formula is C8H8INO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of DDPT (0.5 g), 6a-j (1.57 mmol) and K2CO3 (0.45 g, 3.26 mmol) in acetone (20 mL) was refluxed for 2 h. The reaction mixture was evaporated in vacuo, and purified by column chromatography (CH2Cl2: AcOEt = 32:1) to give compounds 7a-j. 1.6.1. 2-(4-Deoxyl-4′-demethylpodophyllotoxin-oxy)-N-phenylacetamide(7a)The title compound wasobtained in 44.6% yield as a white solid: mp 210-212 C; IR numax (cm-1) 3337,3040, 2962, 2909, 2878, 2842, 1767, 1690, 1597, 1537, 1504, 1483, 1462, 1443,1418, 1331, 1240, 1224, 1156, 1037, 932; 1H NMR (300 MHz, CDCl3)delta 9.58 (s, 1H, ArNH), 7.63 (d, J = 7.9Hz, 2H, ArH), 7.36 (t, J =7.8 Hz, 2H, ArH), 7.13 (t, J = 7.3Hz, 1H, ArH), 6.69 (s, 1H, ArH), 6.53 (s, 1H, ArH), 6.42 (s, 2H, ArH), 5.96 (d,J = 6.8 Hz, 2H, -OCH2O-), 4.64-4.62 (m, 3H, -OCH2CO-, CH), 4.59-4.35(m, 1H, -OCH2-), 4.11-3.74 (m, 1H, -OCH2-), 3.82 (s, 6H,2 ¡Á CH3), 3.12-3.07 (m, 1H, -CH2-), 2.84-2.76 (m, 3H,-CH-, -CH2-); ESI calcd. 516.2 [M – H]-, found 516.0 [M -H]-. HRMS calcd. C29H27NO8Na [M +Na]+ 540.1634, found 540.1646 (parts per million error of 2.2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodo-N-phenylacetamide, its application will become more common.

Reference:
Article; Zhu, Xiong; Fu, Junjie; Tang, Yan; Gao, Yuan; Zhang, Shijin; Guo, Qinglong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 4; (2016); p. 1360 – 1364;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 7212-28-4, name is 2-Iodo-N-phenylacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks

EXAMPLE 146 Trans-2-carboxy-5,7-dichloro-4-(phenylaminocarbonylmethylamino)-1,2,3,4 -tetrahydroquinoline hydrochloride This material was prepared by the method given in Example 145 step a and b) using phenylaminocarbonylmethyliodide in place of benzyl bromide to yield the title compound as colourless crystals, m.p. 163-164.2 C. dec.; delta (360 MHz, DMSO) 1.93 (1H, ddd, J=13.3, 12.2 and 3.8 Hz, CHA CHB HC CHD), 2.73 (1H, dm, J=13.3 Hz, CHA CHB HC CHD), 4.00 (2H, 2d, J=16.2 Hz, NHCH2 CONHPh), 4.32 (1H, dd, J=12.2 and 3.8 Hz, CHA CHB HC CHD), 4.78 (1H, bs, CHA CHB HC CHD), 6.73 (1H, d, J=2.0 Hz, 6-H or 8-H), 6.92 (1H, d, J=2.0 Hz, 6-H or 8-H), 7.10 (1H, m, ArH), 7.18 (1H, s, ArNH), 7.35 (2H, m, 2 ArH), 7.60 (2H, m, 2 ArH), 9.5 (2H, bm, NH2), 10.72 (1H, m, CHD NHCH2). m/e (FAB+) 394 (M+1). Found C, 46.73; H, 4.28; N, 8.75; C18 H17 Cl2 N3 O3.1.9HCl requires C, 46.50; H, 4.32; N, 9.05%.

The synthetic route of 2-Iodo-N-phenylacetamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme, Ltd.; US5231102; (1993); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com