Category: 6828-35-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6828-35-9, name is 5-Chloro-2-iodoaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloro-2-iodoaniline

1 mmol of 5-chloro-2-iodoaniline was added to the reaction vessel, 3 mL of aqueous ammonia at 12 mol / L and 1 mmol of benzaldehyde were added 0.1 mmol of copper chloride, 0.1 mmol of proline lithium (proline lithiumas) Sodium hydroxide 3 mmol, water 3 mL. Placed in a microwave reactor at 150 w of power heated to 100 C for 15 min continuous reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The product was purified by column chromatography to give a white solid in 86% yield.

The synthetic route of 6828-35-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fujian Medical University; Ke Fang; Zhang Peng; Xu Jianhua; Wu Wen; Zheng Yu; Wu Lixian; (9 pag.)CN106866543; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 6828-35-9, The chemical industry reduces the impact on the environment during synthesis 6828-35-9, name is 5-Chloro-2-iodoaniline, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of 2-iodo aniline/2-iodo phenol (0.25 mmol), Pd-NHC (5 mg, 2 mol%), Mo(CO)6 (0.50 mmol, 132 mg) was taken in round bottomed flask and backfilled with nitrogen three times. Alkyne (0.50 mmol), DMF (2 ml) and Me2NH (4 equiv) were added to the reaction mixture via syringe. The reaction mixture was heated at 95 C until the completion of the reaction. Afterwards, the reaction mixture was poured into the water and extracted with ethyl acetate (3¡Á10 ml). The organic phase was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified through column chromatography using ethyl acetate and petroleum ether as eluents.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ghosh, Prasanjit; Nandi, Aritra Kumar; Das, Sajal; Tetrahedron Letters; vol. 59; 21; (2018); p. 2025 – 2029;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

6828-35-9, name is 5-Chloro-2-iodoaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 6828-35-9

General procedure: A mixture of 2-iodo aniline/2-iodo phenol (0.25 mmol), Pd-NHC (5 mg, 2 mol%), Mo(CO)6 (0.50 mmol, 132 mg) was taken in round bottomed flask and backfilled with nitrogen three times. Alkyne (0.50 mmol), DMF (2 ml) and Me2NH (4 equiv) were added to the reaction mixture via syringe. The reaction mixture was heated at 95 C until the completion of the reaction. Afterwards, the reaction mixture was poured into the water and extracted with ethyl acetate (3¡Á10 ml). The organic phase was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified through column chromatography using ethyl acetate and petroleum ether as eluents.

The synthetic route of 6828-35-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ghosh, Prasanjit; Nandi, Aritra Kumar; Das, Sajal; Tetrahedron Letters; vol. 59; 21; (2018); p. 2025 – 2029;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 6828-35-9,Some common heterocyclic compound, 6828-35-9, name is 5-Chloro-2-iodoaniline, molecular formula is C6H5ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

c) To a stirred solution of 1-(4-ethynylbenzyl)-3,5-dimethyl-1 H-pyrazol-4-yl-acetic acid tert.- butyl ester (4.4g) and 5-chloro-2-iodophenylamine (3.4 g) in tetrahydrofuran (100 ml) at room temperature is added diisopropylethylamine (5.8 ml). The reaction is degassed and put under argon. Copper(l)iodide (260 mg) and bis(triphenylphosphine)palladiumdichloride (475 mg) are added. After 18 h, the reaction mixture is absorbed onto Extrelut and purified by flash chromatography (7:3 isocratic – cyclohexane:ethyl acetate) to yield a solid (4.3g; HPLC retention time 1.66 min (Method J)). The solid (4.2 g) is dissolved in N-methyl-2-pyrrolidone (25 ml) and the solution degassed and put under argon. Potassium tert-butoxide (4.1 g) is added and the reaction is then heated to 50C. After 15 h, further potassium tert-butoxide (1.0 g) is added. After 15 h the reaction temperature is increased to 75C. After 3 h, the reaction mixture is allowed to cool to room temperature and a copious amount of water is added. The reaction mixture is extracted twice with ethyl acetate and the aqueous phase is acidified to pH 3 with 1 M aqueous hydrochloric acid. The resultant precipitate is filtered off and triturated with hot acetonitrile to yield (1-[4-(6-Chloro-1 H-indol-2-yl)-benzyl]-3,5-dimethyl- 1 H-pyrazol-4-yl)-acetic acid (2.0 g; [M+H] = 394; HPLC retention time 1.51 min (Method E)).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-2-iodoaniline, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MARTYRES, Domnic; ANDERSKEWITZ, Ralf; HOENKE, Christoph; KRIEGL, Jan; OOST, Thorsten; RIST, Wolfgang; SEITHER, Peter; WO2012/130633; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

6828-35-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6828-35-9, name is 5-Chloro-2-iodoaniline, This compound has unique chemical properties. The synthetic route is as follows.

To a suspension of 5-chloro-2-iodoaniline (18.7 g, 0.074 mol, 1.0 eq.) in 500 mL of water was added hydroxylamine hydrochloride (18.5 g, 0.27 mol, 3.6 eq.), sodium sulfate (84.0 g, 0.59 mol, 8.0 eq.), chloral hydrate (14.7 g, 0.89 mol, 1.2 eq.) and 2N aqueous hydrochloric acid (25 mL). The mixture was stirred at 70 C for 18 h, then allowed to cool to room temperature. The resulting mixture was extracted with EtOAc (400 mL X 3) and the combined organic layers were dried (Na2S04), filtered and concentrated to afford compound 2 (17.0 g, 72.1% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LUDWIG INSTITUTE FOR CANCER RESEARCH LTD; GAHMAN, Timothy; SHIAU, Andrew; KOLODNER, Richard; (234 pag.)WO2017/51251; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com