Category: 638-45-9

Dai, Shengfei published the artcileMetal-free and Selectfluor-mediated diverse transformations of 2-alkylthiobenzamides to access 2,3-dihydrobenzothiazin-4-ones, benzoisothiazol-3-ones and 2-alkylthiobenzonitriles, Recommanded Product: 1-Iodohexane, the publication is Organic Chemistry Frontiers (2022), 9(15), 4016-4022, database is CAplus.

Diverse transformations of 2-alkylthiobenzamides were established to synthesize 2,3-dihydrobenzothiazin-4-ones, benzoisothiazol-3-ones and 2-alkylthiobenzonitriles in the presence of Selectfluor. Both NaI-HI and TFA-Ac₂O systems control the selective C-S bond cleavage and C-H bond functionalization to access 2,3-dihydrobenzothiazin-4-ones and 2-substituted 2,3-dihydrobenzothiazin-4-ones, resp. Notably, this was the first example of using Selectfluor as a methylene source to construct important 2,3-dihydrobenzothiazin-4-ones. In the presence of HCl, benzoisothiazol-3-ones were obtained in good yields. Furthermore, 2-alkylthiobenzonitriles could also be prepared using the same NaI-HI system via a thioether-directed and Selectfluor-mediated dehydration of 2-alkylthiobenzamides.

Organic Chemistry Frontiers published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Hong-Liang published the artcilePalladium-Catalyzed Enantioselective C(sp³)-H Arylation of 2-Propyl Azaaryls Enabled by an Amino Acid Ligand, Product Details of C6H13I, the publication is Organic Letters (2022), 24(6), 1286-1291, database is CAplus and MEDLINE.

A palladium(II)-catalyzed enantioselective arylation of unbiased secondary C(sp3)-H bonds was developed. The enantioselectivity was controlled by the combination of a pyridyl or isoquinolinyl directing group and an amino acid, N-Boc-2-pentyl proline. A variety of 2-Pr azaaryls and biaryl iodides were employed to provide arylated products in moderate to good yields (up to 82%) with high enantioselectivities (up to 93:7 er). This reaction is a rare example of an amino-acid-enabled enantioselective acyclic methylene C(sp3)-H arylation. Furthermore, the reaction proceeded with high enantioselectivity even on a gram scale, and the product was transformed to a 5,6,7,8-tetrahydroisoquinoline bioactive mol. Kinetic isotope effect (KIE) experiments indicated that C-H activation is the rate-determining step for the enantioselective C(sp3)-H arylation.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tian, Chengze published the artcileDiscovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity, Quality Control of 638-45-9, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128271, database is CAplus and MEDLINE.

Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymic and cellular activities. Most compounds displayed nanomolar inhibitory activities against PI3Ks, among which 25 displayed high LLE and micromolar inhibitory potency against three human tumor cell lines (IC₅₀ = 0.264μM, 2.04μM, 1.14μM).

Bioorganic & Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C18H34N4O5S, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Yuqing published the artcileSynthesis of Homoallylic Amines by Radical Allylation of Imines with Butadiene under Photoredox Catalysis, HPLC of Formula: 638-45-9, the publication is Angewandte Chemie, International Edition (2022), 61(29), e202204516, database is CAplus and MEDLINE.

A conceptually different radical-radical cross-coupling strategy for the synthesis of a homoallyl amines RCH₂CH=CHCH₂CH(NHR¹)(R²) (R = oxetan-3-yl, 3-methylbut-3-en-1-yl, 2-(tert-butoxy)-2-oxoethyl, etc.; R¹ = 4-fluorophenyl, 2,4,6-trimethylphenyl, naphthalen-2-yl, etc.; R² = thiophen-2-yl, 3,4-dimethoxyphenyl, 4-[methoxy(oxo)methyl]phenyl, etc.) between an α-amino alkyl radical and a transient allylic radical have been reported. This metal-free method provided a novel approach for the synthesis of homoallylic amines (>80 examples) from readily available materials with excellent regioselectivity and exceptional broad functional group compatibility.

Angewandte Chemie, International Edition published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shinohara, Mai published the artcilePhoto-control of Cellular Uptake by the Selective Adsorption of Spiropyran Derivatives on Albumin, HPLC of Formula: 638-45-9, the publication is Chemistry Letters (2022), 51(6), 594-597, database is CAplus.

A photochromic spiropyran derivative (SP6) as a drug tag was prepared SP6 was selectively taken up into cells by photo-controlling the adsorption on albumin, which has attracted attention as a carrier for delivering drugs to tumor cells. The desorption of SP6 from albumin was achieved via the isomerization and hydrolysis of SP6.

Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C3H6BrNaO3S, HPLC of Formula: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kuai, Chang-Sheng published the artcilePalladium-Catalyzed Regio- and Stereoselective Hydroaminocarbonylation of Unsymmetrical Internal Alkynes toward α,β-Unsaturated Amides, COA of Formula: C6H13I, the publication is Organic Letters (2022), 24(24), 4464-4469, database is CAplus and MEDLINE.

α,β-Unsaturated amides play a vital role in natural products, pharmaceuticals, organic synthesis, and functional materials. Herein, authors disclosed a regio- and stereoselective hydroaminocarbonylation of unsym. internal alkynes via palladium catalysis to synthesize α,β-unsaturated amides. This protocol features excellent regio- and exclusive (E)-stereoselectivity, high atom and step-economy, broad substrate scope, and functional group tolerance.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, COA of Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cheng, Chaozhihui published the artcileNickel-Catalyzed Arylcarbamoylation of Alkenes of N-(o-Iodoaryl)acrylamides with Nitroarenes via Reductive Aminocarbonylation: Facile Synthesis of Carbamoyl-Substituted Oxindoles, Name: 1-Iodohexane, the publication is Organic Letters (2021), 23(24), 9543-9547, database is CAplus and MEDLINE.

Nickel-catalyzed arylcarbamoylation reactions of alkenes of N-(o-haloaryl)acrylamides with CO and nitroarenes via reductive aminocarbonylation to produce carbamoyl-substituted oxindoles with an all-carbon quaternary stereogenic center are presented. Starting with N-(o-haloaryl)acrylamides, simple CO, and inexpensive nitroarenes and using a Ni catalyst, a dinitrogen-based ligand, a Zn reductant, a TMSCl additive, and a base system, this protocol enables the synthesis of various carbamoyl-substituted oxindoles and allows the efficient late-stage derivatization of valuable mols.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Fu-Peng published the artcileCopper-Catalyzed Borylative Methylation of Alkyl Iodides with CO as the C1 Source: Advantaged by Faster Reaction of CuH over CuBpin, Application In Synthesis of 638-45-9, the publication is Angewandte Chemie, International Edition (2021), 60(21), 11730-11734, database is CAplus and MEDLINE.

CuH and CuBpin are versatile catalysts and intermediates in organic chem. However, studies that involve both CuH and CuBpin in the same reaction is still rarely reported due to their high reactivity. Now, a study on CuH- and CuBpin-catalyzed borylative methylation of alkyl iodides with CO as the C1 source is reported. Various one carbon prolongated alkyl boranes (RCH₂Bpin and RCH(Bpin)₂) were produced in moderate to good yields from the corresponding alkyl iodides (RI). In this cooperative system, CuH reacts with alkyl iodide faster than CuBpin.

Angewandte Chemie, International Edition published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C7H5Cl2NO, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Geng, Hui-Qing published the artcileCopper-Catalyzed Alkoxycarbonylation of Alkyl Iodides for the Synthesis of Aliphatic Esters: Hydrogen Makes the Difference, Name: 1-Iodohexane, the publication is Organic Letters (2021), 23(20), 8062-8066, database is CAplus and MEDLINE.

A copper-catalyzed alkoxycarbonylation transformation of unactivated alkyl iodides was developed. Various alkyl iodides were converted into the corresponding tert-Bu esters in good yields. NaOt-Bu acts as both a nucleophile and a base. Moreover, other types of aliphatic esters was also be obtained in moderated yields if extra alcs. are added. Both primary and secondary alkyl alcs. can react successfully.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Name: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Guo, Yongxian published the artcileForce-Induced Molecular Isomerization for the Construction of Multicolor Luminescent Segmented Molecular Crystals, Related Products of iodides-buliding-blocks, the publication is Advanced Optical Materials (2022), 10(2), 2101794, database is CAplus.

Multicolor luminescent segmented materials have attracted tremendous research interest due to their potential applications as barcoding materials in information security and anti-counterfeiting. Although much effort has been devoted to the preparation of photonic barcodes based on different light-emitting materials, the rational design of barcoding materials with well-controlled emission color and length at desired position remains a challenge. Here, a novel strategy to fabricate multicolor luminescent segmented 1D mol. crystals is reported by manipulating the mol. conformation and intermol. interactions of the mechanochromic crystals, which are assembled from a rationally designed twisting conjugated mol. The emission color of these mechanochromic crystals changes from green to orange with the mechanism of synergy effect of force-induced mol. isomerization from trans to cis state and mol. packing changes from cross to parallel, which is revealed by single crystal X-ray diffraction. Multicolor luminescent segmented 1D microribbons are fabricated by applying precisely controlled forces by tapping mode at. force microscope, which shows the encoding capability. These findings provide a new method that allows the controllable fabrication of segmented materials with tunable emission color and length at desired position toward barcoding applications.

Advanced Optical Materials published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com