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In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-iodobenzaldehyde, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 689291-89-2, name is 5-Bromo-2-iodobenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 689291-89-2, COA of Formula: C7H4BrIO

Compound 12 (32 mg, 0.10 mmol), 41 (55.6 mg, 0.103 mmol), PdCl2(PPh3)2 (3.6 mg, 0.0051 mmol), and CuI (1.96 mg, 0.0103 mmol) were added to Et3N (6 mL). The solution was bubbled with N2 at rt for 5 min and then stirred at rt under N2 protection for 3 h. After the reaction was completed as checked by TLC analysis, the solvent was removed by rotary evaporation. The resulting residue was diluted with CHCl3. The mixture was filtered through a MgSO4 pad. The solution obtained was sequentially washed with HCl (aq 10%) and brine. The organic layer was dried over MgSO4 and concentrated under vacuum to give crude 51, which was further purified by silica flash column chromatography (hexanes/CH2Cl2, 7:3) to yield compound 51 (60 mg, 0.083 mmol, 81%) as a white solid. Mp 82-83 C; IR (KBr) 2918, 2851, 2207, 1690, 1631, 1603, 1583, 1552, 1533, 1513, 1497, 1469, 1420 cm-1; 1H NMR (CDCl3, 500 MHz) delta 10.66 (s, 1H), 8.07 (d, J=1.5 Hz, 1H), 7.69 (dd, J=8.0, 1.5 Hz, 1H), 7.64 (d, J=8.5 Hz, 2H), 7.60 (d, J=8.5 Hz, 2H), 7.49 (d, J=8.0 Hz, 1H), 7.02 (s, 1H), 7.01 (s, 1H), 4.05-4.01 (m, 4H), 1.89-1.83 (m, 4H), 1.60-1.46 (m, 4H), 1.30-1.26 (m, 24H), 0.89-0.86 (m, 6H); 13C NMR (CDCl3, 125 MHz) delta 190.9, 154.3, 154.0, 137.2, 136.8, 134.3, 132.24, 132.20, 130.3, 128.5, 125.9, 123.4, 118.7, 116.7, 116.4, 114.1, 113.5, 111.8, 94.3, 93.8, 90.5, 90.2, 69.8, 69.6, 32.1, 29.9, 29.82, 29.76, 29.6, 29.5, 29.4, 26.3, 22.9,14.3; HRMS (CI) m/z calcd for C44H52BrNO3 721.3131, found 722.3139 [M+H]+.

Reference:
Article; Zhou, Ningzhang; Wang, Li; Thompson, David W.; Zhao, Yuming; Tetrahedron; vol. 67; 1; (2011); p. 125 – 143;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Research on new synthetic routes about 689291-89-2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 689291-89-2, name is 5-Bromo-2-iodobenzaldehyde, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H4BrIO

3.11 g (10 mmol) of 5-bromo-2-iodobenzaldehyde, 1.44 g (10 mmol) of 8-aminoquinoline, 0.23 g (0.25 mmol) of Pd2(dba)3, 0.28 g (0.5 mmol) of dppf, and 2.76 g (20 mmol) of K2CO3 were dissolved in 250 mL of toluene, and then, the mixture was stirred at a temperature of 80 C. for 24 hours. The reaction solution was cooled to ambient temperature, immediately filtered through silica, and the filtrate was dried under reduced pressure. Then, 2.66 g (20 mmol) of AlCl3 was added thereto and dissolved in 300 mL of toluene, followed by stirring at 80 C. for 24 hours. The reaction solution was cooled to ambient temperature, and then subjected to an extraction process three times by using 60 mL of water and 60 mL of diethyl ether. An organic layer obtained therefrom was dried by using magnesium sulfate and the residual obtained by evaporating a solvent therefrom was separation-purified by silica gel column chromatography to obtain 1.23 g (yield: 40%) of Intermediate 3-1. The obtained compound was identified by LC-MS. C16H9BrN2;M+1 309.16

Reference:
Patent; SAMSUNG DISPLAY CO., LTD.; Sim, Munki; Park, Junha; Lee, Hyoyoung; Kim, Youngkook; Hwang, Seokhwan; (121 pag.)US2019/44072; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Analyzing the synthesis route of 689291-89-2

The synthetic route of 5-Bromo-2-iodobenzaldehyde has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 689291-89-2, name is 5-Bromo-2-iodobenzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 689291-89-2

To an oven-dried flask protected under a N2 atmosphere were charged compound 12 (540 mg, 1.74 mmol), trimethylsilylacetylene (0.68 g, 6.9 mmol), PdCl2(PPh3)2 (60 mg, 0.085 mmol), CuI (30 mg, 0.16 mmol), and Et3N (10 mL). The solution was bubbled by N2 at rt for 5 min and then heated to 60 C under stirring and N2 protection overnight. After the reaction was complete as checked by TLC analysis, the solvent was removed by rotary evaporation. The resulting residue was diluted with CHCl3. The mixture was filtered through a MgSO4 pad. The solution obtained was sequentially washed with HCl (aq. 10%) and brine. The organic layer was dried over MgSO4 and concentrated under vacuum to give crude 20, which was further purified by silica flash column chromatography (hexanes/CH2Cl2, 4:1) to yield compound 20 (518 mg, 1.74 mmol, 100%) as a colorless oil.

The synthetic route of 5-Bromo-2-iodobenzaldehyde has been constantly updated, and we look forward to future research findings.