Category: 68507-19-7

68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: iodides-buliding-blocks

3-iodo-4-methoxybenzoic acid (1.00 g, 7.19 mmol) was dissolved in SOCl2 (12.0 mL) and stirred at 80 C (22 h). Next, SOCl2 was removed in vacuo and azeotroped twice with benzene to give 57 (0.700 g, 2.36 mmol, 32%) as a white solid. 1H-NMR (400 MHz) CDC13: 8.50 (s, 1 H), 8.12-8.10 (d, 1 H), 6.88-6.86 (d, 1 H), 3.99 (s, 3 H); ,3C-NMR (100 MHz) CDC13: 165.1, 162.8, 141.9, 133.2, 126.3, 109.4, 85.2, 56.2.

The synthetic route of 68507-19-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; J-PHARMA CO., LTD.; WEMPE, Michael, F.; ENDOU, Hitoshi; WO2012/48058; (2012); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 68507-19-7,Some common heterocyclic compound, 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, molecular formula is C8H7IO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 9. (3 -Difluoro-5-(5-methyl-[l ,2,41triazolo[l ,5-alpyrimidin-7-yl)piperidin- l-yl)(3-iodo-4-methoxy hen l)methanone. To a solution of 7-(5,5-difluoropiperidin-3-yl)-5-methyl-[l ,2,4]triazolo[l,5- a]pyrimidine (35 mg, 0.10 mmol) in DCM (0.32 mL) was added TEA (15.94 mu, 0.1 1 mmol), 3-iodo-4-methoxybenzoic acid (26.50 mg, 0.10 mmol), HOBt (17.51 mg, 0.1 1 mmol) and EDCI (21.92 mg, 0.1 1 mmol). The reaction was stirred at rt for 16 h. The crude reaction was filtered and the residue was purified by preparative reverse phase HPLC to afford the title compound (14 mg, 29%). 1H NMR (400 MHz, CDC13) delta = 8.58 (s, 1H), 7.95 (d, J = 1.96 Hz, 1H), 7.50 (dd, J = 8.41 , 2.15 Hz, 1H), 6.94 (br s, 1H), 6.86 (d, J = 8.61 Hz, 1H), 4.52 – 4.85 (m, 1H), 4.03 (br s, 2H), 3.88 – 3.99 (m, 3H), 3.23 – 3.58 (m, 2H), 2.65 – 2.76 (m, 5H), [M+H] = 514.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Iodo-4-methoxybenzoic acid, its application will become more common.

Application of 68507-19-7, A common heterocyclic compound, 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, molecular formula is C8H7IO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 50 ml_, round-bottom flask equipped with a magnetic stirbar was charged with 3-iodo-4- methoxybenzoic acid (500 mg, 1.97 mmol), HOBT (482 mg, 3.15 mmol) and EDC (567 mg, 2.96 mmol). The reagents were dissolved in 15 ml. CH2CI2 and the solution was allowed to stir for 15 min. Subsequently, isoindoline (0.447 ml_, 3.94 mmol) and TEA (0.819 ml_, 5.91 mmol) were added to the reaction vessel and the solution was allowed to stir for 5 h. Upon completion, the solvent was removed under reduced pressure and the residue was purified via flash chromatography on silica gel to afford 490 mg (65%) of the title compound.

The synthetic route of 68507-19-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH LLC; LI, David, Zenan; O’NEIL, Steven, Victor; SPRINGER, Dane, Mark; ZEGARELLI, Benjamin, Miller; WO2010/124047; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 68507-19-7, These common heterocyclic compound, 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Standard conditions: iodobenzoic acid (0.55 mmol) , HP(0)Ph2, base, Pd/C, 0 (10 mL) , conventional heating, 100 C, 1 h. b 70 C.

Statistics shows that 3-Iodo-4-methoxybenzoic acid is playing an increasingly important role. we look forward to future research findings about 68507-19-7.

Reference:
Patent; PAUL SCHERRER INSTITUT; RANOCCHIARI, Marco; RUMMELT, Stephan; VAN BOKHOVEN, Jeroen A.; WO2013/117440; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H7IO3

[00164] To 26.9 mg PdCl2(dppf).CH2Cl2 in a reaction tube under nitrogen were added 4 ml dioxane, 0.43 ml (3 mmol) triethylamine, 0.35 ml (2.4 mmol) pinacolborane and 277 mg (1.0 mmol) 3-iodo-4-methoxybenzoic acid. The reaction solution was stirred at room temp. to ensure that all the phenolic groups had reacted with pinacolborane and the hydrogen evolved was flushed out of the reaction tube with argon. The reaction solution was warmed to 80 C. with stirring in an oil bath for 8 h. An aliquot (0.3 ml) was removed from the reaction solution, extracted into ethyl acetate, washed with dilute sulphuric acid and then several times with water and analysed by gc (fid detector, SGE HT5 capillary column). There was only one peak in the gc at retention time longer than that for 3-iodo-4-methoxybenzoic acid and that was confirmed by gc/ms to be due to the desired arylboronic acid pinacol ester.

