Category: 638-45-9

Sil, Diptesh published the artcileSelf-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents, SDS of cas: 638-45-9, the publication is Molecules (2022), 27(8), 2441, database is CAplus and MEDLINE.

Conformationally restrained polyamine analog PG11047 is a well-known drug candidate that modulates polyamine metabolism and inhibits cancer cell growth in a broad spectrum of cancers. Here, we report a structure-activity relationship study of the PG11047 analogs (HPGs) containing alkyl chains of varying length, while keeping the unsaturated spermine backbone unchanged. Synthesis of higher sym. homologues was achieved through a synthetic route with fewer steps than the previous route to PG11047. The amphiphilic HPG analogs underwent self-assembly and formed spherically shaped nanoparticles whose size increased with the hydrophobic alkyl group′s increasing chain length. Assessment of the in vitro anticancer activity showed more than an eight-fold increase in the cancer cell inhibition activity of the analogs with longer alkyl chains compared to PG11047 in human colon cancer cell line HCT116, and a more than ten-fold increase in human lung cancer cell line A549. Evaluation of the inhibition of spermine oxidase (SMOX) showed no activity for PG11047, but activity was observed for its higher sym. homologues. Comparison with a reference SMOX inhibitor MDL72527 showed nine-fold better activity for the best performing HPG analog.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C15H15OP, SDS of cas: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Geonho published the artcileSynthesis and Characterization of Diketopyrrolopyrrole-Based Aggregation-Induced Emission Nanoparticles for Bioimaging, Recommanded Product: 1-Iodohexane, the publication is Molecules (2022), 27(9), 2984, database is CAplus and MEDLINE.

Conventional fluorescent dyes have the property of decreasing fluorescence due to aggregation-caused quenching effects at high concentrations, whereas aggregation-induced emission dyes have the property of increasing fluorescence as they aggregate with each other. In this study, diketopyrrolopyrrole-based long-wavelength aggregation-induced emission dyes were used to prepare biocompatible nanoparticles suitable for bioimaging. Aggregation-induced emission nanoparticles with the best morphol. and photoluminescence intensity were obtained through a fast, simple preparation method using an ultrasonicator. The optimally prepared nanoparticles from 3,6-bis(4-((E)-4-(bis(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)phenyl)-2,5-dihexyl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (DP-R2) with two functional groups having aggregation-induced emission properties and addnl. donating groups at the end of the triphenylamine groups were considered to have the greatest potential as a fluorescent probe for bioimaging. Furthermore, it was found that the tendency for aggregation-induced emission, which was apparent for the dye itself, became much more marked after the dyes were incorporated within nanoparticles. While the photoluminescence intensities of the dyes were observed to decrease rapidly over time, the prepared nanoparticles encapsulated within the biocompatible polymers maintained their initial optical properties very well. Lastly, when the cell viability test was conducted, excellent biocompatibility was demonstrated for each of the prepared nanoparticles.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watanabe, Masaki published the artcileIncreased Molecular Flexibility Widens the Gap between K_i and K_d values in Screening for Retinoid X Receptor Modulators, Quality Control of 638-45-9, the publication is ACS Medicinal Chemistry Letters (2022), 13(2), 211-217, database is CAplus and MEDLINE.

Screening for small-mol. modulators targeting a particular receptor is frequently based on measurement of K_d, i.e., the binding constant between the receptor and the compound of interest. However, K_d values also reflect binding at receptor protein sites other than the modulatory site. We designed derivatives of retinoid X receptor (RXR) antagonist CBTF-EE (I) with modifications that altered their conformational flexibility. Compounds 6a,b and 7a,b showed quite similar K_d values, but 7a,b exhibited 10-fold higher K_i values than those of 6a,b. Further, 6a,b showed potent RXR-antagonistic activity, while 7a,b were inactive. These results suggest that increased conformational flexibility promotes binding at nontarget receptor sites. In this situation, conventional determination of K_d is less effective for screening purposes than the determination of K_i using a ligand that binds specifically to the site regulating transcriptional activity. Thus, the use of K_i values for orthosteric ligands may increase the hit rate in screening active regulatory mols.

