Category: 69113-59-3

Related Products of 69113-59-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69113-59-3, name is 3-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

N-(3-Cyanophenyl)benzylamine (, entry 14) The general procedure under argon was followed using copper(I) iodide (10 mg, 0.05 mmol), K3PO4 (425 mg, 2.00 mmol), benzylamine (131 muL, 1.20 mmol), 3-iodobenzonitrile (229 mg, 1.00 mmol), ethylene glycol (111 muL, 2.00 mmol) and 2-propanol (1.0 mL). Column chromatography using a solvent mixture (hexane/ethyl acetate=5/1, Rf=0.5) afforded N-(3-cyanophenyl)benzylamine (165 mg, 80% isolated yield) as light yellow solid. The spectral data (1H NMR) matched with the literature references and GC analysis indicated >95% purity.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.; US2003/65187; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 69113-59-3, These common heterocyclic compound, 69113-59-3, name is 3-Iodobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of Ar3In or (RC?C)3In (0.37mmol, ca. 0.18M in dry THF) was added to a mixture of MCM-41-N,N-Pd(0) (25mg, 1mol%) and aryl iodide (1mmol) in dry THF (2mL) under Ar. The resulting mixture was refluxed under Ar until the starting material had been consumed (TLC). After being cooled to room temperature, the mixture was diluted with Et2O (30mL) and filtered. The palladium catalyst was washed with DMF (2×5mL), Et2O (2×5mL) and reused in the next run. The filtrate was washed with sat. aq NaHCO3 (5mL), water (3×10mL) and dried over MgSO4, filtered, and concentrated under vacuum. The residue was purified by flash chromatography on silica gel to give the desired cross-coupling product.

Statistics shows that 3-Iodobenzonitrile is playing an increasingly important role. we look forward to future research findings about 69113-59-3.

Reference:
Article; Lei, Zhiwei; Liu, Haiyi; Cai, Mingzhong; Journal of Organometallic Chemistry; vol. 852; (2017); p. 54 – 63;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 69113-59-3, name is 3-Iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69113-59-3, HPLC of Formula: C7H4IN

3-Iodophenylamidoxime 3-Iodobenzonitrile (1145 mg, 5 mmol) and 5M hydroxylamine hydrochloride (1 mL, 5 mmol) in ethanol (5 mL) and 1Nsodium hydroxide (5 mL, 5 mmol), were heated at reflux for 2.5 hours. Standard work up followed by column chromatography afforded 920 mg (70.2%) of 3-iodophenylamidoxime.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Wagenen, Bradford Van; Stormann, Thomas M.; Moe, Scott T.; Sheehan, Susan M.; McLeod, Donald A.; Smith, Daryl L.; Isaac, Methvin Benjamin; Slassi, Abdelmalik; US2003/55085; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

69113-59-3, name is 3-Iodobenzonitrile, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 3-Iodobenzonitrile

Example 173-Trimethylsilanylethynyl-benzonitrile 3-Iodo-benzonitrile (10.0 g, 43.7 mmol), trilmethylsilane acetylene (5.57 g, 56.8 mmol), palladium tetrakis triphenylphosphine (2.02 g, 1.75 mmol), and copper iodide (1.0 g, 5.24 mmol) in triethylamine (120 mL) was stirred for 12 h. The reaction was concentrated and purified by column chromatography to afford the title product (9.35 g, quantitative yield) as a brown oil.1H NMR (300 MHz, CDCl3): delta (ppm) 7.76 (t, 1H), 7.71 (dd, 1H), 7.63 (dd, 1H), 7.28 (t, 1H), 0.26 (s, 9H).

The synthetic route of 69113-59-3 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69113-59-3, name is 3-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 69113-59-3

The title compound (39 mg, 67.3 %, yellow solid) was obtained from [4- (5-] tributylstannanyl-isoxazol-3-ylmethyl)-piperazine-1-carboxylic acid ethyl ester (106 mg, 0.2 mmol) and Pd (PPh3) [2C12] (0.2 mg) with 3-iodobenzonitrile (38.9 mg, 0.17 mmol) in dioxane [(LML)] at [110 C OVEMIGHT. LH-NMR] (CDC13) 8 (ppm): [8.] 07 (s, 2H), 8.02 (d, 1H), 7.73 (d, 1H), 7.62 (t, lH) 6.68 (s, [1H),] 4.14 (q, 2H), 3.68 (s, 2H), 3.51 (m, 4H), 2.51 (m, 4H) and 1. 26 (t, 3H).

The synthetic route of 69113-59-3 has been constantly updated, and we look forward to future research findings.