According to the analysis of related databases, 68507-19-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 68507-19-7

Methyl 3-iodo-4-methoxybenzoate (29.2 g, 0.1 mol) was suspended in EtOH (150 mL), the solution of NaOH (4.4 g, 0.11 mol) was added in one portion. The mixture was stirred and heated at 40C overnight, then cooled, diluted with water (400 mL). 3-Iodo-4-methoxybenzoic acid was precipitated with conc. HCl, filtered off, washed with cold water, and dried over P4O10. The acid was suspended in CHCl3 (150 mL), and SOCl2 (9.5 mL, 0.13 mmol) was added. The mixture was stirred overnight, then evaporated and the residue was distilled under reduced pressure to give the desired acid chloride as a solid (mp ca. 50C, bp 145-150C/1 Torr). Yield 18.2 g (61%).

The synthetic route of 68507-19-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; OXFORD GENE TECHNOLOGY IP LIMITED; EP1506959; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 68507-19-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Dissolve 6-methoxy-naphthalen-1-yl)- [4- (2-piperidin-1-yl-ethoxy)-phenyl]- methanone-2-boronic acid (433 mg. , 1.0 mmoles) and 3-iodo-4-methoxybenzoic acid (556 mg. , 2.0 mmoles) in 8 ml of ethanol and add a slurry of 500 mg. of 10% palladium on carbon in 3 ml ethanol followed by 840 mg of sodium carbonate. Flush the vial with nitrogen and seal. Heat the mixture at 72 degrees for 24 hours. Cool, filter, wash the solid with ethanol and discard the solid. Purifty the filtrate on an SCX column, washing with methanol and eluting the product with 2N ammonia/methanol. Evaporate the solvent and purify on a silica column, eluting the impurities with a 0-10% methanol/methylene chloride gradient, then eluting the product with 20% methanol/methylene chloride to give 56 mg, 10%, of 3-methoxy-4- {6-methoxy-1- [4- (2-piperidin-1-yl-ethoxy)-benzoyl]- naphthalen-2-yl}-benzoic acid. Convert 3-methoxy-4- {6-methoxy-1- [4- (2-piperidin-1-yl-ethoxy)-benzoyl]- naphthalen-2-yl}-benzoic acid (56 mg) to the HCl salt and dissolve in methylene chloride. Chill the solution in ice and add excess boron tribromide in portions. Stir at 0 degrees for 1 hour, then at room temperature for 1 hour. Add a few drops of boron tribromide and stir for another 1/2hour. Quench the mixture with saturated sodium bicarbonate and wash the water layer with a solvent composed of a 3/1 mixture of chloroform/isopropanol. Adjust the pH of the water layer to 7 and extract with the organic solvent. Combine the organic layers, dry over 3a molecular sieves and evaporate to a solid. Purify on an SCX column, eluting with 2N ammonia/methanol to give 16 mg (30%) of the title compound.

The synthetic route of 3-Iodo-4-methoxybenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/73205; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68507-19-7, Formula: C8H7IO3

PyBop (675mg, 1.297mmol) and DIPEA (0.3mL) was added to a 0C solution of diamine (127mg, 1.174mmol) and acid (360mg,.1.295mmol) in DMF (3.0mL) under nitrogen. The solution was slowly warmed to room temperature. After 24 hours, the reaction solution was poured into saturated aqueous NaHC03 (20mL) and extracted with EtOAc (2x20mL). The organic layer was washed with brine(2x20mL), dried over MgSO,, filtered and concentrated. The crude solid was purified on a Combiflash Rf using Si02 with CH2CI2/MeOH to afford 367mg (85%) of amide product as a white solid. A suspension of the amide (294mg, 0.779mmol) in AcOH (8.0mL) was heated to reflux. After 24 hours, the solution was cooled to room temperature and concentrated in vacuo to a tan solid. The crude solid was purified via Combiflash Rf using Si02 with CH2CI2/Me0H to afford 2-(3-iodo-4-methoxyphenyl)- 1 H-benzo[d]imidazole (193mg, 69%) as a colorless solid.

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Reference:
Patent; REGENTS OF THE UNIVERSITY OF MINNESOTA; HARRIS, Reuben S.; HARKI, Daniel A.; PERKINS-HARKI, Angela L.; CARPENTER, Michael A.; LI, Ming; WO2013/74059; (2013); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68507-19-7, name is 3-Iodo-4-methoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7IO3

General procedure: To a solution of the alcohol (1 equiv) in dried THF at 0 C under a nitrogen atmosphere was added the acid (1.5 equiv) and triphenylphosphine (1.7 equiv), respectively. Then diisopropyl azodicarboxylate (1.7 equiv) was added slowly. The reaction mixture was stirred overnight, quenched with saturated NaHCO3, concentrated, and extracted with ethyl acetate for three times. The combined organic phase was dried over Na2SO4, concentrated, and the residue was purified with column chromatography to give the substrate in 60-85% yield.

The synthetic route of 68507-19-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xing, Xiangyou; Zhao, Yaohong; Xu, Chen; Zhao, Xinyang; Wang, David Zhigang; Tetrahedron; vol. 68; 36; (2012); p. 7288 – 7294;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com