ACS Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C19H18O2, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gillespie, James E. published the artcileRegioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines, HPLC of Formula: 638-45-9, the publication is Journal of the American Chemical Society (2021), 143(25), 9355-9360, database is CAplus and MEDLINE.

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the arene ortho position. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly to ortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsym., selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuable ortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rodriguez-Muniz, Gemma M. published the artcileModulation by Phosphonium Ions of the Activity of Mitotropic Agents Based on the Chemiluminescence of Luminols, HPLC of Formula: 638-45-9, the publication is Molecules (2022), 27(4), 1245, database is CAplus and MEDLINE.

Mitochondria-targeting drugs and diagnostics are used in the monitoring and treatment of mitochondrial pathologies. In this respect, a great number of functional compounds have been made mitotropic by covalently attaching the active moiety onto a triphenylphosphonium (TPP) cation. In this regard, luminol (probably the most widely known chemiluminescent mol.) has been employed for a number of biol. applications, including ROS detection. Hence, the photophys. interaction between the light-emitting species 3AP * and TPP cations needs to be evaluated, as it can add valuable information on the design of novel emission-based mitotropic systems. Author’s herein investigate the quenching effect of ethyltriphenylphosphonium cation onto substituted 3-aminophthalates. These were prepared in situ upon hydrolysis of the corresponding anhydrides, which were synthesized from 3-aminophthalimides. Steady-state fluorescence and time-resolved experiments were employed for the evaluation of a possible electron transfer quenching by phosphonium ions. A minor contribution of static quenching that was also detected is attributed to complex formation in the ground state. Accordingly, the chemiluminescence of luminol was indeed strongly reduced in the presence of phosphonium ions. Author’s results have to be taken into account during the design of new chemiluminescent mitotropic drugs or diagnostic agents of the luminol family.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Wei published the artcileEnhancing Transition Dipole Moments of Heterocyclic Semiconductors via Rational Nitrogen-Substitution for Sensitive Near Infrared Detection, Formula: C6H13I, the publication is Advanced Materials (Weinheim, Germany) (2022), 34(28), 2201600, database is CAplus and MEDLINE.

Designing ultrastrong near-IR (NIR) absorbing organic semiconductors is a critical prerequisite for sensitive NIR thin film organic photodetectors (OPDs), especially in the region of beyond 900 nm, where the absorption coefficient of com. single crystalline silicon (c-Si) is below 10³ cm^-1. Herein, a pyrrolo[3,2-b]thieno[2,3-d]pyrrole heterocyclic core (named as BPPT) with strong electron-donating property and stretched geometry is developed. Relative to their analog Y6, BPPT-contained mols., BPPT-4F and BPPT-4Cl, show substantially upshifted and more delocalized highest occupied MOs, and larger transition dipole moments, leading to bathochromic and hyperchromic absorption spectra extending beyond 1000 nm with very large absorption coefficients (up to 3.7-4.3 x 10⁵ cm^-1) as thin films. These values are much higher than those (10⁴ to 1 x 10⁵ cm^-1) of typical organic semiconductors, and 1-2 orders higher than those of com. inorganic materials, such as c-Si, Ge, and InGaAs. The OPDs based on BPPT-4F or BPPT-4Cl blending polymer PBDB-T show high detectivity of above 10¹² Jones in a wide wavelength range of 310-1010 nm with excellent peak values of 1.3-2.2 x 10¹³ Jones, resp., which are comparable with and even better than those com. inorganic photodetectors.

Advanced Materials (Weinheim, Germany) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H14BrNO5S2, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Fei published the artcileTransition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles with sodium trifluoromethanesulfinate in ionic liquids, Recommanded Product: 1-Iodohexane, the publication is Tetrahedron Letters (2021), 153015, database is CAplus.