Related Products of 69113-59-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69113-59-3 name is 3-Iodobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirred solution of the corresponding beta-enaminone 7 (1.8 mmol) in DMF (0.45 mL) at room temperature under argon was added (i-Pr)2NH (3.6 mL), PdCl2(PPh3)2 (0.036 mmol) and CuI (0.036 mmol) in turn and the reaction mixture was stirred for 10 min. The appropriate aryl iodide (2.8 mmol) was then added and the resulting mixture was stirred at room temperature for approximately 3-5 h (Note that stirring was continued until beta-enaminone 7 was completely consumed as monitored by routine TLC). After the reaction was over, ethyl acetate (50 mL) was added, and the resulting solution was washed with 0.1 N HCl (10 mL) and subsequently with a saturated NH4Cl solution (10 mL) in a separatory funnel. After the layers were separated, organic phase was dried over MgSO4 and evaporated on a rotary evaporator to give the crude product, which was purified by flash chromatography on silica gel using hexane/ethyl acetate (9:1 followed by 4:1) as the eluent to afford the corresponding beta-enaminone 4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodobenzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Karabiyikoglu, Sedef; Kelgokmen, Yilmaz; Zora, Metin; Tetrahedron; vol. 71; 25; (2015); p. 4324 – 4333;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 69113-59-3, These common heterocyclic compound, 69113-59-3, name is 3-Iodobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedure: Palladium Catalyzed Heck Reaction (Conventional Heating) Sodium acetate (3 mmol), substituted piperazine (1.5 mmol), iodo-benzene or bromo-benzene (1 mmol) and tetrabutylammonium chloride (2 mmol) were dissolved in dimethylacetamide (7 mL) and stirred until all reagents dissolved. Palladium(II) acetate (0.25 mmol) was added and the reaction mixture was stirred at 100 C. for 24 h. The reaction mixture was then cooled to room temperature, diluted with dichloromethane and quenched with water. The organic phase was dried, filtered and concentrated in vacuo, then chromatographed in ethyl acetate in hexanes to yield the desired product.; The following compounds were made in this manner: Example Structure Name Yield 14.1 2-{4-[(2E)-3-(3-cyanophenyl)prop-2- enoyl]piperazine-1-yl}nicotinonitrile 53%

Statistics shows that 3-Iodobenzonitrile is playing an increasingly important role. we look forward to future research findings about 69113-59-3.

Reference:
Patent; AstraZeneca AB; NPS PHARMACEUTICALS; US2007/49578; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 69113-59-3, A common heterocyclic compound, 69113-59-3, name is 3-Iodobenzonitrile, molecular formula is C7H4IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of n-butyllithium inn-hexane (1.6 M, 7.4 mL, 11.9 mmol) was added to a solutionof m-carborane (1.50 g, 10.8 mmol) in l,2-dimethoxyethane(DME) (12 mL) at 0C under Ar atmosphere, and the mixture was stirred at 0 C for 30 min. Copper(I) chloride (10 mg,104 mmol) was added to the reaction mixture at room temperature. After 1 h, pyridine (3.8 mL) and substituted iodobenzene(11.9 mmol) were added, and the mixture was stirred at 80 C for 2.5 h. After cooling, the reaction mixture was diluted withether, and insoluble materials were filtered off through celite.The filtrate was washed successively with 5% sodium thiosulfate, 2 M hydrochloric acid, and brine, dried over sodiumsulfate, and evaporated. The residue was purified by silicagel column chromatography (eluent: n-hexane-ethyl acetate,20 : 1) to give 10-12.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Mori, Shuichi; Takagaki, Ryohei; Fujii, Shinya; Urushibara, Ko; Tanatani, Aya; Kagechika, Hiroyuki; Chemical and Pharmaceutical Bulletin; vol. 65; 11; (2017); p. 1051 – 1057;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 69113-59-3 as follows. Product Details of 69113-59-3

General procedure: Vial (C2) was loaded with aryl iodide/bromide (0.5 mmol), Pd(PPh3)4 (29 mg, 5 mol %), Et3N(139 muL, 1 mmol) and cyanamide (63 mg, 1.5 mmol). To vial (C1) was added Mo(CO)6 (138mg, 0.5 mmol) and thereafter 1,4-dioxane (3+3 mL) was added to C1 and C2. The two vials were capped with a gas tight cap and DBU (224 muL, 1.5 mmol) was added to C1. The sealed double vial was heated in a heat-block (65 C for iodides and 85 C for bromides) for 20 h with vigorous stirring.

According to the analysis of related databases, 69113-59-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mane, Rajendra S.; Nordeman, Patrik; Odell, Luke R.; Larhed, Mats; Tetrahedron Letters; vol. 54; 50; (2013); p. 6912 – 6915;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 69113-59-3,Some common heterocyclic compound, 69113-59-3, name is 3-Iodobenzonitrile, molecular formula is C7H4IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In an argon-filled glovebox, an oven-dried Schlenk tube equipped with a Teflon stir bar was charged with CuI (9.5 mg, 0.05 mmol, 5 mol%) followed by anhydrous toluene (2.0 ml), secondary phosphine (1.00 mmol), and L4 (49.54 mg, 0.30 mmol, 30 mol%). The solution was stirred for 5-10 min. Then the (hetero)aromatic bromide (1.00 mmol) and KOtBu (224.42 mg, 2.0 mmol) were added at once followed by anhydrous toluene/THF (0.5 mL/0.5 mL). The Schlenk tube was sealed with a Teflon valve and the reaction mixture was stirred at 100 C for 24 h. The reaction mixture was then cooled to room temperature and filtered with dichloromethane to remove any insoluble residues. The filtrate was concentrated in vacuo; the residue was purified by flash chromatography on silica to obtain the analytically pure product (kept under argon).

The synthetic route of 69113-59-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Chun-Jing; Lue, Jing; Zhang, Zhi-Xun; Zhou, Kun; Li, Yan; Qi, Guang-Hui; Research on Chemical Intermediates; vol. 44; 7; (2018); p. 4547 – 4562;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com