An acid-promoted protocol has been developed to achieve the transition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles I (R = H, 4-Me, 5-benzyloxy, 6-F, etc.; R¹ = H, Me, Et; R² = H, Ph) using sodium trifluoromethanesulfinate in an imidazolium-based ionic liquid ([Hmim]Br) to obtain subtd. ((trifluoromethyl)thio)-1H-indole derivatives II. The [Hmim]Br not only acts as a recyclable solvent, but also as the reductant in this transformation. The advantages of this chem. include simple operation, use of a recyclable solvent, avoidance of transition-metal and phosphorus, and gram-scale synthesis.

Tetrahedron Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C9H9F5Si, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Radwan, Ahmed S. published the artcileSynthesis, characterization, and self-assembly of fluorescent fluorine-containing liquid crystals, COA of Formula: C6H13I, the publication is Luminescence (2021), 36(7), 1751-1760, database is CAplus and MEDLINE.

In the current work, the synthesis, self-assembly, and mesogenic properties of new perfluorinated para-terphenyls bearing various para-substituted alkoxy and thioalkoxy chains was described. The terphenyl core was prepared using Cu(I) (or Cu(I)/phenanthroline)-catalyzed decarboxylative carbon-carbon (or carbon-oxygen [sulfur]) cross-coupling from the analogous aromatic iodide and fluorobenzoate potassium salt. The mol. structures of the prepared perfluorinated terphenyls were demonstrated with ¹H, ¹³C, and ¹⁹F NMR, as well as FT-IR and X-ray crystallog. The liquid crystalline properties and mesogenic phases were characterized with differential scanning calorimetry and high-resolution polarized optical microscope. Both UV-visible absorbance and emission spectra demonstrated solvatochromism. Supramol. self-assembly of the generated perfluorinated para-terphenyls was monitored by van der Waals and π-π stacking interaction forces. The creation of nanofibrous architectures was monitored by SEM.

Luminescence published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Fei published the artcileTransition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles with sodium trifluoromethanesulfinate in ionic liquids, Recommanded Product: 1-Iodohexane, the publication is Tetrahedron Letters (2021), 153015, database is CAplus.

An acid-promoted protocol has been developed to achieve the transition-metal- and phosphorus-free electrophilic trifluoromethylthiolation of indoles I (R = H, 4-Me, 5-benzyloxy, 6-F, etc.; R¹ = H, Me, Et; R² = H, Ph) using sodium trifluoromethanesulfinate in an imidazolium-based ionic liquid ([Hmim]Br) to obtain subtd. ((trifluoromethyl)thio)-1H-indole derivatives II. The [Hmim]Br not only acts as a recyclable solvent, but also as the reductant in this transformation. The advantages of this chem. include simple operation, use of a recyclable solvent, avoidance of transition-metal and phosphorus, and gram-scale synthesis.

Tetrahedron Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C9H9F5Si, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Jia-Wang published the artcileNickel-Catalyzed Switchable Site-Selective Alkene Hydroalkylation by Temperature Regulation, Product Details of C6H13I, the publication is Angewandte Chemie, International Edition (2022), 61(31), e202205537, database is CAplus and MEDLINE.

A nickel-catalyzed switchable site-selective alkene hydroalkylation was reported. The selection of reaction temperatures led to protocols that provide regiodivergent hydroalkylated products starting from a single alkene substrate. This protocol allowed the convenient synthesis of α- and β-branched protected amines, both of which are important to the fields of pharmaceutical chem. and biochem. In addition, enantioenriched β-branched alkylamines can be accessed in a catalytic asym. variant. Preliminary mechanistic studies indicate that the formation of a more stable nickelacycle provides the driving force of migration. The thermodn. and kinetic properties of different reduction elimination intermediates are responsible for the switchable site-selectivity.

Angewandte Chemie, International Edition published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C13H9FO2, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com